You Searched For: Diagnostic Biosystems

Catalog Number: (CA76634-326)

Supplier: Diagnostic Biosystems

Description: This antibody is specific to human cytokeratins 8 (52.5 kDa) and 18 (45 kDa). This antibody stains simple and glandular epithelium. This antibody can be useful for the identification of adenocarcinomas and most squamous cell carcinomas.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 70 kD protein known as Ku (p70).The Ku protein is localized in the nucleus and is composed of subunits referred to as Ku-70 (or p70) and Ku-86 or (p86). Both subunits of the Ku protein have been cloned, and a number of functions have been proposed for Ku, including cell signaling, DNA replication and transcriptional activation. Ku is involved in Pol II-directed transcription by virtue of its DNA binding activity, serving as the regulatory component of the DNA-associated protein kinase that phosphorylates Pol II and transcription factor Sp.

Catalog Number: (CA76634-400)

Supplier: Diagnostic Biosystems

Description: This antibody recognizes a doublet of 50 kDa and a single band of 42 kDa identified as cyclin E. Cyclin proteins are a family of related proteins, which control the progression of the eukaryotic cell cycle. Overexpression of cyclin E shortens the length of the G1 phase, accelerating progression of S phase. The activity of cyclin E is mediated through its activation of cyclin dependent kinase 2 (cdk2) protein and is modulated by the presence of tumor suppressor proteins such as p16.

Supplier: Diagnostic Biosystems

Description: CD138, also known as Syndecan-1, is a member of the transmembrane heparan sulfate proteoglycan family, acts as an extracellular matrix receptor and is involved in many cellular functions, including cell-cell adhesion and cell-matrix adhesion. CD138 expression is found in both hematopoietic and non-hematopoietic cells. In the hematopoietic system, CD138 labels plasma cells. It is an excellent marker for plasmacytic differentiation within the spectrum of hematologic malignancy. Among non-hematolymphoid cells, CD138 reactivity is observed in many types of epithelial cells and stoma cells in both normal and tumor tissues.

Supplier: Diagnostic Biosystems

Description: This antibody does not show any cross-reactivity with kappa light chain. It stains B cell follicles in human lymphoid tissues. The mantle zone shows a mosaic pattern of labeling while the germinal centers show a coarse meshwork pattern of staining.

Catalog Number: (CA76634-526)

Supplier: Diagnostic Biosystems

Description: This antibody is specific to epithelial membrane antigen (EMA), CA 15-3, or polymorphic epithelial mucin. This antibody stains an underglycosylated MUC1 often present on carcinoma cells.

Catalog Number: (CA76634-342)

Supplier: Diagnostic Biosystems

Description: This antibody reacts specifically with a 32 kDa protein similar to the CD8 molecule. This antibody stains cytotoxic/suppressor T cells and shows staining patterns similar to clustered CD8 monoclonal antibodies.

Catalog Number: (CA76634-314)

Supplier: Diagnostic Biosystems

Description: Alpha fetoprotein (AFP) is a single chain glycoprotein of 70 kDa that is normally expressed in the fetal liver, gastrointestinal tract and yolk sac. This antibody recognizes an epitope of α-fetoprotein present in human and several other species.

Supplier: Diagnostic Biosystems

Description: This antibody is specific to a Sialoglycoprotein of 27 to 32 kDa known as CD99 or MIC2 gene product. CD99 is expressed on the cell membrane of some lymphocytes, cortical thymocytes and granulosa cells of the ovary, Sertoli cells of testis, pancreatic islet cells and some endothelial cells. Mature granulocytes express very little or no CD99.

Catalog Number: (CA76634-514)

Supplier: Diagnostic Biosystems

Description: Recognizes a protein of 48 kDa, which is identified as Adipophilin. It belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases.

Catalog Number: (CA76634-440)

Supplier: Diagnostic Biosystems

Description: This antibody recognizes a 200 kDa glycoprotein (gp200) localized in the brush border of the proximal renal tubules and the luminal surface of Bowman’s capsule. gp200 was expressed by 93% of primary and 84% of metastatic renal carcinomas. Gp200 glycoprotein is also localized in the breast lobules and ducts, parathyroid glands, and epididymis.

Supplier: Diagnostic Biosystems

Description: This antibody is specific to human cytokeratin 18 of 45 kDa. Cytokeratin 18 belongs to a family of acidic type A keratins and exists along with cytokeratin 8 in most simple ductal and glandular epithelia. This antibody does not react with squamous epithelium. It reacts with benign and malignant epithelial lesions as well as a majority of adenocarcinomas and basal cell carcinomas.

Supplier: Diagnostic Biosystems

Description: The antibody is specific against gastrin-containing cells. This anti-body reacts with human gastrin I and human gastrin I fragments. No cross-reactivity was observed with rat gastrin, human big gastrin, human gastrin releasing peptide, sulfated cholecystokinin amide, non-sulfated cholecystokinin amide and cholecystokinin.

Catalog Number: (CA76634-278)

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 180 to 185kDa protein, identified as isoform of leukocyte common antigen (CD45RO) (4th Leucocyte Typing Workshop: Code No. N31). The epitope recognized by this antibody is sensitive to neuraminidase digestion.

Catalog Number: (CA76634-522)

Supplier: Diagnostic Biosystems

Description: MOC-31 antibody recognizes an epithelial-associated, glycoprotein located on the cell membrane surface and in the cytoplasm of virtually all epithelial cells. It is not present in most squamous epithelia, hepatocytes, renal proximal tubular cells, gastric parietal cells and myoepithelial cells. MOC-31 may be used in a panel of antibodies as a negative marker for mesothelioma, or lung adenocarcinoma. Studies have shown that MOC31 is useful in differentiating tumors of unknown origin in liver cancers and distinguishing cholangiocarcinoma from hepatocellular carcinomas

Supplier: Diagnostic Biosystems

Description: This antibody stains with ORF-73 of human herpesvirus 8 (HHV8). HHV8 is the likely etiological agent of Kaposi sarcoma (KS). HHV8 encodes a latent nuclear antigen (LNA), which is the product of the viral gene ORF 73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product, which may be related to its oncogenic activity.