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Image Unavailable-10447-528

Anti-CASP8 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10447-528)
Supplier: Bioss
Description: Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
Image Unavailable-10447-532

Anti-CASP8 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10447-532)
Supplier: Bioss
Description: Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
Image Unavailable-10447-526

Anti-CASP8 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10447-526)
Supplier: Bioss
Description: Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
Image Unavailable-CAAAAL08956-06

4-Benzyl-L-aspartate 98%

Supplier: Thermo Scientific Chemicals
Description: 4-Benzyl-L-aspartate 98%

Certificates

Image Unavailable-76116-350

Anti-Caspase-8 subunit p18 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76116-350)
Supplier: Bioss
Description: Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
Image Unavailable-CAAAJ61361-MF

N-Methyl-D-aspartic acid ≥98%

Supplier: Thermo Scientific Chemicals
Description: Powder

Certificates

Image Unavailable-CAAA43317-36

L(+)-Aspartic acid 99% low metals

Supplier: Thermo Scientific Chemicals
Description: MDL: MFCD00002616 Beilstein Registry No.: 1723530 Notes: Specific rotation (4%, 6NHCl) +24.5°C to 26.0°C, As less than 10ppm, Feless than 20ppm

Certificates

Image Unavailable-TCA0997-025G

Aspartame

Supplier: TCI America
Description: Product Categories: Bioscience, Obesity/Diabete Research Reagents, Oligopeptides, Amino Acids (C-Protected)
Other Product Names / Synonyms: N-L-alpha-Aspartyl-L-phenylalanine 1-Methyl Ester, H-Asp-Phe-OMe

SDS Certificates

Image Unavailable-CAAAAB24859-14

L-Glutamic acid 5-methyl ester 99%

Supplier: Thermo Scientific Chemicals
Description: L-Glutamic acid 5-methyl ester 99%

Certificates

Image Unavailable-CA80050-828

Calbiochem® Caspase-4 Inhibitor I

Catalog Number: (CA80050-828)
Supplier: MilliporeSigma
Description: A caspase-4 (ICH-2) inhibitor.

SDS


Image Unavailable-CAAAAL03764-14

Dimethyl-L-glutamate hydrochloride ≥97%

Supplier: Thermo Scientific Chemicals
Description: Dimethyl-L-glutamate hydrochloride ≥97%

Certificates

Image Unavailable-CA80050-774

Calbiochem® Caspase Inhibitor II

Catalog Number: (CA80050-774)
Supplier: MilliporeSigma
Description: A potent and reversible inhibitor of caspase-1 (ICE), caspase-3, caspase-4, and caspase-7.

Certificates


Image Unavailable-CA80050-782

Caspase-1 Substrate X, Fluorogenic, Calbiochem®

Catalog Number: (CA80050-782)
Supplier: MilliporeSigma
Description: A fluorogenic substrate for detecting caspase-1 (ICE), caspase-4, and caspase-5 activity

Certificates


Image Unavailable-CA80050-852

Caspase-9 Substrate I, Fluorogenic, Calbiochem®

Supplier: MilliporeSigma
Description: A fluorogenic substrate for caspase-9 (ICE-LAP6, Mch6)

Image Unavailable-CA80051-940

Granzyme B Substrate I, Colorimetric, Calbiochem®, MilliporeSigma

Catalog Number: (CA80051-940)
Supplier: MilliporeSigma
Description: Colorimetric substrate for the detection of granzyme B and caspase-8 activity. Cleavage of pNA is monitored colorimetrically at ~405nm.

SDS


Image Unavailable-CA80052-272

Calbiochem® Caspase-1 Inhibitor II

Catalog Number: (CA80052-272)
Supplier: MilliporeSigma
Description: A cell-permeable and irreversible inhibitor of caspase-1 (Ki=760pM) and caspase-4

Certificates


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