You Searched For: Diagnostic Biosystems

Catalog Number: (CA76634-272)

Supplier: Diagnostic Biosystems

Description: This antibody reacts with 70 and 200 kDa component of the neurofilament polypeptide subunit. It stains neurons, neuronal processes, and peripheral nerves. This antibody reacts with some neuroblastomas and gangliomas but not with other non-neuronal tumors.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 180 kDa protein, known as Flt-1 or vascular endothelial growth factor receptor 1 (VEGFR1). Flt-1 is a cell membrane receptor kinase. Flk-1 has a high affinity receptor for vascular endothelial growth factor and is putatively involved in the growth of endothelial cells and angiogenesis.

Supplier: Diagnostic Biosystems

Description: Claudin 1-8 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell to cell contact, made up of a network of strands to act as a molecular gasket for preventing the leakage of ions, water etc., between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different claudin composition.

Supplier: Diagnostic Biosystems

Description: Ki-67 is a nuclear protein, which is expressed in proliferating cells. Ki-67 is preferentially expressed during late G1-, S-, M-, and G2-phases of the cell cycle, while cells in the G0 (quiescent) phase are negative for this protein.

Catalog Number: (CA76634-562)

Supplier: Diagnostic Biosystems

Description: This antibody recognizes thyroglobulin in hyperplastic and neoplastic thyroid. Thyroglobulin is a protein of 670 kDa consisting of two identical subunits. Thyroglobulin is synthesized by the follicular epithelial cells of the thyroid.

Supplier: Diagnostic Biosystems

Description: This antibody is specific to human CD10 antigen of 100 kDa, also known as common acute lymphocytic leukemia antigen (CALLA). CD10 antigen has been identified on the surface of early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue.

Supplier: Diagnostic Biosystems

Description: This antibody stains the cytoplasm of antigen-positive liver cells in patients with Type B viral hepatitis. This antibody reacts with the 'a' determinant present on the HBsAg subtypes ayw1, ayw2, ayw3, ayw4, ayr, adw2, adw4 and adr. It does not react with normal tissues.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a neuraminidase sensitive oligosaccharide side chain of a glycoconjugate present in immature melanosomes. It reacts with junctional and blue nevus cells. Non-melanocytic cells are negative.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with wild as well as mutant types of P53 protein. It recognizes an epitope in the N-terminus of P53 protein, known to reside between amino acids 35 to 45. This antibody can be demonstrated in 22 to 76% of the colon, stomach, bladder, breast, lung and testes cancers.

Catalog Number: (CA76634-446)

Supplier: Diagnostic Biosystems

Description: This antibody is specific to a cell surface glycoprotein of 80 to 95 kDa, known as CD44. CD44 is expressed on the surface of lymphocytes, monocytes and granulocytes. This antibody reacts with red cells pretreated with 2-aminoethlyl isothiouronium bromide (AET).

Supplier: Diagnostic Biosystems

Description: Anaplastic large cell lymphoma (ALCL) is usually composed of large pleomorphic cells, which express CD30 antigen and the epithelial membrane antigen (EMA). These tumor cells tend to occur in younger patients and may be associated with cutaneous and extranodal involvement. Large cell lymphoma account for approximately 25% of all non-Hodgkin lymphomas in children and young adults.

Supplier: Diagnostic Biosystems

Description: This antibody is specific to 45-60 kDa proteins identified as tau proteins. This antibody does not cross react with tubulin or other microtubule associated proteins. This antibody recognizes a phosphorylation-independent epitope in amino acids 404 to 441 (human). Tau antibody stains human neurofibrillary tangles, neutrophil threads and neurotic plaques associated with Alzheimer’s disease.

Supplier: Diagnostic Biosystems

Description: Epithelial antigen is a cell surface glycoprotein and is broadly distributed in epithelial cells and displays a highly conserved expression in carcinomas. Epithelial antigen has been shown to play an important role as a tumor cell marker in lymph nodes from patients with esophageal carcinoma. Epithelial antigen can be used to distinguish between basal cell and basosquamous carcinomas and squamous cell carcinoma of the skin.

Catalog Number: (CA76634-450)

Supplier: Diagnostic Biosystems

Description: Monoclonal anti-smooth muscle myosin reacts with myosin heavy chain polypeptides of 200 and 204 kDa. It does not react with skeletal, cardiac, or non-muscle myosin. In immunohistochemistry it stains vascular and visceral smooth muscle cells and cells that have smooth muscle-like characteristics.

Catalog Number: (CA76634-518)

Supplier: Diagnostic Biosystems

Description: This antibody reacts with herpes simplex virus type 2. It is specific for the viral glycoprotein D (gD) protein.

Catalog Number: (CA76634-516)

Supplier: Diagnostic Biosystems

Description: Galectin-3 is a member of the beta-galactoside-binding protein family that plays an important role in cell adhesion, cell matrix interactions, macrophage activation, angiogenesis, metastasis, and apoptosis.

Galectin-3 shows strong diffuse cytoplasmic staining in most cases of papillary thyroid carcinoma (PTC), most poorly differentiated thyroid cancers demonstrate galectin-3 protein expression while it is not expressed in anaplastic thyroid cancers. (1) Upregulated expression of galectin-3 is involved in cancer progression and metastasis, and it is suggested that Galectin-3 may be a valuable tool to support diagnosis of parathyroid carcinoma. (2)

Galectin-3 has also been reported to play important roles in the progression of prostate cancer, and their heterogeneous expressions might be associated with different cancer subtypes. (3)