You Searched For: Diagnostic Biosystems

Supplier: Diagnostic Biosystems

Description: This antibody reacts specifically with Sialyl Lewis A and recognizes an epitope being designated CA 19-9. It does not cross-react with Lewis A and Lewis B. CA 19-9 has been shown to be useful marker in the diagnosis and management of gastrointestinal cancers.

Supplier: Diagnostic Biosystems

Description: This antibody is specific to 50 kDa cytokeratin protein designated cytokeratin 14. Cytokeratin 14 belongs to the type A (acidic) subfamily of low molecular weight cytokeratins and exists in combination with cytokeratin 15. This antibody can be used to distinguish stratified epithelial cells from simple epithelial cells.

Catalog Number: (CA76633-558)

Supplier: Diagnostic Biosystems

Description: 31472488

Supplier: Diagnostic Biosystems

Description: The BCL-2 product is considered to act as an inhibitor of apoptosis. BCL-2 expression is inhibited in germinal centers where apoptosis forms part of the B cell production pathway. Reactive follicles show no staining for BCL-2, whereas the cells in neoplastic follicles exhibit membrane staining. BCL-2 α oncoprotein has been shown to inhibit apoptosis.

Supplier: Diagnostic Biosystems

Description: PCNA is essential for cellular DNA synthesis. This antibody reacts with proliferating cells in a wide range of normal tissues. The significance of PCNA immunoreactivity in tumors in not fully established. However, in non-Hodgkin lymphoma a linear relation between Ki-67 and PCNA staining has been demostrated.

Supplier: Diagnostic Biosystems

Description: Alpha Fetoprotein (AFP) is a single chain glycoprotein of 70 kDa that is normally expressed in the fetal liver, gastrointestinal tract and yolk sac. This antibody recognizes an epitope of α-fetoprotein present in human and several other species.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with human prostate specific antigen.

Supplier: Diagnostic Biosystems

Description: This antibody is specific to 450 kDa (non-reduced) and 170 to 180 kD (reduced) form of thrombospondin. Thrombospondin is a protein from platelet α granules. It is secreted at sites of platelet activation and aggregation and is involved in the differentiation of leukocytes, fibroblasts, smooth muscle and endothelial cells.

Supplier: Diagnostic Biosystems

Description: Cytokeratin 15 is a type I cytokeratin without a defined type II partner. Cytokeratin 15 is expressed primarily in the basal keratinocytes of stratified tissues, including the fetal epidermis and fetal nail.

Catalog Number: (CA76634-882)

Supplier: Diagnostic Biosystems

Description: Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S transition. Amplification or overexpression of Cyclin D1 plays a pivotal role in the development of various human cancers including breast cancer, colon cancer, melanoma, prostate cancer and lymphoma. It is useful to differentiate mantle cell lymphoma from small cleaved cell lymphoma. Rabbit monoclonal antibodies to Cyclin D1 showed the highest sensitivity to detect this antigen in formalin fixed paraffin embedded tissue as compared to several other clones.

Supplier: Diagnostic Biosystems

Description: SOX-10, a member of the sex-determining region Y-related HMG-box family, is a transcription factor that is expressed in pre-migratory and migrating neural crest cells. Following migration it remains expressed in cells destined for glial, schwannian, and melanocytic differentiation. SOX10 is widely expressed in normal human tissues including melanocytes and breast tissue. SOX10 is also an important marker in malignant tumors such as melanoma, and breast carcinomas of basal-like and triple negative type, gliomas, and benign tumors such as schwannomas. More importantly, SOX10 has been shown to be expressed in 97 to 100% of desmoplastic and spindle cell melanomas and has also been shown to be expressed in 100% of nevi. Spindle cell and desmoplastic melanomas are rare variants of invasive cutaneous melanoma, with an annual incidence rate of approximately 2 per 100,000. The majority of oligodendrogliomas and a large percentage of astrocytomas and poorly differentiated glioblastomas have also been shown to express SOX10.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with human fibronectin in liver, tonsil, skin and kidney. Traces of contaminating antibodies have been removed by solid-phase adsorption. Only the fibronectin arch was observed in crossed immunoelectrophoresis.

Catalog Number: (CA76634-468)

Supplier: Diagnostic Biosystems

Description: This antibody is specific against an epitope located on the β-chain (i.e., in S-100a and S-100b) but not on the α-chain of S-100 (i.e., in S-100a and S-100ao). This antibody can be used to localize S-100a and S-100b in various tissue sections.

Catalog Number: (CA76634-500)

Supplier: Diagnostic Biosystems

Description: This antibody is specific to 21 kDa protein known as TIMP-2. TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family. TIMP are of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (MMP-2) and active form of 92 kDa type IV collagenase (MMP-9). TIMP inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.

Catalog Number: (CA76634-530)

Supplier: Diagnostic Biosystems

Description: Podoplanin is a 38 kDa membrane mucoprotein originally detected on the surface of rat podocytes .The antibody against podoplanin (D2-40) reacts to a 40 kDA sialogylcoprotein found on lymphatic endothelium, fetal testis, and on the surface of testicular germ cell tumors. Podoplanin can be used to assist pathologists in identifying lymphatic endothelium to determine lymphatic invasion and also can be used to help differentiate mesothelioma from adenocarcinoma.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Mast cells contain a number of preformed chemicals mediators such as histamine, chymase, carboxypeptidase, and proteolytic tryptase. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation.