You Searched For: BACHEM AMERICAS INC

Supplier: Bachem Americas

Description: The pyroglutamate-modified amyloid-β peptides derived from Aβ40 (H-7422) and Aβ42 (H-4796) have gained considerable attention as potential key participants in the pathology of Alzheimer's disease (AD) due to their abundance in AD brain, high aggregation propensity, stability, and cellular toxicity. Aβ40 and 42 can be N-terminally truncated by action of cathepsin B. The cyclization of Glu³ is catalyzed by glutaminyl cyclase. Hence, inhibition of these enzymes could be a therapeutic approach to AD.

Catalog Number: (10796-774)

Supplier: Bachem Americas

Description: Effective catalyst for conjugate addition reactions of aldehydes to β-substituted nitroolefins.

Supplier: Bachem Americas

Description: H-Asp(OtBu)-2-chlorotrityl resin (200-400 mesh) (Low Substitution) 1g, Storage Condition: -20 +/- 5 degree C, Substitution < 0. 60 mmol/g.

Supplier: Bachem Americas

Description: Fmoc-[D2]Gly-OH 1g, Molecular Formula: C17H13D2NO4, Storage Condition: Room Temperature, Cas number: 284665-11-8.

Supplier: Bachem Americas

Description: Substitution 0.50-0.90 mmol/g Storage Conditions -20 +/- 5 Deg C 5g

Supplier: Bachem Americas

Description: Nω-Methylation is a widespread post-translational modification of Arg-containing proteins. Arg(Me) can be conveniently introduced during the Fmoc-SPPS of model peptides using this derivative.

Supplier: Bachem Americas

Description: Boc-Oic-OH, (2S, 3aS, 7aS)-1-Boc-octahydro-1H-indole-2-carboxylic acid 1g, Cas number 109523-13-9, Storage Condition: -20 +/- 5 degree C

Catalog Number: (B-4120.0500BA)

Supplier: Bachem Americas

Description: Han et al. used Fmoc-(D₁₀)-Leu-OH for obtaining labeled Ac-WL₅, a hexapeptide forming β-sheets in membranes. The aggregation of the tagged peptide was followed by neutron scattering.

Catalog Number: (B-4085.0005BA)

Supplier: Bachem Americas

Description: These dipeptide building blocks containing Ser- or Thr-derived oxazolidines (pseudoprolines) proved to be versatile tools for overcoming some intrinsic problems in the field of peptide chemistry. The presence of pseudoprolines within a peptide sequence results in the disruption of β-sheet structures considered as a source of intermolecular aggregation during chain elongation, thus increasing solvation and coupling kinetics in peptide assembly. Therefore, use of pseudoprolines offer new possibilities for accessing large peptides by convergent strategies and chemoselective ligation techniques. Moreover, incorporation of a pseudoproline unit facilitates cyclization of peptides.

Catalog Number: (B-4305.0005BA)

Supplier: Bachem Americas

Description: These dipeptide building blocks containing Ser- or Thr-derived oxazolidines (pseudoprolines) proved to be versatile tools for overcoming some intrinsic problems in the field of peptide chemistry. The presence of pseudoprolines within a peptide sequence results in the disruption of β-sheet structures considered as a source of intermolecular aggregation during chain elongation, thus increasing solvation and coupling kinetics in peptide assembly. Therefore, use of pseudoprolines offer new possibilities for accessing large peptides by convergent strategies and chemoselective ligation techniques. Moreover, incorporation of a pseudoproline unit facilitates cyclization of peptides.

Supplier: Bachem Americas

Description: An alternative to Mob in the regioselective formation of disulfide bonds.

Supplier: Bachem Americas

Description: Bachem also offers derivatives of phosphoserine and sulfoserine.

Supplier: Bachem Americas

Description: Hepcidin-20, a degradation product of hepcidin-25 found in plasma and urine, shows an increased antimicrobial activity compared to the full-length peptide, but it is not involved in iron metabolism.

Supplier: Bachem Americas

Description: PG 97-269 is a selective high affinity VPAC1 receptor antagonist with negligible affinity for the PACAP type I receptor. The Ki values were 15 +/- 5 nM for the rat and 2 +/- 1 nM for the human VPAC1 receptors. PG 97-269 may be useful for the evaluation of the physiological role of VIP in rat and human tissues.

Supplier: Bachem Americas

Description: H-Tyr(tBu)-2-chlorotrityl resin (200-400 mesh) (Low Substitution) 1g, Substitution 0. 20-0. 49 mmol/g, Storage Condition: -20 +/- 5 degree C.

Supplier: Bachem Americas

Description: Please see also α-MSH (corresponds to acetyl-ACTH (1-13) amide, H-1075), α-MSH (free acid) (acetyl-ACTH (1-13), H-1070), and (Des-acetyl)-α-MSH (H-4390). Wied: Pituitary Adrenal System Hormones and Behaviour. Symposium on Developments in Endocrinology (1976) / Anon.: ACTH and Related Peptides: Structure, Regulation, and Action. Ann. N.Y. Acad. Sci. 297, 1 (1977) / A.V.Schally: Aspects of Hypothalamic Regulation of the Pituitary Gland. Science 202, 18 (1978) / R.Schwyzer: Studies on Polypeptide Receptors. A Critical View on the Mechanism of ACTH Action. Bull. Schweiz. Acad. Med. Wiss. 34, 263 (1978).