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Catalog Number: (CAPIPA5-18830)

Supplier: Thermo Scientific

Description: Recommended Dilutions: Immunohistochemistry: 2-5µg/ml

Catalog Number: (CAPIPA5-18804)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with mouse and rat based on sequence homology.

Catalog Number: (CAPIPA5-18800)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with canine based on sequence homology. Phospholipase A2 catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets .

Catalog Number: (CAPIM808)

Supplier: Thermo Scientific

Description: The VEGF-A monoclonal antibody clone # 16F1 (Product # M808) has successfully been paired as the coating antibody in a sandwich ELISA with detection antibody P802B (biotinylated conjugate of Product # P802). Typical dilutions for sandwich ELISA include 1µg/ml for coating and 0.125-0.5µg/ml for detection. The VEGF gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis.

Catalog Number: (CAPIPA5-12374)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with rat based on sequence homology. NSE is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates.

Catalog Number: (CAPIPA5-15285)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with rat based on sequence homology. Phosphatidylinositol-4,5-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. TPIP5K2A is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. The protein is a member of the phosphatidylinositol-4-phosphate 5-kinase family.

Catalog Number: (CAPI113951)

Supplier: Thermo Scientific

Description: 32238807

Catalog Number: (CAPI111051)

Supplier: Thermo Scientific

Description: 32238807

Catalog Number: (CAPIPA5-13692)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with non-human primate based on sequence homology. The protein is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway.

Catalog Number: (CAPIPA5-13725)

Supplier: Thermo Scientific

Description: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK). The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).

Catalog Number: (CAPIPA5-13681)

Supplier: Thermo Scientific

Description: The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.

Catalog Number: (CAPIPA5-18314)

Supplier: Thermo Scientific

Description: This gene encodes a member of the ADAM protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene has two alternatively spliced transcripts: a shorter secreted form and a longer membrane-bound form. The shorter form is found to stimulate myogenesis.

Catalog Number: (CAPIPA5-18289)

Supplier: Thermo Scientific

Description: Recommended Dilutions: Western Blot: 1-3 ug/ml, Immunohistochemistry: 1-3µg/ml.

Catalog Number: (CAPIPA5-18300)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine, canine, feline and mouse based on sequence homology. This gene encodes a protein that is a member of the cysteine-aspartic acid protease family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.

Catalog Number: (CAPIPA5-18295)

Supplier: Thermo Scientific

Description: SAMSN1 is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM domains .

Catalog Number: (CAPIPA5-18297)

Supplier: Thermo Scientific

Description: This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED gene.