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Image Unavailable-D-1675.0005BA

Rink amide AM resin 200-400 mesh

Supplier: Bachem Americas
Description: Fmoc-Rink amide-AM resin, a standard resin for the Fmoc-SPPS of peptide amides. Cleavage was performed with 50 % TFA in CH₂Cl₂ or 95% aqueous TFA. Scavengers may be required. Bachem additionally offers the Rink amide (RAM) linker (Q-1660).

Image Unavailable-D-2080.0005BA

4-(2',4'-Dimethoxyphenyl-fmoc-aminomethyl)phenoxymethyl on polystyrene 0.80-1.20 mmol/g 200-400 mesh

Supplier: Bachem Americas
Description: Resin for the Fmoc-SPPS of peptide amides. Cleavage was achieved with 50 % TFA in CH₂Cl₂. or 95% TFA Scavengers may be required. (EP 0 285 562 B1 licensed to Bachem)

Image Unavailable-TCD2672-5G

4-[(2,4-Dimethoxyphenyl)-(fmoc-amino)methyl]phenoxyacetic acid ≥98.0% (by HPLC, titration analysis)

Catalog Number: (TCD2672-5G)
Supplier: TCI America
Description: CAS Number: 126828-35-1 MDL Number: MFCD00153509 Molecular Formula: C32H29NO7 Molecular Weight: 539.58 Purity/Analysis Method: <gt/>98.0% (HPLC,T) Form: Crystal Melting point (°C): 180 Storage Temperature: 0-10°C

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Image Unavailable-D-2200.0025BA

Tricyclic amide linker resin (DL-form) 200-400 mesh

Supplier: Bachem Americas
Description: Ramage resin is highly suitable for the preparation of peptide amides by the Fmoc-strategy and is recommended for C-terminal Phe, Tyr and Ile. Cleavage has been performed with 50 % TFA in CH₂Cl₂ or 95% aqueous TFA. Scavengers may be required. Tricyclic amide linker resin has been used for the synthesis of fluorogenic substrates for continuous assay of aminopeptidase P. Bachem additionally offers the Ramage amide linker (Q-2745) to be coupled to other types of carrier resin.

Image Unavailable-D-2040.0005BA

Xanthenyl linker resin 200-400 mesh

Supplier: Bachem Americas
Description: Sieber amide resin has been developed for the Fmoc-SPPS of fully t-butyl protected peptide amides. Cleavage can be achieved with 1% TFA in methylene chloride. Scavengers may be required. As N-methylation increases the acid-lability of the peptide bond, Malakoutikhah et al. employed Sieber resin for obtaining short peptide amides containing multiple MePhe residues.

Image Unavailable-D-2125.0001BA

PAL (Peptide Amide Linker) resin 200-400 mesh

Catalog Number: (D-2125.0001BA)
Supplier: Bachem Americas
Description: Useful for the synthesis of peptide amides using Fmoc strategy. Cleavage has been performed with 50 % TFA in CH₂Cl₂ or 95% aqueous TFA. Scavengers may be required.
Image Unavailable-D-2570.0005BA

4-Formyl-3-methoxyphenyloxymethyl on polystyrene resin 200-400 mesh

Supplier: Bachem Americas
Description: For Fmoc solid phase synthesis of N-alkyl peptide amides by reductive amination.

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Lithiumbis(trimethylsilyl)amide 0.9-1.1 M in hexane

Supplier: Thermo Scientific Chemicals
Description: Lithiumbis(trimethylsilyl)amide 0.9-1.1 M in hexane

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Image Unavailable-CAAAAL08779-AP

Sodium bis(trimethylsilyl)amide 1 M in THF

Supplier: Thermo Scientific Chemicals
Description: Fieser: 1,1046 3,261 4,442 6,529 7,329 12,441 18,332 20,349 21,401

Certificates

Image Unavailable-CAAAAL13352-AE

Sodium bis(trimethylsilyl)amide 2 M in THF

Supplier: Thermo Scientific Chemicals
Description: Fieser: 1,1046 3,261 4,442 6,529 7,329 12,441 18,332 20,349 21,401

Certificates

Product Image-CA95017-030

NHS-Activated Sepharose™ 4 Fast Flow Affinity Coupling Media, Cytiva

Catalog Number: (CA95017-030)
Supplier: Cytiva
Description: NHS-activated Sepharose™ 4 Fast Flow is composed of cross-linked 4% agarose beads, NHS activated for coupling amino-containing proteins and peptides in process-scale applications. NHS (N-hydroxysuccinimide) coupling forms a chemically stable amide bond with ligands containing primary amino groups. The resin provides a spacer arm to the coupled ligand and suitable for immobilising smaller protein and peptide ligands.

SDS Certificates


Image Unavailable-D-1250.0100BA

Wang resin 200-400 mesh

Supplier: Bachem Americas
Description: The Wang support, p-benzyloxybenzyl alcohol resin, is the most widely used resin for attaching carboxylic acids for further functionalization. Cleavage conditions for the ester anchor involve concentrated TFA or TFA/CH₂Cl₂ to provide carboxylic acids or cyclization-cleavage under acidic or basic conditions. Release of an amide function by treatment with an amine in the presence of a Lewis acid was also reported. Wang resin was used to add vinyl and iodobenzoic acids via carbodiimide coupling and the products subjected to Heck conditions with alkenes or with alkynes or to Suzuki coupling with boron reagents. The Ugi multicomponent condensation reaction was conducted on Wang resin with the carboxylic acid, amine or isonitrile as the anchored functional group. Solid-phase lactam syntheses were also achieved by reaction of the resin-bound isonitrile with an amine and an ω-keto-acid as well as other synthetic transformations such as the Biginelli reaction and construction of heterocycles such as quinolones, imidazoles, hydantoins, and 1,4-benzodiazepine-2,5-diones. On a Wang resin primary, secondary, and tertiary alcohols have been converted to 4-methoxybenzyl ethers. As well as anchoring carboxylic acids to Wang resin, phenols were attached under Mitsunobu conditions, subjected to further transformations and cleaved under acidic conditions.

Image Unavailable-89139-180

FLUO 3/AM ≥95% (by HPLC) fluorescent indicator, for calcium determination

Supplier: Biotium
Description: Membrane-permeant AM ester form of Fluo-3 that can be loaded into cells via incubation. Fluo-3 AM ester itself does not bind Ca2 , but it is readily hydrolyzed to Fluo-3 by endogenous esterases once the dye is inside the cells. An important application of Fluo-3 AM ester is its use in high throughput drug screening.

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Calcein AM ≥95% (by HPLC), Ultra Pure Grade fluorescent dye

Supplier: Anaspec Inc
Description: Calcein, AM is a cell-permeant and non-fluorescent compound that is widely used for determining cell viability

Image Unavailable-89139-206

Fura 2-AM ≥98% (by HPLC) fluorescent indicator, for calcium determination

Supplier: Biotium
Description: Fura-2, AM ester is a ratiometric fluorescent dye that binds to free intracellular calcium, and is the preferred dye for ratiometric imaging microscopy. Fura-2, AM ester is membrane-permeant and thus can be loaded into cells via incubation.

Image Unavailable-89139-472

Calcein AM 1 mg/mL in anhydrous DMSO fluorescent dye, for histology

Catalog Number: (89139-472)
Supplier: Biotium
Description: Calcein AM is a widely used green fluorescent cell marker. Calcein AM is membrane-permeant and thus can be introduced into cells via incubation.

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