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Catalog Number: (89154-590)
Supplier: Enzo Life Sciences
Description: Host: Mouse, Isotype: IgG2a


Supplier: Enzo Life Sciences
Description: Modification of proteins by addition of K63-linked polyubiquitin chains is implicated in a variety of cellular events, including DNA repair, signal transduction and receptor endocytosis.

Supplier: Enzo Life Sciences
Description: Host: Rabbit

Catalog Number: (89162-156)
Supplier: Enzo Life Sciences
Description: Host: Mouse, Isotype: IgG1


Supplier: Enzo Life Sciences
Description: Host: Rabbit

Supplier: Enzo Life Sciences
Description: Host: Rabbit

Catalog Number: (89156-306)
Supplier: Enzo Life Sciences
Description: The ICCB Known Bioactives Library is an important product for use in chemical genetics and drug discovery.


Catalog Number: (89153-964)
Supplier: Enzo Life Sciences
Description: Host: Mouse, Isotype: IgG1


Catalog Number: (89153-930)
Supplier: Enzo Life Sciences
Description: Host: Mouse, Isotype: IgG


Catalog Number: (89153-932)
Supplier: Enzo Life Sciences
Description: Host: Mouse, Isotype: IgG2b


Catalog Number: (89163-220)
Supplier: Enzo Life Sciences
Description: Host: Rabbit


Catalog Number: (89163-198)
Supplier: Enzo Life Sciences
Description: Host: Rabbit


Catalog Number: (89163-226)
Supplier: Enzo Life Sciences
Description: Host: Rabbit


Supplier: Enzo Life Sciences
Description: The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

Catalog Number: (89166-078)
Supplier: Enzo Life Sciences
Description: Host: Mouse, Isotype: IgG1


Catalog Number: (89160-054)
Supplier: Enzo Life Sciences
Description: The rate limiting enzyme in heme catabolism, heme oxygenase, was first described in 1968 and was thought to be a species of cytochrome P450. However, subsequent work showed the enzyme to be a protein distinct from the P450 family and capable of catalysing the degradation of heme to biliverdin and iron, with the concomitant release of carbon monoxide. This enzyme activity is highly conserved throughout the Animal Kingdom and has been identified in algae and plants as well as in all higher species. Heme oxygenase-1 (HO-1) was first purified to homogeneity from rat liver and pig spleen and shown to have a molecular weight of 32kDa. Increased expression of HO-1 can be induced by a large number of structurally unrelated pharmacological and other agents, including cytokines and oxidants, as well as by heat shock and other forms of cellular stress. Baseline levels of HO-1 expression are high in certain tissues, including spleen and liver, but enriched enzyme preparations are recommended for experimental analysis. Recent data have demonstrated a cytoprotective role for HO-1, preventing cell death by modulating intracellular iron levels.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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