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Supplier: Peprotech

Description: OX40L, a member of the TNF superfamily of structurally related proteins, exists primarily as a type II membrane-bound, non-covalently linked, homotrimeric protein. It is expressed on antigen-presenting cells (APCs), such as dendritic cells and activated B-cells, as well as on various other cells such as vascular endothelial cells, mast cells, and natural killer cells. OX40L signals specifically through the OX40 receptor, which is expressed predominantly on CD4+ T cells, but also on certain activated CD8+ T cells. OX40/OX40L functions as a costimulatory signal, which is required for a productive interaction between antigen-presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNγ. OX40/OX40L signaling plays an important role in immuno-regulatory communication, enabling the immune system to distinguish between “friend vs. foe” during activation; a mechanism typically termed immuno-tolerance. Recombinant Human sOX40 Ligand is a glycosylated 133 amino acid protein corresponding to the extracellular TNF homologous domain of the full length transmembrane protein. It migrates with an apparent molecular mass of 15.5 – 25.0 kDa on SDS-PAGE. Recombinant Human sOX40 Ligand has a calculated, theoretical molecular weight of 15.4 kDa.

Supplier: Peprotech

Description: Anti-IgG Rabbit Polyclonal Antibody sIL-2 Receptor alpha

Catalog Number: (75999-420)

Supplier: Peprotech

Description: Monoclonal AntibodyProduced in BALB/c-mice immunized with highly pure Recombinant Human G-CSF. Anti­Human G-CSF­specific antibody was purified from cell culture by Protein A affinity chromatography.

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human IL-36γ (IL-1F9). Anti­Human IL-36γ (IL-1F9)­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Description: Anti-IgG Rabbit Polyclonal Antibody (Biotin) Resistin

Supplier: Peprotech

Description: Anti-IgG Rabbit Polyclonal Antibody sCD14

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human NT-3. Anti­Human NT-3­specific antibody was purified by affinity chromatography employing an immobilized Human NT-3 matrix.

Supplier: Peprotech

Description: Anti-IgG Rabbit Polyclonal Antibody p16-INK-4a TAT

Supplier: Peprotech

Description: Anti-IgG Rabbit Polyclonal Antibody LIGHT

Supplier: Peprotech

Description: GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRalpha (alpha1-alpha4) receptors. GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. Using a Parkinson's disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional rat GDNF ligand is a disulfide-linked homodimer consisting of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine-knot configuration. The calculated molecular weight of Recombinant Rat GDNF is 30.0 kDa.

Catalog Number: (10777-668)

Supplier: Peprotech

Description: PeproTech's Human MCP-1 (CCL2) ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant human MCP-1 (CCL2) in a sandwich ELISA format.

Catalog Number: (10771-552)

Supplier: Peprotech

Description: PeproTech's Murine G-CSF ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant murine G-CSF in a sandwich ELISA format.

Catalog Number: (10771-536)

Supplier: Peprotech

Description: PeproTech's Human MIG (CXCL9) ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant human MIG (CXCL9) in a sandwich ELISA format.

Supplier: Peprotech

Description: Wnt-7a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. It is expressed in placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain. Most Wnt proteins can signal though a mechanism called the canonical Wnt pathway, in which Wnt proteins bind to and activate seven-pass transmembrane receptors of the Frizzled family, ultimately leading to the disruption of β-catenin degradation. Intracellular accumulation of β-catenin increases translocation of the protein into the nucleus, where it binds to TCF/LEF transcription factors to induce the expression of numerous genes. Increased Wnt/β-catenin signaling is associated with tumorigenesis in a diverse set of human cancers. However, Wnt-7a/Frizzled-9 signaling has been shown to act as a tumor suppressor in non-small cell lung cancers. Recombinant Human Wnt-7a is a 35.5 kDa glycoprotein containing 318 amino acids. Due to glycosylation, Wnt-7a migrates between 40-55 kDa by SDS-PAGE gel under unreduced conditions.

Catalog Number: (10771-656)

Supplier: Peprotech

Description: PeproTech's Human IL-4 ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant human IL-4 in a sandwich ELISA format.

Catalog Number: (10781-660)

Supplier: Peprotech

Description: PeproTech's Human/Murine/Rat BMP-2 ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant human/murine/rat BMP-2 in a sandwich ELISA format.