You Searched For: STEMCELL Technologies

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG2b, antibody against human, chimpanzee, CD45RA, PE-conjugated.

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Catalog Number: (MSPP-100-1461)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal antibody against human TNF-alpha, PF647P-conjugated.

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Catalog Number: (MSPP-60089)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG2a antibody against human, rhesus, cynomolgus CD184 (CXCR4), unconjugated.

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Catalog Number: (MSPP-60161)

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2b antibody against mouse CD16/CD32, unconjugated.

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Catalog Number: (MSPP-100-1621)

Supplier: STEMCELL Technologies

Description: Rat monoclonal antibody against mouse IL-4, unconjugated.

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Catalog Number: (MSPP-60076)

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2a, kappa isotype control antibody, unconjugated.

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Catalog Number: (MSPP-100-1597)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal antibody against mouse CD45.2, FITC-conjugated.

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Catalog Number: (MSPP-07427)

Supplier: STEMCELL Technologies

Description: For digestion of native collagen fibrils.

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Catalog Number: (MSPP-100-1608)

Supplier: STEMCELL Technologies

Description: Rat monoclonal antibody against mouse CD3, PerCP-Cy5.5-conjugated.

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Catalog Number: (MSPP-60071)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG2a, kappa isotype control antibody, unconjugated.

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Catalog Number: (MSPP-02014)

Supplier: STEMCELL Technologies

Description: For detection and measurement of human interleukin 12 (p70) subunit.

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Supplier: STEMCELL Technologies

Description: For inhibition of trypsin activity.

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Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1, antibody against human, chimpanzee CD4, FITC-conjugated.

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Supplier: STEMCELL Technologies

Description: Interleukin 21 (IL-21) is a pleiotropic cytokine that is composed of four α-helical bundles and primarily produced by natural killer T (NKT) cells, T follicular helper (Tfh) cells, and Th17 cells (Spolski and Leonard 2008). IL-21 signals via receptor heterodimerization of IL-21 receptor and IL-2 receptor subunit gamma (IL-2RG or CD132), both of which have a common gamma-chain subunit and activate the JAK/STAT, MAPK, and PI3K pathways (Parrish-Novak <i>et al.</i>; Ozaki <i>et al.</i> 2000; Spolski and Leonard 2014). IL-21 has been shown to have a critical role in regulating immunoglobulin production and differentiation of the pro-inflammatory Th17 population of cells (Ozaki <i>et al.</i> 2002; Nurieva <i>et al.</i>). Additionally, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection (Elsaesser <i>et al.</i>). IL-21 signaling was also found critical for the development of type 1 diabetes in non-obese diabetic (NOD) mice (Sutherland <i>et al.</i>) and control of T cell autoimmunity by regulatory B cells (Yoshizaki <i>et al.</i>).

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Supplier: STEMCELL Technologies

Description: Interleukin 10 (IL-10) is the founding member of the IL-10 family of class II cytokines. All of the IL-10 cytokine family members have a four-helix bundle consisting of α-helical folds. Upon binding to its receptor, IL-10 activates signaling through JAK1 and STAT3. It is produced by dendritic cells, macrophages, and CD4+ T cells, as well as mast cells, NK cells, neutrophils, and B cells, under specific stimulating conditions (Saraiva and O'Garra). IL-10 can inhibit the expression of pro-inflammatory cytokines and promote healing processes, and is important for the function of regulatory T cells. IL-10 also enhances B cell proliferation, immunoglobulin secretion, and class II MHC expression, while IL-10 produced by macrophages inhibits activation of neighboring macrophages, thus allowing a level of self-regulation (Ouyang <i>et al.</i>).

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Supplier: STEMCELL Technologies

Description: Interleukin 6 (IL-6) is a pleiotropic growth factor with the wide range of biological activities in immune regulation, hematopoiesis, and oncogenesis. IL-6 is produced by a variety of cell types including T cells, B cells, monocytes and macrophages, fibroblasts, hepatocytes, vascular endothelial cells, and various tumor cell lines. On its own or in combination with other factors such as IL-2 and interferon-γ, IL-6 stimulates the proliferation of B cells, T cells, and hybridoma cells (Hirano <i>et al.</i>; Mihara <i>et al.</i>; Tanaka et al). In combination with cytokines such as IL-3, GM-CSF and SCF, IL-6 has been shown to promote hematopoietic progenitor cell proliferation and differentiation <i>in vitro</i>. IL-6 signals through a cell surface type I cytokine receptor complex consisting of the ligand-binding IL-6α (CD126) and the signal-transducing gp130 subunits. The binding of IL-6 to its receptor system includes activation of JAK/STAT signaling pathway (Mihara <i>et al.</i>; Peters <i>et al.</i>; Tanaka <i>et al.</i>).

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