You Searched For: Antibodies

Catalog Number: (CA76634-844)

Supplier: Diagnostic Biosystems

Description: Ki-67 is a nuclear protein, which is expressed in proliferating cells. Ki-67 is preferentially expressed during late G1-, S-, M-, and G2-phases of the cell cycle, while cells in the G0 (quiescent) phase are negative for this protein.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 145 kDa protein. CD117/c-kit is a transmembrane receptor tyrosine kinase and is expressed in many tissues and cells. CD117/c-kit is involved in the development of several lineages of stem cells, such as germ cells, neural crest derived melanocytes and hematopoietic precursor cells. This antibody can be used in the identification of gastrointestinal stromal tumors.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 180 kDa protein, known as Flk-1, KDR or vascular endothelial growth factor receptor 2 (VEGFR2). Flk-1 is a cell membrane receptor kinase. Flk-1 is a high affinity receptor for vascular endothelial growth factor and is putatively involved in the growth of endothelial cells and angiogenesis.

Supplier: Diagnostic Biosystems

Description: Uroplakins (UPs) are a family of transmembrane proteins (UPs Ia, Ib, II and III) that are specific differentiation products of urothelial cells. Uroplakins are markers of terminally differentiated urothelium. Uroplakin II (UPII) is a newly described sensitive marker for urothelial carcinoma (UC). The expression profile of UPII in different types of UC and its utility in the diagnostic setting are needed.

Catalog Number: (CA76634-672)

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 180 kDa protein, known as Flk-1, KDR or vascular endothelial growth factor receptor 2 (VEGFR2). Flk-1 is a cell membrane receptor kinase. Flk-1 is a high affinity receptor for vascular endothelial growth factor and is putatively involved in the growth of endothelial cells and angiogenesis.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 65 kDa protein known as CDC25A. The activity of cyclin-dependent kinases in cell cycle is regulated by the phosphorylation status, which is controlled by the antagonistic action of wee 1 kinase and Cdc25 phosphatases. Three CDC25 genes are present in human cells: CDC25A, CDC25B and CDC25C. CDC25A and CDC25B are expressed throughout the cell cycle, with peak expression in G1 for CDC25A and in both G1-S phase and G2 for CDC25B. CDC25C is mainly expressed in G2 phase.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 33-36 kDa protein known as ERCC1 (excision repair cross complementing) polypeptide. ERCC1 is required for nucleotide excision repair of damaged DNA and is homologous to RAD10. In mammalian cells, XPG cleaves 3’ of the DNA lesion while ERCC1-XPF complex makes the 5’ incision.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 32 to 34 kDa protein known as replication protein A (RPA). RPA is involved in DNA replication, repair, and recombination. Human RPA is a stable heterotrimer of 70 kDa, 32-34 kDa and 11 to 14 kDa subunits (RPA70, RPA32 and RPA14 respectively). RPA is required for the SV40 large tumor antigen-catalyzed unwinding for SV40 DNA and stimulates DNA polymerase α and δ.

Supplier: Diagnostic Biosystems

Description: This antibody is specific against an epitope located on the β chain (i.e., in S-100a and S-100b) but not on the α- chain of S-100 (i.e., in S-100a and S-100ao). This antibody can be used to localize S-100a and S-100b in various tissue sections.

Catalog Number: (CA76634-666)

Supplier: Diagnostic Biosystems

Description: Phosphohistone H3 (PHH3) is a core histone protein, which together with other histones, forms the major protein constituents of the chromatin in eukaryotic cells. In mammalian cells, phosphohistone H3 is negligible during interphase but reaches a maximum for chromatin condensation during mitosis.Immunohistochemical studies showed anti-PHH3 specifically detected the core protein histone H3 only when phosphorylated at serine 10 or serine 28. Studies have also revealed no phosphorylation on the histone H3 during apoptosis.PHH3 can serve as a mitotic marker to separate mitotic figures from apoptotic bodies and karyorrhectic debris, which may be a very useful tool in diagnosis of tumor grades, especially in CNS, skin, gyn., soft tissue, and GIST.

Supplier: Diagnostic Biosystems

Description: Chromogranin A is a 439 amino acid protein present in secretory granules of a wide variety of endocrine cells and neurons. A positive staining is seen in the secretory granules of parathyroid, adrenal medulla, anterior pituitary gland and Langerhans islets of pancreas. This antibody stains a variety of neuroendocrine tumors.

Catalog Number: (CA76634-640)

Supplier: Diagnostic Biosystems

Description: This antibody reacts with cytokeratins of 58, 56, 52, 60, 51, 48 and 68 kDa MW. This antibody is well suited for the staining of a broad spectrum of human keratins.

Catalog Number: (CA76634-636)

Supplier: Diagnostic Biosystems

Description: This antibody reacts with hCG. It stains strongly with the human placenta and placental trophoblasts.

Supplier: Diagnostic Biosystems

Description: p63 is a homolog of the tumor suppressor p53, it is identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63, vital for the development of the prostate and selectively expressed by normal prostate basal cells, has been shown to be a promising complementary basal cell specific marker to High Molecular Weight-Cytokeratin (HMW-CK), for the differential diagnosis of benign prostatic lesions and prostatic carcinoma. p63 has also been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC), with a sensitivity of ~90% . Specificity for lung SqCC, vs. lung adenocarcinoma (LADC), is approximately 80. In breast tissue, p63 has been identified in myoepithelial cells of normal ducts.

Supplier: Diagnostic Biosystems

Description: CD4 is glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. It is a co-receptor that assists the T-cell receptor (TCR) with antigen-presenting cell and also interacts directly with MHC class II molecules of the surface of antigen presenting cells. Most mature T-cell lymphomas are CD4 positive with the exception of aggressive NK-cell leukemia and extranodal NL/T-cell lymphoma. CD4 plays an important role in the classification of lymphocytes in inflammatory legions and malignant lymphomas.

Catalog Number: (CA76634-280)

Supplier: Diagnostic Biosystems

Description: This antibody recognizes a protein of 25 to 26kDa, identified as bcl-2 β-oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 alpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. This antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and small number in which neoplastic cells are bcl-2 negative.