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Anti-MyoD1 Mouse Monoclonal Antibody [clone: 5.2F]

Supplier: Diagnostic Biosystems
Description: This antibody is specific to a 45 kDa protein, which is identified as MyoD1. This antibody is specific to an epitope of amino acid 3-56 in the N-terminus of mouse MyoD1. This antibody does not react with myogenin, Myf5 or Myf6. MyoD1 stains the nuclei of myoblasts in developing muscle tissues. MyoD1 is not detected in normal adult tissue but is expressed strongly in the tumor cell nuclei of rhabdomyosarcomas.

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Anti-Heat Shock Protein 70 Mouse Monoclonal Antibody [clone: W27]

Supplier: Diagnostic Biosystems
Description: This antibody is specific to constitutive (HSP73) and inducible (HSP72) form of HSP70. HSP70 is found to be associated with steroid receptors, actin, P53, polyoma T antigen, nucleotides and other known proteins. HSP70 has been shown to be involved in protective roles against thermal stress, cytotoxic drugs and other damaging conditions.

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Anti-Villin Mouse Monoclonal Antibody [clone: 1D2C3]

Supplier: Diagnostic Biosystems
Description: Villin is One of the gelsolin family of calcium regulated actin binding proteins. Normally expressed in the brush border of epithelial cells lining the gastrointestinal tract, hepatobiliary tract and renal proximal convoluted tubules. In colorectal carcinoma, villin is highly expressed. In practice, villin can be included in the panel used for metastatic carcinoma to detect colorectal origin.

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Anti-HER2/neu (c-erb-2) Rabbit Polyclonal Antibody

Supplier: Diagnostic Biosystems
Description: This antibody recognizes a c-erbB-2 protein, which is a receptor tyrosine kinase of the c-erbB family. It is closely related in structure to the epidermal growth factor receptor. c-erbB-2 oncoprotein is detectable in a subset of breast and other adenocarcinomas, as well as transitional cell carcinomas. In the case of breast cancer, expression determined by immunohistochemistry has been shown to be associated with poor prognosis.

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Anti-Caldesmon Mouse Monoclonal Antibody [clone: hHCD]

Catalog Number: (CA76634-482)
Supplier: Diagnostic Biosystems
Description: This antibody is specific to high molecular weight (120 to 150 kDa) h-Caldesmon. Caldesmon is involved in smooth muscle and non-muscle contraction. Two closely related variants of human Caldesmon have been identified. The h-Caldesmon variant is predominantly expressed in smooth muscle, whereas l-Caldesmon (71 to 80 kDa) is found in non-muscle tissue and cells.
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Anti-Factor XIIIa Mouse Monoclonal Antibody [clone: AC-1A1]

Supplier: Diagnostic Biosystems
Description: This antibody is specific to 160 kDa protein known as Factor XIII-A. Factor XIII is a β-globulin found in plasma and is composed of two subunits, Factor XIII-A and Factor XIII-B. Factor XIII-A is the catalytic subunit and is a dimer of M.W. 160 kDa. Factor XIII is a dermal dendrocyte marker and v variable reaction with these types of tumors.

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Anti-Villin Mouse Monoclonal Antibody [clone: 1D2C3]

Catalog Number: (CA76634-586)
Supplier: Diagnostic Biosystems
Description: Villin is One of the gelsolin family of calcium regulated actin binding proteins. Normally expressed in the brush border of epithelial cells lining the gastrointestinal tract, hepatobiliary tract and renal proximal convoluted tubules. In colorectal carcinoma, villin is highly expressed. In practice, villin can be included in the panel used for metastatic carcinoma to detect colorectal origin.
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Anti-Hepatocyte Mouse Monoclonal Antibody [clone: OCH1E5]

Supplier: Diagnostic Biosystems
Description: Hepatoblastoma is the most common primary tumor of the liver in children. The use of specific hepatocyte markers and also of α fetoprotein or carcinoembryonic antigen are useful for the identification of normal and malignant fetal hepatocytes. This antibody recognizes an uncharacterized antigen present in both adults and fetal normal hepatocytes to produce a distinct granular cytoplasmic staining. This antibody stains majority of hepatocellular carcinomas.

