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Product Image-10087-524

Anti-GGCX Rabbit Polyclonal Antibody

Catalog Number: (10087-524)
Supplier: Proteintech
Description: GGCX(Gamma-glutamyl carboxylase) is also named as GC and belongs to the vitamin K-dependent gamma-carboxylase family. This 94 kDa (including all modifications, such as the five N-linked glycosylations), is a 5-pass transmembrane protein and a key regulator of blood coagulation. It mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. Defects in GGCX are a cause of combined deficiency of vitamin K-dependent clotting factors type 1 (VKCFD1) and pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency (PXEL-MCFD).
Image Unavailable-10772-776

Human Recombinant PEDF (from E. coli)

Supplier: Peprotech
Description: PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors, such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity ( Notari, I. et al. J Biol Chem., Vol. 281, 38022-38037 ) should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities implicate it as a potential therapeutic agent for the treatment of vasculature-related neurodegenerative diseases, such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF also has the potential to be useful in the treatment of various angiogenesis-related diseases including a number of cancers. Recombinant Human PEDF is a 44.5 kDa non-glycosylated protein containing 400 amino acid residues.

Product Image-10109-730

Anti-EBP Rabbit Polyclonal Antibody

Catalog Number: (10109-730)
Supplier: Prosci
Description: EBP is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in EBP gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome).Emopamil-binding protein (EBP) is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. EBP shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of EBP is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome).
Image Unavailable-TCM1487-5G

Methyl-2,3,4-tri-O-benzoyl-ɑ-D-glucopyranoside ≥98.0% (by HPLC)

Supplier: TCI America
Description: CAS Number: 34234-44-1
MDL Number: MFCD06797128
Molecular Formula: C28H26O9
Molecular Weight: 506.51
Purity/Analysis Method: >98.0% (HPLC)
Form: Crystal
Melting point (°C): 146
Specific rotation [a]20/D: 53.5 deg (C=1, CHCl3)
Storage Temperature: <0°C

SDS

Image Unavailable-AAH63214-MD

Fmoc-Lys(Dabcyl)-OH 95%

Supplier: Thermo Scientific Chemicals
Description: e-4-[4-(Dimethylamino)phenylazo]benzoyl-N^a-Fmoc-L-lysine, 95%

SDS Certificates

Image Unavailable-TCT2056-1G

2,3,4,6-Tetra-O-benzoyl-D-mannopyranose ≥93.0% (by HPLC)

Supplier: TCI America
Description: CAS Number: 113544-59-5
MDL Number: MFCD02683399
Molecular Formula: C34H28O10
Molecular Weight: 596.59
Purity/Analysis Method: >93.0% (HPLC)
Form: Crystal
Color: White
Melting point (°C): 182
Specific rotation [a]20/D: -78 deg (C=1, CHCl3)
Storage Temperature: <0°C

SDS

Image Unavailable-TCM1933-5G

Methyl-2,3,6-tri-O-benzoyl-ɑ-D-galactopyranoside ≥98.0% (by HPLC)

Supplier: TCI America
Description: CAS Number: 3601-36-3
MDL Number: MFCD06200842
Molecular Formula: C28H26O9
Molecular Weight: 506.51
Purity/Analysis Method: >98.0% (HPLC)
Form: Crystal
Melting point (°C): 143
Specific rotation [a]20/D: 123 deg (C=1, CHCl3)
Storage Temperature: 0-10°C

SDS Certificates

Product Image-89417-788

Anti-MYOZAP Rabbit Polyclonal Antibody

Catalog Number: (89417-788)
Supplier: Prosci
Description: MYOZAP Antibody: MYOZAP, also known as GRINL1A, is a 54 kDa highly conserved cardiac protein. It is strongly expressed in the heart and lung and is a novel component of intercalated disc. MYOZAP interacts with myosin phosphatase-RhoA interacting protein (MRIP) and acts as an activator of Rho-dependent SRF signaling. Knockdown study in zebrafish results in cardiomyopathy with severe dysfunction. The MYOZAP gene is part of a complex transcript unit that includes the gene for glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A (GRINL1A). Transcription of this gene occurs at an upstream promoter, with two different groups of alternatively spliced variants: Gup for GRINL1A upstream transcripts and Gcom for GRINL1A combined transcripts.
Image Unavailable-77978-311

TRC Benzoyl Peroxide

Catalog Number: (77978-311)
Supplier: LGC Standards
Description: TRC Benzoyl Peroxide

New Product


Image Unavailable-TCD4594-5G

(2R,3S,4R,5R)-5-((Benzoyloxy)methyl)-3-fluorotetrahydrofuran-2,4-diyl dibenzoate ≥98.0%

Supplier: TCI America
Description: CAS Number: 97614-43-2
MDL Number: MFCD00083339
Molecular Formula: C26H21FO7
Molecular Weight: 464.45
Purity/Analysis Method: >98.0% (GC)
Form: Crystal
Melting point (°C): 85

SDS

Product Image-10090-914

Anti-NQO1 Rabbit Polyclonal Antibody

Catalog Number: (10090-914)
Supplier: Proteintech
Description: NQO1, also named as DIA4, NMOR1, DTD and QR1, belongs to the NAD(P)H dehydrogenase (quinone) family. This enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. It is known to be involved in benzene metabolism. In human studies of ozone exposure, polymorphisms in oxidative stress genes (NQO1, GSTM1, GSTP1) modify respiratory symptoms, lung function, biomarkers and risk of asthma. This antibody recognizes all the three isoforms (26-27 kDa and 31 kDa) of NQO1 and the homo-dimer form (66-70 kDa) of NQO1.
Image Unavailable-77991-883

TRC 7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene

Catalog Number: (77991-883)
Supplier: LGC Standards
Description: TRC 7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene

New Product


Image Unavailable-77978-312

TRC N-(2-Benzoyl-4-chlorophenyl)-2-chloro-N-methylacetamide

Supplier: LGC Standards
Description: TRC N-(2-Benzoyl-4-chlorophenyl)-2-chloro-N-methylacetamide

New Product

Image Unavailable-10072-802

Human Recombinant PEDF (from E. coli)

Catalog Number: (10072-802)
Supplier: Prosci
Description: PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity (1) should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities implicate it as a potential therapeutic agent for the treatment of vasculature related neurodegenerative diseases such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF also has the potential to be useful in the treatment of various angiogenesis-related diseases including a number of cancers. Recombinant PEDF is a 44.5 kDa non-glycosylated protein containing 400 amino acid residues. (1) Notari, I. et al. J Biol Chem., Vol. 281, 38022-38037.
Image Unavailable-TCB3631-5G

N4-Benzoyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)cytidine ≥97.0% (by HPLC, total nitrogen)

Supplier: TCI America
Description: CAS Number: 69304-43-4
Molecular Formula: C28H43N3O7Si2
Molecular Weight: 589.84
Purity/Analysis Method: >97.0% (HPLC,N)
Form: Crystal
Melting point (°C): 101

SDS

Product Image-10750-028

Anti-GRIK4 Rabbit Polyclonal Antibody

Catalog Number: (10750-028)
Supplier: Prosci
Description: Grik4 Antibody: Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons. Five subunits can assemble to form kainate receptors (KARs): GluR5 (coded by Grik1), GluR6 (coded by Grik2), and GluR7 (coded by Grik3) are the low-affinity subunits, and KA1 and KA2 are the high-affinity subunits. In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Kainate receptors on GABA-containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling. KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of Grik4 with both schizophrenia and bipolar disorder.
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