You Searched For: CL-82198+(MMP-13+inhibitor)


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Catalog Number: (89158-280)
Supplier: Enzo Life Sciences
Description: Potent, dual site (ATP domain and substrate-binding domain) Src and Lck kinase inhibitor (IC50=44 and 88nM respectively). VEGFR2 IC50=0.32μM; c-fms IC50=30μM.


Catalog Number: (10403-608)
Supplier: Bioss
Description: May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.


Catalog Number: (10403-610)
Supplier: Bioss
Description: May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.


Supplier: VWR International
Description: These heat-transfer fluids provide superior thermal stability for high or low temperatures.

Product available on GSA Advantage®

Supplier: VWR International
Description: Clear liquid. Contains cyclohexene as a preservative.
Catalog Number: (CA80050-660)
Supplier: MilliporeSigma
Description: A potent, cell-permeable, and irreversible inhibitor of calpain II (k2=28,900 M-1s-1)

Catalog Number: (10403-618)
Supplier: Bioss
Description: May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.


Supplier: VWR
Description: A reversible inhibitor of cysteine proteases and serine proteases resembling trypsin
Catalog Number: (CAAAJ64615-LB0)
Supplier: Thermo Scientific Chemicals
Description: Yellow powder

Supplier: VWR International
Description: Ion chromatography & ion selective electrode (ISE) standard.

SDS

Catalog Number: (76101-226)
Supplier: Bioss
Description: Matrix Metalloproteinase 8 (MMP8) is also known as neutrophil collagenase and collagenase 2. MMP8 degrades fibrillar collagens types I, II, III, aggrecan, serpins and alpha 2 macroglobulin. All collagenases cleave fibrillar collagens at one specific site resulting in generation of N terminal three quarter and C terminal one quarter fragments, which then denature to gelatin at body temperature. The substrate specificity of collagenases is variable: MMP1 degrades type III collagen more efficiently than type I or type II collagen, whereas MMP8 is more potent in degrading type I collagen than type III or type II collagen. MMP13, in turn degrades type II collagen 6 fold more efficiently than type I and type II collagens and displays almost 50 fold stronger gelatinolytic activity than MMP1 and MMP8. MMP8 is very similar to MMP1, sharing 57 % amino acid identity. Most cell types do not produce MMP8. Until recently, it was thought that MMP8 was produced exclusively by neutrophils, but it has also been detected in other cell types including arthritic chondrocytes and gingival fibroblasts. The human MMP8 gene has the chromosomal location of 11q22.2-22.3. MMP8 is heavily glycosylated, and the zymogen has a mass of 85 Kd. The zymogen is quickly activated to the 64 Kd form, and this breaks down to a cascade of active forms.


Catalog Number: (89158-242)
Supplier: Enzo Life Sciences
Description: BML-277 is a highly selective inhibitor of Chk2 (IC50=15nM). It displays potent radioprotective activity and prevents apoptosis of human T cells subjected to ionizing radiation (EC50= 3-7.6µM). Useful tool for dissecting the role of Chk2 in cellular signaling.


Supplier: Enzo Life Sciences
Description: A potent and selective inhibitor of prolyl endopeptidase (PEP/PREP/POP, EC 3.4.21.26). Ki=0.35 nM for mouse brain enzyme. Inhibits the cleavage of arginine-vasopressin, gonadotropin-releasing hormone, and other peptides.

Catalog Number: (97062-754)
Supplier: VWR
Description: A competitive and reversible serine protease inhibitor of chymotrypsin, trypsin, kallikrein and plasmin

Catalog Number: (76078-906)
Supplier: Bioss
Description: May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.


Catalog Number: (BDH67009.400)
Supplier: VWR International
Description: 1,2,4-Trichlorobenzene ≥99.0%, HiPerSolv CHROMANORM® for HPLC, VWR Chemicals BDH®

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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