You Searched For: Peprotech

Supplier: Peprotech

Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant Human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino acid residues, which comprises the mature EGF-homologous portion of the Betacellulin protein.

Supplier: Peprotech

Description: Human soluble DLL-1 comprises the extracellular signaling domain of DLL-1, a member of the Delta/Serrate/Lag-2 (DSL) family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. It is expressed primarily in the heart, pancreas and epidermis. DLL-1 functions to specifically activate the Notch-1 and Notch-2 receptors. Proteolytic cleavage of DLL-1 produces a secreted extracellular domain, sDLL-1, that interacts with Notch receptors expressed on adjacent cells. Notch signaling plays an essential role in controlling cell fate decisions during prenatal development and postnatal stem cell renewal, and differentiation in many tissues. Human sDLL-1 blocks monocyte differentiation into macrophages, but permits differentiation into dendritic cells. In hematopoietic progenitor cells, hsDLL-1, suppresses differentiation into B-cells, while promoting differentiation into T-cells and NK cell precursors. In cell culture, human sDLL-1 has been shown to promote expansion of hematopoietic progenitor cells and suppress apoptosis by inhibiting differentiation. Overexpression of Notch receptors appears to inhibit differentiation in several mammalian cell lines, and increasing evidence suggests that Notch signaling is frequently downregulated in human malignancies. The human DLL-1 gene consists of a 528 amino acid extracellular domain with one DSL domain, eight EGF-like repeats, a 23 amino acid transmembrane domain, and a 155 amino acid cytoplasmic domain. The calculated molecular weight of Recombinant Human sDLL-1 is 56.3 kDa.

Supplier: Peprotech

Description: Myostatin is a TGF-β family member that acts as an inhibitor of skeletal muscle growth. This muscle-specific cytokine interacts with Activin type I and type II receptors, and suppresses myoblast proliferation by arresting cell-cycle in the G1 phase. Suppression of myostatin activity facilitates muscle formation, and may be useful in reducing and/or preventing adiposity and type-2 diabetes. Myostatin activity can be blocked by the activin-binding protein follistatin, and by the propeptide of myostatin. The amino acid sequence of mature myostatin is extremely conserved across species, and is the same in murine, rat, chicken, turkey, porcine, and human. Myostatin is expressed as the C-terminal part of a precursor polypeptide, which also contains a short N-terminal signal sequence for secretion, and a propeptide of 243 amino acids. After dimerization of this precursor, the covalent bonds between the propeptide and the mature ligand are cleaved by furin-type proteases. However, the resulting two proteins remain associated through non-covalent interactions, and are secreted as a latent complex. Recombinant Human/Murine/Rat Myostatin is a 25.0 kDa protein consisting of two identical 109 amino acid polypeptides linked by a single disulfide bond.

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Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human FGF-17. Anti­Human FGF-17­specific antibody was purified by affinity chromatography employing an immobilized Human FGF-17 matrix.

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human EGF Receptor (EGFR). Anti­Human EGF Receptor (EGFR)­specific antibody was purified by affinity chromatography employing an immobilized Human EGF Receptor (EGFR) matrix.

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human sCD22. Anti­Human sCD22­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human Nanog. Anti­Human Nanog­specific antibody was purified by affinity chromatography and then biotinylated.

Catalog Number: (10777-078)

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human IGF-BP5. Anti­Human IGF-BP5­specific antibody was purified by affinity chromatography employing an immobilized Human IGF-BP5 matrix.

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human IGF-BP1. Anti­Human IGF-BP1­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human Wnt-1. Anti­Human Wnt-1­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human BCA-1 (CXCL13). Anti­Human BCA-1 (CXCL13)­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Description: Produced from sera of goats immunized with highly pure Recombinant Human IL-12. Anti­Human IL-12­specific antibody was purified by affinity chromatography and then biotinylated.

Catalog Number: (10776-384)

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human sTNF Receptor Type I. Anti­Human sTNF Receptor Type I­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Description: Anti-IgG Rabbit Polyclonal Antibody Artemin

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human IL-17B. Anti­Human IL-17B­specific antibody was purified by affinity chromatography employing an immobilized Human IL-17B matrix.

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human IL-17B. Anti­Human IL-17B­specific antibody was purified by affinity chromatography and then biotinylated.