You Searched For: Enzo Life Sciences

Catalog Number: (89141-230)

Supplier: Enzo Life Sciences

Description: For the measurement of glutathione peroxidase in cell lysates, plasma, and tissue from any species.

Catalog Number: (89141-152)

Supplier: Enzo Life Sciences

Description: Certified for a large variety of sample types for steroid and hormone research.

Catalog Number: (89141-112)

Supplier: Enzo Life Sciences

Description: For the quantitative determination of testosterone in culture supernatants, plasma, serum, and saliva from any species

Catalog Number: (89141-102)

Supplier: Enzo Life Sciences

Description: Sensitive ELISA kit enabling detection of 12(S)-HETE in culture supernatants and plasma from any species.

Catalog Number: (89141-140)

Supplier: Enzo Life Sciences

Description: For the quantitative determination of 11-dehydro-TXB2 in culture supernatants and urine from any species

Catalog Number: (89141-128)

Supplier: Enzo Life Sciences

Description: The GRO/CINC-1 (Rat), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in 2 hours

Catalog Number: (89141-368)

Supplier: Enzo Life Sciences

Description: Adipose tissue is the source for a variety of bioactive molecules that regulate metabolism and immunity termed adipokines, most of which are elevated in the circulation of obese individuals. Adiponectin functions as an insulin sensitizing factor, resulting in reduced hepatic glucose production, increased glucose uptake in the muscle, and increased fatty acid oxidation in the liver and muscle. In contrast to most adipokines, adiponectin is detected at high levels in normal human plasma, but is often reduced in obese subjects and in those with increased insulin resistance and type 2 diabetes. Due to its suggested protective role in insulin resistance, adiponectin may be a useful pharmacological target for various metabolic diseases.

Catalog Number: (89141-302)

Supplier: Enzo Life Sciences

Description: For the quantitative determination of 15(S)-HETE in culture supernatants, plasma, serum, and urine from any species.

Catalog Number: (89141-318)

Supplier: Enzo Life Sciences

Description: Highly sensitive ELISA kit enabling detection of LTC4/D4/E4 in 4 hours.

Catalog Number: (89141-076)

Supplier: Enzo Life Sciences

Description: For the quantitative determination of mouse leptin in culture supernatants, plasma, and serum

Catalog Number: (89141-060)

Supplier: Enzo Life Sciences

Description: For the quantitative determination of 17β-Estradiol in culture supernatants and saliva from any species

Catalog Number: (89141-658)

Supplier: Enzo Life Sciences

Description: Species Independent

Catalog Number: (89141-478)

Supplier: Enzo Life Sciences

Description: The octapeptide circulatory hormone Angiotensin II is a critical regulator of cardiovascular homeostasis formed in blood, with dual function in tissues of the brain, kidney, heart, and vasculature as an autocrine/paracrine growth hormone. The actions of angiotensin II are mediated by type one (AT1) and type two (AT2) angiotensin II receptors, members of the seven-transmembrane Gprotein coupled receptor (GPCR) family. AT1 receptors couple predominantly with Gq/11 alpha subunits, and signal through phospholipases C, D, and A2, inositol phosphates, and calcium channels, as well as a variety of serine/threonine and tyrosine kinases. AT1 expression is greatest in vascular smooth muscle, liver, kidney, adrenal cortex, brain, and lung, and is primarily responsible for the physiological effects of angiotensin II, including regulation of arterial blood pressure, electrolyte and water balance, thirst, hormone secretion, and renal function. The AT2 receptor displays approximately 30% identity to the AT1 receptor, and is highly expressed during embryonic development. AT2 expression in adult tissue is limited to the adrenal medulla, brain, and reproductive tissues, but is upregulated in injured tissue following myocardial infarction, vascular injury, and wound healing. AT2 receptor signaling is not dependent on G-protein coupling or receptor phosphorylation, although coupling to Gia2 and Gia3 alpha subunits occurs in some tissues. AT2 activation can stimulate tyrosine and serine/threonine phosphatases through activation of nitric oxide and cGMP, and appears to counteract the stimulatory effects of AT1 receptor and growth factor receptor signaling.

Catalog Number: (89141-470)

Supplier: Enzo Life Sciences

Description: The beta-amyloid peptide (beta A4), proteolytically released from the amyloid precursor protein (APP), provides the principal component of senile plaques in Alzheimer's disease. Cleavage of APP by alpha-secretase or alternatively by beta-secretase leads to generation and extracellular release of soluble APP peptides, S-APP-alpha and S-APP-beta, respectively, and the retention of corresponding membrane-anchored C-terminal fragments, C83 and C99. Subsequent processing of C83 by gamma-secretase yields P3 peptides. This is the major secretory pathway and is nonamyloidogenic. Alternatively, presenilin/ nicastrin-mediated gamma-secretase processing of C99 releases the amyloid beta proteins, amyloid-beta 40 (Abeta40) and amyloid-beta 42 (Abeta42), major components of amyloid plaques, and the cytotoxic C-terminal fragments, gamma-CTF(50), gamma-CTF(57) and gamma-CTF(59).

Catalog Number: (89141-652)

Supplier: Enzo Life Sciences

Description: The cannabinoid receptors CB1 (expressed primarily throughout the central nervous system) and CB2 (expressed in peripheral tissues) are members of the seven-transmembrane domain-containing family of G-protein coupled receptors (GPCRs), and are named for their signaling function in response to cannabinoid drugs such as delta-9-tetrahydrocannabinol (delta-9-THC). Significant evidence suggests that additional cannabinoid receptors may contribute to the many behavioral, vascular, and immunological effects of agonists such as THC and endogenous cannabinoids. Evidence suggests GPR55 may act as a cannabinoid receptor, although its definition as a bona fide "CB3" receptor remains controversial. GPR55 is highly expressed in large-diameter dorsal root ganglion (DRG) neurons, and its activation by cannabinoid compounds (THC, JWH015, and anandamide) has been shown to release calcium from IP3-sensitive ER stores. These findings are opposed by evidence that suggests GPR55 is an intrinsic receptor for lysophosphatidylinositol (LPI).

Catalog Number: (89141-648)

Supplier: Enzo Life Sciences

Description: The subtype 1 neurotensin receptor (NTS1) is a seven-transmembrane domain containing G protein coupled receptor (GPCR) that mediates most of the known effects of neurotensin. NTS1 activates a phosphatidylinositol-calcium second messenger system in the central and peripheral nervous systems, mediating such functions as hypotension, hyperglycemia, hypothermia, antinociception, and the regulation of intestinal motility and secretion. NTS1 signaling is primarily mediated via coupling to Gq/G11 family G proteins, although coupling of NTS1 through Gs and Gi/o family proteins has been shown to modulate both adenylate and guanylate cyclase activity.