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Anti-Tag-72 Mouse Monoclonal Antibody [clone: B72.3]

Catalog Number: (CA76634-350)
Supplier: Diagnostic Biosystems
Description: This antibody is specific to an oncofetal antigen of >1000 kDa known as tumor associated glycoprotein (TAG-72) or CA 72-4. This antibody defines the mucin carried sialylated-Tn antigen. This antibody stains the majority of human adenocarcinomas including colorectal, pancreatic, gastric, ovarian, endometrial, mammary and non-small cell lung cancer.
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Anti-Mast Cell Tryptase Mouse Monoclonal Antibody [clone: AA1]

Supplier: Diagnostic Biosystems
Description: This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Mast cells contain a number of preformed chemicals mediators such as histamine, chymase, carboxypeptidase, and proteolytic tryptase. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation.

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Anti-Caspase 3/CPP32 Rabbit Polyclonal Antibody

Catalog Number: (CA76634-674)
Supplier: Diagnostic Biosystems
Description: This antibody reacts with the active form of caspase 3 (17 kD protein). Caspase 3 is a member of the interleukin-1 beta-converting enzyme family and is thought to be associated with the induction of apoptosis. Caspase 3 is synthesized as an inactive 32 kD proenzyme and is processed during apoptosis generating two subunits of 17 kD and 12 kD. Caspase 3 stains the epithelial cells of skin, renal proximal tubules, and collecting ducts.
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Anti-P504S Rabbit Monoclonal Antibody [clone: 13H4]

Supplier: Diagnostic Biosystems
Description: P504S has been recently described as a prostate cancer-specific gene that encodes a protein involved in the β-oxidation of branched chain fatty acids. Expression of p504S protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. P504S can be used as a positive marker for PIN.

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Anti-Calponin Mouse Monoclonal Antibody [clone: CALP]

Catalog Number: (CA76634-480)
Supplier: Diagnostic Biosystems
Description: This antibody reacts with a 34 kDa protein known as calponin. Calponin, a calmodulin, binds tropomyosin and F-actin and is thought to be involved in the regulation of smooth muscle contraction. Expression of calponin is restricted to smooth muscle cells. Two isoforms of calponin exist whose molecular weights are 34 KDa and 29 kDa. 29 kDa isoform is primarily restricted to the muscle of the urogenital tract.
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Anti-PTEN Mouse Monoclonal Antibody [clone: 6H2.1]

Supplier: Diagnostic Biosystems
Description: PTEN gene is a tumor suppressor gene that maps to chromosome 10q23. PTEN, a novel tumor suppressor, functions as a regulator of both cell cycle progression and apoptosis ). Potentially, mutation and deletion of PTEN gene may result in a new signal transduction pathway related to human malignant tumors. Studies have demonstrated a reduction of PTEN expression in advanced breast cancers.

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Anti-Uroplakin II (UPK2) Rabbit Polyclonal Antibody

Catalog Number: (CA76634-682)
Supplier: Diagnostic Biosystems
Description: Uroplakins (UPs) are a family of transmembrane proteins (UPs Ia, Ib, II and III) that are specific differentiation products of urothelial cells. Uroplakins are markers of terminally differentiated urothelium. Uroplakin II (UPII) is a newly described sensitive marker for urothelial carcinoma (UC). The expression profile of UPII in different types of UC and its utility in the diagnostic setting are needed.
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Anti-ALK p80 Mouse Monoclonal Antibody [clone: 5A4]

Supplier: Diagnostic Biosystems
Description: Anaplastic large cell lymphoma (ALCL) is usually composed of large pleomorphic cells, which express CD30 antigen and the epithelial membrane antigen (EMA). These tumor cells tend to occur in younger patients and may be associated with cutaneous and extranodal involvement. Large cell lymphoma account for approximately 25% of all non-Hodgkin lymphomas in children and young adults.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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