You Searched For: Tyrphostin+AG+1024


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Supplier: Enzo Life Sciences
Description: Specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor kinases. Induces apoptosis by downregulation of the expression of phospho-Akt1 and Bcl-2. Also increases Bax, p53 and p21 expression.

Catalog Number: (89147-104)
Supplier: Enzo Life Sciences
Description: Selective inhibitor of tyrosine kinase in platelet-derived growth factor (PDGF) receptor.


Catalog Number: (89147-108)
Supplier: Enzo Life Sciences
Description: EGFR inhibitor


Catalog Number: (89157-734)
Supplier: Enzo Life Sciences
Description: A potent inhibitor of EGF receptor kinase activity (IC50‘s:EGFR = 2.4 µM, PDGFR = 3.5 µM, p210bcr-abl=5.9 µM, insulin receptor = 640 µM).


Catalog Number: (89147-260)
Supplier: Enzo Life Sciences


Supplier: Enzo Life Sciences
Description: AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling.

Supplier: Enzo Life Sciences
Description: NGF receptor inhibitor

Supplier: Enzo Life Sciences
Description: AG-490 is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. At 5 µM, AG-490 almost completely blocked the growth of all pre-B ALL cells but had no significant effect on the growth of mitogen-stimulated normal B or T cells, B-cell lymphoma or T-cell leukemia cells. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. It blocks interleukin-7-induced JAK kinase activity in T-cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. AG-490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.

Catalog Number: (89157-738)
Supplier: Enzo Life Sciences
Description: A potent inhibitor of EGF receptor kinase activity (IC50=0.8 µM). Inhibition is mixed competitive with ATP and substrate.


Catalog Number: (CA80054-862)
Supplier: MilliporeSigma
Description: AG 538 inhibitors are potent, cell-premeable, reversible, and competitive inhibitor of IGF-1 receptor kinase

Catalog Number: (CAAAJ65227-MA)
Supplier: Thermo Scientific Chemicals
Description: A selective ErbB2 inhibitor


Supplier: Enzo Life Sciences
Description: A potent inhibitor of PDGF receptor tyrosine kinase (IC50=1 µM). Also inhibits FGF receptor tyrosine kinase and c-kit. Induces apoptosis in a small-cell lung cancer cell line (H526).

Supplier: Enzo Life Sciences
Description: An inactive tyrphostin, which may be used as a negative control.

Supplier: Enzo Life Sciences
Description: Member of the tyrphostin family of tyrosine kinase inhibitors. Selective inhibitor of the PDGF receptor kinase (IC50=20µM) vs. the EGF receptor kinase (IC50=820µM). Inhibits PDGF-induced mitogenesis in human bone marrow fibroblasts.

Supplier: TCI America
Description: Tyrphostin AG 494, Purity: >98.0%(HPLC)(N), Cas number: 133550-35-3, Molecular Formula: C16H12N2O3, Molecular Weight: 280.28, Appearance: Pale yellow - Deep yellow green solid crystal powder, Synonyms: (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenylacrylamide, Size: 20MG

SDS

Supplier: TCI America
Description: Tyrphostin A1, Purity: >98.0%(GC), Cas number: 2826-26-8, Molecular Formula: C11H8N2O, Molecular Weight: 184.20, Synonyms: (4-Methoxybenzylidene)malononitrile, Tyrphostin 1, Appearance: Slightly pale yellow - Yellow solid crystal powder, Size: 1G

SDS

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