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You Searched For: Z-Gly-Gly-Phe-Chloromethylketone


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H-Cys-Arg-Gly-Asp-Phe-Pro-Ala-Ser-Ser-Cys-OH

Catalog Number: (H-2672.0001BA)
Supplier: Bachem Americas
Description: CRGDFPASSC is a cyclic RGD-containing decapeptide which binds to the fibrinogen receptor on the platelet surface. This analog with Phe substituted for Ser at position 5 was found to be 3 times more active (IC₅₀ = 2.5 µM) as a platelet aggregation inhibitor than CRGDSPASSC.
Product Image-89156-560

Cyclo [Arg-Gly-Asp-D-Phe-Val]

Catalog Number: (89156-560)
Supplier: Enzo Life Sciences
Description: Integrin αvβ3 antagonist. Inhibits cell adhesion events mediated by αvβ3. Inhibits angiogenesis. Induces rapid regression of histologically distinct human tumors. Induces apoptosis of angiogenic blood vessels.
Image Unavailable-M-1845.0250BA

FA-Gly-Phe-Leu-OH

Supplier: Bachem Americas
Description: The FA-peptides M-1400 and M-1410 are common ACE substrates and thus filed in the corresponding product family. For our 3-(2-furyl)acryloyl-amino acids (FA-amino acids) and the labeling reagent FA-OSu (Q-1245), please see the Amino Acids section.

Image Unavailable-CAAAJ61154-MF

Tyr-Gly-Gly-Phe-Met

Supplier: Thermo Scientific Chemicals
Description: Endogenous opioid peptide that also functions as a growth factor on many cell types at a receptor that is distinct from the neuronal opioid receptors.

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Image Unavailable-H-3495.0005BA

H-Gly-Gly-Tyr-OH

Supplier: Bachem Americas
Description: These short peptides act as angiotensin I-converting enzyme (ACE) inhibitors. See also Phe-Tyr (G-2955) and the subfamilies 'Bradykinin-Potentiating Peptide (BPP)' and 'Angiotensin I-Converting Enzyme (ACE, ACE2) Inhibitors'.

Image Unavailable-H-7226.0001BA

Cyclo(-Arg-Gly-Asp-D-Phe-Cys) Acetate

Supplier: Bachem Americas
Description: c(RGDfC), a RGD tumor-targeting peptide, which binds to αvβ3 receptors. c(RGDfC) can be easily conjugated to drugs as combretastatin or surfaces. For the control peptide c(RADfC) see H-7232

Image Unavailable-H-7326.0005BA

Cyclo(-Arg-Gly-Asp-D-Phe-Lys) Trifluoroacetate

Supplier: Bachem Americas
Description: An RGD tumor-targeting peptide, which binds to αvβ3 receptors. c(RGDfK) can be easily conjugated to fluorophore tags, chelators, or carriers. Palecek et al. converted the ε-amino group into the azide by diazo transfer allowing further functionalization by click chemistry. Mercapto groups can be introduced via acylation of c(RGDfK) with S-acetylthioacetic acid (SATA).

Image Unavailable-G-1715.0001BA

Cyclo(-Gly-Phe)

Supplier: Bachem Americas
Description: Also known as dioxopiperazines, piperazine-2,5-diones or DKPs. Diketopiperazines may occur as by-products during peptide synthesis or during the degradation of peptides. These cyclic dipeptides have been detected as taste-modulating compounds in food, they often show biological activity. DKPs are valuable chiral synthons, employed e.g. in Schöllkopf's versatile bislactim ether approach. They also have found use as catalysts for enantioselective synthesis, e.g. in the asymmetric Strecker reaction. See also the TRH metabolite cyclo(-His-Pro), G-1745, and cyclo(-Asp-Phe), G-1695, the major degradation product of aspartame.

Image Unavailable-H-2574.0001BA

Cyclo(-Arg-Gly-Asp-D-Phe-Val) Trifluoroacetate

Supplier: Bachem Americas
Description: c(RGDfV) is a potent inhibitor of cell adhesion. It inhibited tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats provided the first evidence of its utility in the amelioration of ischemic acute renal failure. c(RGDfV) inhibited tubular obstruction by preventing cell-cell adhesion. Hammes et al. showed that the cyclopeptide can also be used to prevent retinal neovascularization. c(RGDfV) binds to αvβ3 receptors.

