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Avantor Single-Use Tank Liners, Medical Grade, Avantor Fluid Handling

Supplier: AVANTOR FLUID HANDLING, LLC
Description: These tank liners are single-use bags with an open top, designed to fit in cylindrical vessels.

Product Image-52202-509

VWR® Signature™ High-Performance Horizontal Air Flow Ovens

Supplier: VWR International
Description: Horizontal airflow is created using a turbo blower that re-circulates air over the heating element, providing fast heat-up and recovery times, and ensuring a more rapid and efficient rate of drying.

Small Business Enterprise Irregular Voltage Minority or Woman-Owned Business Enterprise Product available on GSA Advantage®

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Avantor 3D Mixing Bags

Supplier: Avantor Fluid Handling
Description: The Magnetic Mixing bags offer a sterile, single use mixing container designed to maximize mixing performance while minimizing disruptive shear.

Image Unavailable-10451-500

Anti-XPC Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (10451-500)
Supplier: Bioss
Description: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
Image Unavailable-10451-504

Anti-XPC Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (10451-504)
Supplier: Bioss
Description: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
Product Image-10830-696

Avantor Sterile Polycarbonate Single-Use Bottle Assemblies, Avantor Fluid Handling

Supplier: VWR International
Description: Sterile polycarbonate containers with weldable tubing provide the maximum amount of flexibility and reliability.

Certificates

Product Image-VWRSSNL1566

VWR® Atlas Slot-Mounted Shelving, Single-Sided

Supplier: VWR International
Description: Slot-mounted shelving for single-sided applications.

Product available on GSA Advantage®

Product Image-470117-616

Neulog Chemistry Bundle

Catalog Number: (470117-616)
Supplier: Avantor
Description: A set of five NeuLog sensors that are great for use in chemistry classrooms.
Product Image-53508-386

Accessories and Replacement Parts for VWR® Microdispensers

Supplier: VWR International
Description: VWR® pipette tips and capillaries are for use with VWR® microdispensers (see <B>53506-100</B> series).

Product available on GSA Advantage®

Product Image-470117-620

Neulog Environmental Bundle

Catalog Number: (470117-620)
Supplier: Avantor
Description: A set of six NeuLog sensors that are great for use in environmental science classrooms.
Image Unavailable-76117-072

Anti-p95 NBS1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76117-072)
Supplier: Bioss
Description: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
Image Unavailable-10430-766

Anti-NBN Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10430-766)
Supplier: Bioss
Description: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
Product Image-470117-612

Neulog Physics Bundle

Catalog Number: (470117-612)
Supplier: Avantor
Description: A set of nine NeuLog sensors that are great for use in a physics class.
Product Image-75840-760

Avantor OmniTop Assemblies, Pre-Sterilized Single-Use Sample Tubes®, Avantor Fluid Handling

Supplier: Avantor Fluid Handling
Description: OmniTop Sample Tubes® are a convenient device that can be used to obtain fluid samples. Each single-use OmniTop tube comes with a pre-attached 0.2 µm vent filter and 18" of tubing (C-Flex®, TYGON®, silicone or PharMed®).

Certificates

Image Unavailable-76117-074

Anti-p95 NBS1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76117-074)
Supplier: Bioss
Description: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
Product Image-470117-618

Neulog Physical Science Bundle

Catalog Number: (470117-618)
Supplier: Avantor
Description: A set of eight NeuLog sensors that are great for use in a physical science class.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email CMD_NA@vwr.com or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:

  • issued document with your organization's Federal Tax ID Number
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