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Catalog Number: (89416-816)
Supplier: Prosci
Description: JPH3 Antibody: Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain. In the CNS, both JPH3 and JPH4 are expressed throughout neural sites and contribute to the subsurface cistern formation in neurons. Mice lacking both JPH3 and JPH4 subtypes exhibit serious symptoms such as impaired learning and memory and are accompanied by abnormal nervous functions. A repeat expansion in JPH3 is associated with Huntington disease-like 2. At least two isoforms of JPH3 are known to exist.


Supplier: Abcam
Description: Rabbit monoclonal [EPR26383-85] to KCNA.

New Product

Supplier: Abcam
Description: Rabbit monoclonal [EPR23502-85] to CCR4 - BSA and Azide free.

New Product

Supplier: Abcam
Description: Rabbit monoclonal [EPR28732-85] to CLUH - BSA and Azide free.

New Product

Supplier: TCI America
Description: CAS Number: 92-85-3
MDL Number: MFCD00005065
Molecular Formula: C12H8S2
Molecular Weight: 216.32
Purity/Analysis Method: >98.0% (GC)
Form: Crystal
Color: White
Melting point (°C): 156
Supplier: Abcam
Description: Rabbit monoclonal [EPR24203-85] to KCC2 - BSA and Azide free.

New Product

Catalog Number: (10494-048)
Supplier: Bioss
Description: Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The FAM80A gene product has been provisionally designated FAM80A pending further characterization.


Catalog Number: (76953-808)
Supplier: ANTIBODIES.COM LLC
Description: Mouse monoclonal [85-2C8] antibody to BrdU for Flow Cytometry, IF and IHC-P.


Supplier: TCI America
Description: CAS Number: 544-85-4
MDL Number: MFCD00009411
Molecular Formula: C32H66
Molecular Weight: 450.88
Purity/Analysis Method: >96.0% (GC)
Form: Crystal
Boiling point (°C): 220
Melting point (°C): 70
Flash Point (°C): 243
Catalog Number: (10094-414)
Supplier: Proteintech
Description: SIRT6, also named as SIR2L6, belongs to the sirtuin family. SIRT6 is a member of a highly conserved family of NAD+-dependent deacetylases with various roles in metabolism, stress resistance, and life span. It has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. SIRT6 modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. SIRT6 may be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. It is required for genomic stability. And it is required for normal IGF1 serum levels and normal glucose homeostasis. It modulates cellular senescence and apoptosis. It regulates the production of TNF protein. SIRT6 acts as a histone deacetylase to directly repress multiple glycolytic genes. SIRT6 also functions as a corepressor of the transcription factor Hif1α. Loss of SIRT6 increases glycolysis and diminishes mitochondrial respiration. SIRT6 plays a key role in regulating glucose homeostasis.


Catalog Number: (TCD0977-025G)
Supplier: TCI America
Description: CAS Number: 2561-85-5
MDL Number: MFCD00022610
Molecular Formula: C16H28O3
Molecular Weight: 268.40
Purity/Analysis Method: >95.0% (GC,T)
Form: Crystal
Melting point (°C): 73

Supplier: Abcam
Description: Rabbit monoclonal [EPR24883-85] to RIP.

New Product

Supplier: Avantor
Description: Avantor® Partisil® was one of the first commercially available irregular silicas with a large surface area giving it a high loading capacity.

Supplier: Avantor
Description: Avantor® Partisil® was one of the first commercially available irregular silicas.

Supplier: TCI America
Description: CAS Number: 85-36-9
MDL Number: MFCD00016495
Molecular Formula: C9H6I3NO3
Molecular Weight: 556.86
Purity/Analysis Method: >98.0% (T)
Form: Crystal
Supplier: TCI America
Description: CAS Number: 2381-85-3
MDL Number: MFCD00011936
Molecular Formula: C20H20ClN3O
Molecular Weight: 353.85
Form: Crystal
Color: Deep Yellow Green
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