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Catalog Number: (CAPIPA5-18055)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with mouse, porcine and rat based on sequence homology. Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions.

Catalog Number: (CAPIPA5-15477)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine, chicken, mouse, non-human primate, rat and zebrafish based on sequence homology. YWHAB belongs to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for the gene. Both variants encode the same protein, however, they are differentially expressed in hematopoietic cells.

Catalog Number: (CAPIPA5-15009)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with mouse based on sequence homology. Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms.

Catalog Number: (CAPIPA5-15028)

Supplier: Thermo Scientific

Description: MERTK is a member of the MER/AXL/TYRO3 receptor kinase family and a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in MERTK gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).

Catalog Number: (CAPIPA5-18412)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies . This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene.

Catalog Number: (CAPIPA5-18415)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with mouse and rat based on sequence homology. Bone morphogenetic proteins are members of the transforming growth factor-beta superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.

Catalog Number: (CAPIPA5-18419)

Supplier: Thermo Scientific

Description: The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae . Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin family of proteins which are localized to the Golgi. Its encoded protein has been postulated to play a role in nuclear transport and Golgi apparatus localization. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Catalog Number: (CAPIPA5-18394)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology. Glutathione S-transferases are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.

Catalog Number: (CAPIPA5-18414)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine, canine, human and porcine based on sequence homology. The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 .

Catalog Number: (CAPIPA5-18373)

Supplier: Thermo Scientific

Description: The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency . AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Two transcript variants encoding the same protein have been identified for this gene.

Catalog Number: (CAPIPA5-18382)

Supplier: Thermo Scientific

Description: Dog neutrophil gelatinase-associated lipocalin (NGAL; also called lipocalin 2 or siderocalin) may, by analogy with its homologues in other mammalian species, be released from activated neutrophils in inflammation or infection, from certain epithelial cancers, and more dramatically from renal tubular cells in response to ischemic or nephrotoxic injury.

Catalog Number: (CAPIPA5-14368)

Supplier: Thermo Scientific

Description: ARSB belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targetted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B.

Catalog Number: (CAPIPA5-14394)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine and rat based on sequence homology. GDF6 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules. This protein is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this protein result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation.

Catalog Number: (CAPIPA5-14372)

Supplier: Thermo Scientific

Description: CD31 is a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions.

Catalog Number: (CAPIPA5-18875)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine and canine based on sequence homology. The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13. 1.

Catalog Number: (CAPIPA5-18946)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine, human and rat based on sequence homology.