You Searched For: Diagnostic Biosystems

Catalog Number: (CA76634-282)

Supplier: Diagnostic Biosystems

Description: This antibody recognizes a single chain glycoprotein of 105/120kDa, identified as CD30/Ki-1. Its epitope is located between aa112-412. CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. In Hodgkin's disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).

Supplier: Diagnostic Biosystems

Description: Recognizes a protein of 55 kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin s disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.

Catalog Number: (CA76634-292)

Supplier: Diagnostic Biosystems

Description: This antibody is specific to CD74. This antibody can be used for the identification of B cell lymphomas and leukemias. It also stains activated neoplastic cells in T cell lymphomas and Sternberg-Reed cells.

Supplier: Diagnostic Biosystems

Description: The BCL6 gene encodes a 706 amino acid nuclear protein of the Kruppeltype zinc finger protein. It is rearranged in about 30% of diffuse large B-cell lymphomas, and is expressed predominantly in normal germinal centre B cells and related lymphomas. The antibody is a useful aid for classification of follicular lymphomas, diffuse large B-cell lymphomas, Burkitt's lymphomas, and nodular, lymphocyte-predominance Hodgkin's lymphoma. The BCL6 antibody, together with BCL2 antibody, is also a useful aid in classification of mantle cell lymphomas, and nodular, lymphocytepredominance Hodgkin's lymphoma. BCL6 protein is not expressed in BCLL, hairy cell leukemia, mantle cell and marginal-zone derived lymphomas

Catalog Number: (CA76634-278)

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 180 to 185kDa protein, identified as isoform of leukocyte common antigen (CD45RO) (4th Leucocyte Typing Workshop: Code No. N31). The epitope recognized by this antibody is sensitive to neuraminidase digestion.

Supplier: Diagnostic Biosystems

Description: This antibody recognizes a single chain glycoprotein of 105/120 kDa, identified as CD30/Ki-1. Its epitope is located between aa112-412. CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120 kDa glycoprotein. In Hodgkin's disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).

Catalog Number: (CA76634-514)

Supplier: Diagnostic Biosystems

Description: Recognizes a protein of 48 kDa, which is identified as Adipophilin. It belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases.

Catalog Number: (CA76634-558)

Supplier: Diagnostic Biosystems

Description: PTEN gene is a tumor suppressor gene that maps to chromosome 10q23. PTEN, a novel tumor suppressor, functions as a regulator of both cell cycle progression and apoptosis ). Potentially, mutation and deletion of PTEN gene may result in a new signal transduction pathway related to human malignant tumors. Studies have demonstrated a reduction of PTEN expression in advanced breast cancers.

Supplier: Diagnostic Biosystems

Description: The clone F7.2.38 is specific for the non-glycosylated epsilon chain of the human CD3 molecule. Clone F7.2.38 recognizes T cells in the thymus, bone marrow, peripheral lymphoid tissue and blood and is a pan T cell marker. The CD3 molecule consists of five different polypeptide chains with molecular weights ranging from 16 to 28 kD. The CD3 antigen is first detected in early thymocytes and its appearance probably represents one of the earliest signs of commitment to the T cell lineage.

Catalog Number: (CA76634-494)

Supplier: Diagnostic Biosystems

Description: This antibody is specific to a 48 kDa protein, which is identified as cytokeratin 16. Cytokeratin 16 is expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region. High concordance was found between the carcinomas immunostaining with the basal cell and the hyperproliferation-related keratins.

Catalog Number: (CA76634-258)

Supplier: Diagnostic Biosystems

Description: This antibody is specific to α-smooth muscle isoform of actin. It reacts with smooth muscle cells of vessels and different parenchymes. This antibody does not cross-react with β and γ-cytoplasmic, α-sarcomeric and α-myocardial actin isoforms.

Catalog Number: (CA76634-264)

Supplier: Diagnostic Biosystems

Description: This antibody reacts with desmin protein of 53 kDa. Both striated as well as smooth muscle cells stain well with this antibody. The antibody shows a broad interspecific cross-reactivity, reacting with human.

Catalog Number: (CA76634-260)

Supplier: Diagnostic Biosystems

Description: This antibody is specific to a 33 kDa polypeptide present on the majority of B cells in peripheral blood and lymphoid tissue. No reactivity with other hematopoietic cells has been observed.

Catalog Number: (CA76634-622)

Supplier: Diagnostic Biosystems

Description: This antibody reacts with chains of human IgG. Nonspecific antibodies have been removed by solid-phase adsorption.

Catalog Number: (CA76634-618)

Supplier: Diagnostic Biosystems

Description: This antibody does not show any cross-reactivity with kappa light chain. It stains B cell follicles in human lymphoid tissues. The mantle zone shows a mosaic pattern of labeling while the germinal centers show a coarse meshwork pattern of staining.

Supplier: Diagnostic Biosystems

Description: The catenins are structurally related cytoplasmic proteins which have been classified as alpha (α), beta (β), and gamma (γ), these proteins can bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. β-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule.