You Searched For: 4-Hydroxy-3-methylbenzoic+acid


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Catalog Number: (10488-056)
Supplier: Bioss
Description: AMPK is a heterotrimeric complex comprising a catalytic a subunit and regulatory b and g subunits. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK is activated by high AMP and low ATP through a mechanism involving allosteric regulation, promotion of phosphorylation by an upstream protein kinase known as AMPK kinase and inhibition of dephosphorylation. Activated AMPK can phosphorylate and regulate in vivo hydroxy-methylglutaryl-CoA reductase and acetyl-CoA carboxylase, which are key regulatory enzymes of sterol synthesis and fatty acid synthesis, respectively. The human AMPKa1 and AMPKa2 genes encode 548 amino acid and 552 amino acid proteins, respectively. Human AMPKb1 encodes a 271 amino acid protein and human AMPKb2 encodes a 272 amino acid protein. The human AMPKg1 gene encodes a 331 amino acid protein. Human AMPKg2 and AMPKg3, which are 569 and 492 amino acid proteins, respectively, contain unique N-terminal domains and may participate directly in the binding of AMP within the AMPK complex.


Catalog Number: (10075-720)
Supplier: Prosci
Description: The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct Glutamate Receptor Subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990;Hollmann and Heinemann, 1994). The GluR2 subunit is widely expressed throughout the nervous system where it is thought to play key roles in synaptic plasticity and learning and memory (Duprat et al., 2003; Seidenman et al., 2003; Chung et al., 2003; Yan et al., 2002).


Catalog Number: (TCM0248-100MG)
Supplier: TCI America
Description: CAS Number: 2541-69-7
MDL Number: MFCD00059500
Molecular Formula: C19H14
Molecular Weight: 242.32
Purity/Analysis Method: >97.0% (GC)
Form: Crystal
Melting point (°C): 140

Catalog Number: (TCM0427-025G)
Supplier: TCI America
Description: CAS Number: 15448-99-4
MDL Number: MFCD00059263
Molecular Formula: C8H7NO3S
Molecular Weight: 197.21
Purity/Analysis Method: >98.0% (GC)
Form: Crystal
Melting point (°C): 131

SDS


Catalog Number: (EM1.15934.0025)
Supplier: MilliporeSigma
Description: Cas Number: 548-24-3, Synonyms: Dibromodinitrofluorescein Sodium, 25G

SDS


Catalog Number: (10092-240)
Supplier: Proteintech
Description: Protein interacting with C kinase 1 (PICK1) was first cloned as a PKC-binding partner through yeast two hybrid system. PICK1 acts as a critical regulator of membrane receptors’ subcellular trafficking to modulate neural processes such as learning and memory, and is widely expressed in brain, testis, heart, lung, liver, kidney and muscle. It probably binds to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence, for instance, PICK1 is a critical mediator of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking in neural synapses. PICK1 expression on D-serine release and glutamate transport in astrocytes suggests a potential implication of PICK1 in the progression of amyotrophic lateral sclerosis (ALS). PICK1 may also participate in breast cancer development through inhibition of TGF-β signaling.


Supplier: TCI America
Description: CAS Number: 3119-93-5
MDL Number: MFCD00044134
Molecular Formula: C10H12INS
Molecular Weight: 305.18
Purity/Analysis Method: >98.0% (HPLC,T)
Form: Crystal
Melting point (°C): 196
Supplier: TCI America
Description: CAS Number: 10531-78-9
Molecular Formula: C8H7NO
Molecular Weight: 133.15
Purity/Analysis Method: >98.0% (GC)
Form: Crystal
Boiling point (°C): 96
Melting point (°C): 45

SDS

Catalog Number: (TCM0557-025G)
Supplier: TCI America
Description: CAS Number: 95-21-6
MDL Number: MFCD00005771
Molecular Formula: C8H7NO
Molecular Weight: 133.15
Purity/Analysis Method: >99.0% (GC)
Form: Clear Liquid
Boiling point (°C): 201
Flash Point (°C): 75
Specific Gravity (20/20): 1.12

Catalog Number: (TCF0142-025G)
Supplier: TCI America
Description: CAS Number: 18472-87-2
MDL Number: MFCD00070627
Molecular Formula: C20H4Br4Cl4O5
Molecular Weight: 829.63
Form: Powder
Color: Red

SDS


Supplier: TCI America
Description: 1,2-Bis(5-methyl-2-benzoxazolyl)ethylene, Purity: >98.0%(HPLC)(N), Cas number: 1041-00-5, Molecular Formula: C18H14N2O2, Molecular Weight: 290.32, Appearance: Very pale yellow - Yellow solid crystal powder, Size: 25G

SDS

Catalog Number: (10352-704)
Supplier: Bioss
Description: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008].


Catalog Number: (76083-294)
Supplier: Bioss
Description: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.


Supplier: TCI America
Description: CAS Number: 21535-97-7
MDL Number: MFCD00205641
Molecular Formula: C9H8O
Molecular Weight: 132.16
Purity/Analysis Method: >98.0% (GC)
Form: Clear Liquid
Boiling point (°C): 197
Specific Gravity (20/20): 1.06
Storage Temperature: 0-10°C
Supplier: TCI America
Description: CAS Number: 5460-09-3
MDL Number: MFCD00036444
Molecular Formula: C10H9NO7S2
Molecular Weight: 341.28
Purity/Analysis Method: >80.0% (N,T)
Form: Crystal
Catalog Number: (TCT1949-5G)
Supplier: TCI America
Description: CAS Number: 372-30-5
MDL Number: MFCD00040842
Molecular Formula: C6H9F3O3
Molecular Weight: 186.13
Purity/Analysis Method: >97.0% (GC)
Form: Crystal
Color: White
Boiling point (°C): 83
Freezing point (°C): 26

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