Image Unavailable-B-1495.0005BA

Fmoc-Gly-Phe-OH

Supplier: Bachem Americas
Description: For Fmoc-dipeptides Fmoc-Xaa-Gly-OH and Fmoc-Xaa-Pro-OH, which can be used as building blocks in Fmoc-SPPS, please see also the subfamily 'Fmoc-Dipeptide Building Blocks' in the 'Amino Acid Derivatives' section. Pseudoproline dipeptides and isoacyl dipeptides can be found in this section as well. In case of a strong tendency towards diketopiperazine formation during Fmoc-SPPS, Fmoc-dipeptides have been coupled even at the risk of a some epimerization.

Image Unavailable-M-2295.0001BA

Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH₂ Trifluoroacetate

Catalog Number: (M-2295.0001BA)
Supplier: Bachem Americas
Description: Ac-ED(edans)KPILFFRLGK(dabcyl)E-amide, a sensitive fluorescent (FRET) peptide substrate for cathepsin D. This enzyme can degrade extracellular matrix components and may facilitate the spread of tumor cells. High levels of active cathepsin D were found within senile plaques in brains of Alzheimer's patients.
Image Unavailable-G-2340.0250BA

H-His-Ser-OH

Supplier: Bachem Americas
Description: The 1:1 complex of histidylserine with Co(II)(Cys-Gly) was shown to cleave DNA by hydrolysis at physiological pH. Cleavage has also been observed employing the analogous Co complex with His-Phe (N-1095).

Image Unavailable-G-1705.0001BA

Cyclo(-Gly-His)

Catalog Number: (G-1705.0001BA)
Supplier: Bachem Americas
Description: Also known as dioxopiperazines, piperazine-2,5-diones or DKPs. Diketopiperazines may occur as by-products during peptide synthesis or during the degradation of peptides. These cyclic dipeptides have been detected as taste-modulating compounds in food, they often show biological activity. DKPs are valuable chiral synthons, employed e.g. in Schöllkopf's versatile bislactim ether approach. They also have found use as catalysts for enantioselective synthesis, e.g. in the asymmetric Strecker reaction. See also the TRH metabolite cyclo(-His-Pro), G-1745, and cyclo(-Asp-Phe), G-1695, the major degradation product of aspartame.
Image Unavailable-B-2150.0001BA

Fmoc-Phe-Phe-OH

Supplier: Bachem Americas
Description: For Fmoc-dipeptides Fmoc-Xaa-Gly-OH and Fmoc-Xaa-Pro-OH, which can be used as building blocks in Fmoc-SPPS, please see also the subfamily 'Fmoc-Dipeptide Building Blocks' in the 'Amino Acid Derivatives' section. Pseudoproline dipeptides and isoacyl dipeptides can be found in this section as well. In case of a strong tendency towards diketopiperazine formation during Fmoc-SPPS, Fmoc-dipeptides have been coupled even at the risk of a some epimerization.

Image Unavailable-A-3205.0005BA

Boc-Phe-Phe-OH

Catalog Number: (A-3205.0005BA)
Supplier: Bachem Americas
Description: For Boc-dipeptides Boc-Xaa-Gly-OH and Boc-Xaa-Pro-OH, which can be used as building blocks during Boc-SPPS, please see the product family 'Boc-Dipeptide Building Blocks' in the 'Amino Acid Derivatives' section. This family also includes short protected peptide fragments suitable for solution synthesis and preparation of enzyme substrates and inhibitors.
Image Unavailable-H-6046.0005BA

Mouse (Ala¹)-PAR-4 (1-6) amide Trifluoroacetate

Supplier: Bachem Americas
Description: This peptide based on the proteolytically-revealed tethered ligand sequence of the murine proteinase-activated receptor-4 (PAR-4) was shown to cause platelet aggregation with an EC50 value of about 15 µM.
Sequence: H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2
Salt: Trifluoroacetate

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