You Searched For: Diagnostic Biosystems

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 65 kDa protein known as CDC25A. The activity of cyclin-dependent kinases in cell cycle is regulated by the phosphorylation status, which is controlled by the antagonistic action of wee 1 kinase and Cdc25 phosphatases. Three CDC25 genes are present in human cells: CDC25A, CDC25B and CDC25C. CDC25A and CDC25B are expressed throughout the cell cycle, with peak expression in G1 for CDC25A and in both G1-S phase and G2 for CDC25B. CDC25C is mainly expressed in G2 phase.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 33-36 kDa protein known as ERCC1 (excision repair cross complementing) polypeptide. ERCC1 is required for nucleotide excision repair of damaged DNA and is homologous to RAD10. In mammalian cells, XPG cleaves 3’ of the DNA lesion while ERCC1-XPF complex makes the 5’ incision.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 32 to 34 kDa protein known as replication protein A (RPA). RPA is involved in DNA replication, repair, and recombination. Human RPA is a stable heterotrimer of 70 kDa, 32-34 kDa and 11 to 14 kDa subunits (RPA70, RPA32 and RPA14 respectively). RPA is required for the SV40 large tumor antigen-catalyzed unwinding for SV40 DNA and stimulates DNA polymerase α and δ.

Supplier: Diagnostic Biosystems

Description: This antibody is specific against an epitope located on the β chain (i.e., in S-100a and S-100b) but not on the α- chain of S-100 (i.e., in S-100a and S-100ao). This antibody can be used to localize S-100a and S-100b in various tissue sections.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 49 kDa protein. At least five CD1 genes are identified (CD1a, b, c, d, and e). This antibody reacts with cortical thymocytes, Langerhans cells in epidermis, dendritic cells of dermis and Langerhans cells of mucosa of tonsil. This antibody may be useful in the characterization of leukemias and lymphomas.

Supplier: Diagnostic Biosystems

Description: SOX10 is widely expressed in normal human tissues including melanocytes and breast tissue. SOX10 is also an important marker in malignant tumors such as melanoma, breast carcinoma, gliomas, and benign tumors such as schwannomas.SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.

Catalog Number: (CA76634-506)

Supplier: Diagnostic Biosystems

Description: This antibody stains with ORF-73 of human herpesvirus 8 (HHV8). HHV8 is the likely etiological agent of Kaposi sarcoma (KS). HHV8 encodes a latent nuclear antigen (LNA), which is the product of the viral gene ORF 73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product, which may be related to its oncogenic activity.

Catalog Number: (CA76634-368)

Supplier: Diagnostic Biosystems

Description: This antibody is specific to a 45 kDa protein, which is identified as MyoD1. This antibody is specific to an epitope of amino acid 3-56 in the N-terminus of mouse MyoD1. This antibody does not react with myogenin, Myf5 or Myf6. MyoD1 stains the nuclei of myoblasts in developing muscle tissues. MyoD1 is not detected in normal adult tissue but is expressed strongly in the tumor cell nuclei of rhabdomyosarcomas.

Catalog Number: (CA76634-420)

Supplier: Diagnostic Biosystems

Description: This antibody is specific to 34 kDa protein known as myogenin. Myogenin is a member of family of myogenic regulatory genes which includes MyoD, MyF5 and MRF4. These genes encode a set of transcription factors which are essential for muscle development. Expression of myogenin is restricted to cells of skeletal muscle origin.

Catalog Number: (CA76634-298)

Supplier: Diagnostic Biosystems

Description: Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pH <5.7) and basic (pH >6.0) subfamilies. The acidic keratins have molecular weights (MW) of 56.5, 55, 51, 50, 50', 48, 46, 45, and 40kDa. MAb AE3 recognizes the 65-67, 64, 59, 58, 56, and 52kDa keratins of basic subfamily. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE1/AE3 is a broad-spectrum anti pan-keratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g., squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer.

Catalog Number: (CA76634-370)

Supplier: Diagnostic Biosystems

Description: This antibody reacts with CD21 antigen of MW 145 kDa, present on the surface of mature B cells. The antigen is present at high density on follicular dendritic cells. CD21 is involved in transmitting growth-promoting signals to the interior of the B cell.

Catalog Number: (CA76634-844)

Supplier: Diagnostic Biosystems

Description: Ki-67 is a nuclear protein, which is expressed in proliferating cells. Ki-67 is preferentially expressed during late G1-, S-, M-, and G2-phases of the cell cycle, while cells in the G0 (quiescent) phase are negative for this protein.

Catalog Number: (CA76634-640)

Supplier: Diagnostic Biosystems

Description: This antibody reacts with cytokeratins of 58, 56, 52, 60, 51, 48 and 68 kDa MW. This antibody is well suited for the staining of a broad spectrum of human keratins.

Catalog Number: (CA76634-636)

Supplier: Diagnostic Biosystems

Description: This antibody reacts with hCG. It stains strongly with the human placenta and placental trophoblasts.

Supplier: Diagnostic Biosystems

Description: p63 is a homolog of the tumor suppressor p53, it is identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63, vital for the development of the prostate and selectively expressed by normal prostate basal cells, has been shown to be a promising complementary basal cell specific marker to High Molecular Weight-Cytokeratin (HMW-CK), for the differential diagnosis of benign prostatic lesions and prostatic carcinoma. p63 has also been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC), with a sensitivity of ~90% . Specificity for lung SqCC, vs. lung adenocarcinoma (LADC), is approximately 80. In breast tissue, p63 has been identified in myoepithelial cells of normal ducts.

Supplier: Diagnostic Biosystems

Description: CD4 is glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. It is a co-receptor that assists the T-cell receptor (TCR) with antigen-presenting cell and also interacts directly with MHC class II molecules of the surface of antigen presenting cells. Most mature T-cell lymphomas are CD4 positive with the exception of aggressive NK-cell leukemia and extranodal NL/T-cell lymphoma. CD4 plays an important role in the classification of lymphocytes in inflammatory legions and malignant lymphomas.