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Supplier: Diagnostic Biosystems

Description: This antibody is specific to a cluster of proteins between 70 to 80 kDa known as tyrosinase. This antibody does not show any cross-reaction with MAGE-1 and tyrosinase-related protein-1, TRP-1/gp75. Staining of melanomas with this antibody showed tyrosinase in melanotic as well as amelanotic variants.

Supplier: Diagnostic Biosystems

Description: Mesothelin is a glycocylphosphotidylianositol-linked cell-surface glycoprotein, which is present on the surface of normal mesothelium and is overexpressed in many patients with epithelial ovarian cancer and malignant mesotheliomas.

Supplier: Diagnostic Biosystems

Description: Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S transition. Amplification or overexpression of Cyclin D1 plays a pivotal role in the development of various human cancers including breast cancer, colon cancer, melanoma, prostate cancer and lymphoma. It is useful to differentiate mantle cell lymphoma from small cleaved cell lymphoma. Rabbit monoclonal antibodies to Cyclin D1 showed the highest sensitivity to detect this antigen in formalin fixed paraffin embedded tissue as compared to several other clones.

Supplier: Diagnostic Biosystems

Description: This antibody is specific against an epitope located on the β chain (i.e., in S-100a and S-100b) but not on the α chain of S-100 (i.e., in S-100a and S-100ao). This antibody can be used to localize S-100a and S-100b in various tissue sections.

Supplier: Diagnostic Biosystems

Description: This antibody reacts specifically with CA 125 ovarian cancer antigen. Several studies have shown that CA 125 is a useful tumor marker for ovarian epithelial malignancies. However, CA 125 has been described in other neoplasms such as seminal vesicle and anaplastic lymphomas.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a glycoprotein of MW 110 kDa, present on the surface of hematopoietic cells i.e. myeloid and lymphoid progenitors. It stains the vascular endothelial cells.

Catalog Number: (CA76634-598)

Supplier: Diagnostic Biosystems

Description: A20 Antibody (A-12) is a high quality monoclonal A20 antibody (also designated TNFAIP3 antibody, or TNF a induced protein 3 antibody). A20 is induced by tumor necrosis factor (TNF) and interleukin 1 (IL-1) and acts as a negative regulator of nuclear factor k B (NFkB) gene expression. By inhibiting NFkB activation, A20 plays a critical role in terminating NFkB responses to various stimuli. Although the C-terminal region of A20 contains seven zinc finger domains, only four of these domains are required for in vitro inhibition of TNF-induced NFkB activation. A20 also interacts with several other proteins, such as TRAF2, TRAF6 and IkB kinase (IKK) g protein, and can thereby inhibit cell death. TXBP151, a novel A20-binding protein, may mediate the anti-apoptotic activity of A20. Involved in the negative feedback regulation of signal transduction, A20 and A20-binding proteins may be useful as novel therapeutic tools in the treatment of a variety of diseases.

Catalog Number: (CA76634-330)

Supplier: Diagnostic Biosystems

Description: This antibody recognizes keratin polypeptides of 68, 58, 56.5 and 50 kDa in the stratum corneum. The antibody reacts with squamous, ductal and other complex epithelia. It stains adenocarcinomas, breast, pancreas, bile duct, salivary gland and transitional cell carcinomas.

Catalog Number: (CA76634-252)

Supplier: Diagnostic Biosystems

Description: Anti-CD1A Cortical Thymocytes Antibody

Supplier: Diagnostic Biosystems

Description: This antibody stains a 60 kDa peptide in human lymphoblasts. TdT is present in the cells during immunoglobulin gene rearrangement and plays an important role in lymphocyte maturation. TdT marks both T and B immature lymphocytes normally found in thymus and bone marrow.

Supplier: Diagnostic Biosystems

Description: MOC-31 antibody recognizes an epithelial-associated, glycoprotein located on the cell membrane surface and in the cytoplasm of virtually all epithelial cells. It is not present in most squamous epithelia, hepatocytes, renal proximal tubular cells, gastric parietal cells and myoepithelial cells. MOC-31 may be used in a panel of antibodies as a negative marker for mesothelioma, or lung adenocarcinoma. Studies have shown that MOC31 is useful in differentiating tumors of unknown origin in liver cancers and distinguishing Cholangiocarcinoma from Hepatocellular Carcinomas.

Catalog Number: (CA76634-402)

Supplier: Diagnostic Biosystems

Description: The HMB45 clone reacts with a neuraminidase-sensitive oligosaccharide side chain of a glycoconjugate present in immature melanosomes. The HMB45-reactive antigen is present in cutaneous melanocytes, prenatal and infantile retinal pigment epithelium and melanoma cells and is thought to be oncofetal in nature. This antibody has been shown to label the majority of melanomas. Clone A103 recognizes a protein of 20 kDa, identified as MART-1 (melanoma antigen recognized by T cells-1) or Melan-A. Melan-A is a useful addition to melanoma panels as it is apparently specific for melanocytic lesions. Studies have also shown that MART-1 is more sensitive than HMB45 when labeling metastatic melanomas. Tyrosinase is a key enzyme involved in the initial stages of melanin biosynthesis. Studies have shown tyrosinase to be a more sensitive marker when compared to HMB45 and MART-1. It has been shown to label a higher percentage of desmoplastic melanomas than HMB45. The combination of HMB45, MART-1 and tyrosinase make this triple antibody cocktail a first-order pan melanoma screener.

Catalog Number: (CA76634-360)

Supplier: Diagnostic Biosystems

Description: This antibody recognizes human retinoblastoma gene protein. Rb gene, a prototype of tumor suppressor genes, has been associated with development and/or progression of bladder cancer as well as sarcoma and small cell lung cancer. Functional Rb gene loss has been reported to occur in bladder cancer and osteosarcoma. A significantly poorer tumor-free survival rate was noted for those patients who had a tumor with an altered Rb protein with or without vascular invasion.

Catalog Number: (CA76634-310)

Supplier: Diagnostic Biosystems

Description: This antibody reacts with free as well as bound kappa light chains. Contaminating antibodies have been removed by solid phase adsorption.

Catalog Number: (CA76634-304)

Supplier: Diagnostic Biosystems

Description: Cytokeratin 20 is less acidic than the other type I cytokeratins and is of particular interest because of its restricted range of expression. This antibody reacts with cytokeratin polypeptide of 46 kDa in immunoblot analyses. Studies have shown that a marked difference exists in the expression of Cytokeratin 20 among various carcinomas.

Catalog Number: (CA76634-512)

Supplier: Diagnostic Biosystems

Description: Monoclonal anti-bcl-10 reacts specifically with human bcl-10. The epitope recognized by the antibody resides within amino acids 122-168 of human bcl-10 molecule. Bcl-10, also designated as CIPER, mE10, cE10, CARMEN, and CLAP, is an N-terminal CARD (caspase recruitment domain) containing protein. It is a cellular homologue of the equine herpesvirus-2 protein E-10 (vCLAP). Bcl-10 was implicated in the regulation of apoptosis by interacting with caspase 9, enhancing procaspase 9 processing, and triggering its activation when overexpressed in the cell. Bcl-10 cellular overexpression induces JNK, p38, and NF-kB activation. Deregulation of bcl-10 expression was also demonstrated to be involved in cellular oncogenesis.