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Catalog Number: (CAPI89990)

Supplier: Thermo Scientific

Description: 35872619

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Catalog Number: (CAPIPA5-18730)

Supplier: Thermo Scientific

Description: This antibody is expected to recognize both reported isoforms (NP_004792. 1 and NP_620072. 1). It is predicted to react with canine, mouse and rat based on sequence homology. Neurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Two neurexin genes are among the largest known in human sequences and laminin G domains, and they interact with neurexophilins. Beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. The RefSeq Project has decided to create only a few representative transcript variants of the multitude that are possible.

Catalog Number: (CAPIPA5-18693)

Supplier: Thermo Scientific

Description: The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene.

Catalog Number: (CAPIPA5-18587)

Supplier: Thermo Scientific

Description: Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants.

Catalog Number: (CAPIPA5-18618)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with human and rat based on sequence homology. This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness.

Catalog Number: (CAPIPA5-18616)

Supplier: Thermo Scientific

Description: Huntington's disease , a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins , and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Catalog Number: (CAPIPA5-18611)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine, canine, mouse, porcine and rat based on sequence homology. This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.

Catalog Number: (CAPIPA5-18613)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with canine, mouse and rat based on sequence homology. Members of the ribonuclease III superfamily of double-stranded RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells processing in the nucleus .

Catalog Number: (CAPIPA5-18588)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with canine, mouse and rat based on sequence homology. TCFL5 is a new bHLH transcription factor that negatively regulates upstream transcription factor-dependent transcription.

Catalog Number: (CAPIPA5-18620)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with canine based on sequence homology. Farnesoid X-activated receptor (FXR), also known as the Bile acid receptor, is a member of the nuclear hormone receptor superfamily. FXR is involved in the regulation of bile acid metabolism. FXR forms a heterodimeric complex with the retinoic X receptor in the presence of a ligand. FXR is expressed primarily in liver and kidney.

Catalog Number: (CAPIPA5-18606)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with canine and mouse based on sequence homology. The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein plays a role in assembly of collagen fibrils and muscle regeneration. It interacts with several proteins involved in muscular dystrophy, including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the dystrophin-associated protein complex.

Catalog Number: (CAPIPA5-18599)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with canine based on sequence homology. SLC7A11 is a member of a heteromeric Na-independent anionic amino acid transport system highly specific for cystine and glutamate. In this system, designated system Xc, the anionic form of cystine is transported in exchange for glutamate.

Catalog Number: (CAPIPA5-18590)

Supplier: Thermo Scientific

Description: Humans lipodystrophy is characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mice carrying mutations in the fatty liver dystrophy gene have similar phenotypes. Through positional cloning, the mouse gene responsible for fatty liver dystrophy was isolated and designated Lpin1. The nuclear protein encoded by Lpin1 was named lipin. Lpin1 mRNA was expressed at high levels in adipose tissue and was induced during differentiation of preadipocytes. These results indicated that lipin is required for normal adipose tissue development and provided a candidate gene for human lipodystrophy. Through database searches, mouse and human EST and genomic sequences with similarities to Lpin1 were identified. These included two related mouse genes and three human homologs . Human LPIN1 gene has been mapped to 2p25. ; linkages of fat mass and serum leptin levels to this same region have been noted. Human LPIN2 and LPIN3 mapped to chromosomes 18p11 and 20q11-q12, respectively. The mouse genes encoding Lpin1, Lpin2, and Lpin3 mapped to chromosome 12, 17, and 2, respectively.

Catalog Number: (CAPIPA5-18885)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with mouse and rat based on sequence homology. This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.

Catalog Number: (CAPIPA5-18894)

Supplier: Thermo Scientific

Description: Recommended Dilutions: Western Blot: 1-3 ug/ml

Catalog Number: (CAPIPA5-18900)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine and mouse based on sequence homology.