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Catalog Number: (CAPIPA5-18305)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine, canine, porcine and rat based on sequence homology. This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.

Catalog Number: (CAPIPA5-18307)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine and porcine based on sequence homology. LIM proteins are defined by the possession of a highly conserved double zinc finger motif called the LIM domain.

Catalog Number: (CAPIPA5-18290)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with mouse and porcine based on sequence homology. This gene encodes a GTPase-activating protein that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.

Catalog Number: (CAPIPA5-18317)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with canine, mouse and rat based on sequence homology. This gene encodes a member of the low density lipoprotein receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- processing but the precise locations of the cleavage sites have not been determined.

Catalog Number: (CAPIPA5-18315)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with mouse based on sequence homology. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies . This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms.

Catalog Number: (CAPIPA5-18033)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with mouse based on sequence homology. This gene encodes a member of the interferon regulatory transcription factor family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. This protein is involved in palate formation.

Catalog Number: (CAPIPA5-18075)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology. This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex transcription coactivator-HAT complex, and the TFTC -containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.

Catalog Number: (CAPIPA5-18034)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology. This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6.

Catalog Number: (CAPIPA5-18072)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with mouse based on sequence homology. This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants.

Catalog Number: (CAPIPA5-18065)

Supplier: Thermo Scientific

Description: ESE-1 (Epithelium-Specific Ets) is a novel, highly tissue-restricted member of the ets transcription factor/oncogene family, which has features distinct from those of any other ets-related factor. ESE-1 binds with high affinity to and transactivates the ets binding site in the promoter of the keratinocyte terminal differentiation marker gene, SPRR2A. ESE-1 is a critical regulator of epithelial cell differentiation.

Catalog Number: (CAPIPA5-18052)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine and canine based on sequence homology. Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling.

Catalog Number: (CAPIPA5-18066)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology. Drosophila that have mutations in their mago nashi gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts.

Catalog Number: (CAPIPA5-18045)

Supplier: Thermo Scientific

Description: This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15. 5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4, escapes imprinting. This gene may play a role in malignancies and diseases that involve this region, and it is also involved in hematopoietic cell function. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Catalog Number: (CAPIPA5-12478)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine based on sequence homology. ENPP2 functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This protein stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. This protein is secreted and further processed to make the biologically active form.

Catalog Number: (CAPIPA5-18963)

Supplier: Thermo Scientific

Description: Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-betaB by IL-1/Toll receptors, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M. IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF-betaB activation. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cytokine IL-1 and LPS.

Catalog Number: (CAPIPA5-18942)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with canine, mouse, porcine and rat based on sequence homology. The exact function of this gene is not know. Studies in mice suggest that it may be involved in nucleic acid demethylation, and that its mRNA level is regulated by feeding and fasting. Genomewide association studies of type 2 diabetes indicate this gene as a diabetes susceptibility locus. Mutation in this gene has been associated with growth retardation, developmental delay, coarse facies, and early death.