You Searched For: Topotecan+hydrochloride


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Supplier: Enzo Life Sciences
Description: Potent antitumor agent. Inhibitor of DNA-topoisomerase. Analog of (S)-(+)-camptothecin. Used in chemotherapy of several different cancers.

Catalog Number: (77437-636)
Supplier: Bioss
Description: An ABC transporter. Allows efflux of Hoechst dye, a property that has been used to separate bone marrow side population cells, which express BCRP/ABCG2. Appears to play a major role in the multidrug resistance phenotype of a specific MCF-7 breast cancer cell line. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.Breast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone.

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Catalog Number: (89367-424)
Supplier: Genetex
Description: MRP4 transports cyclic nucleotides and anti-retroviral compounds and may be an organic anion pump relevant to cellular detoxification. It is widely expressed, with particularly high levels in prostate, but is barely detectable in liver. It belongs to the ATP binding cassette (ABC) transporter family. MRP4 confers resistance to topotecan and acts as a double agent in protecting the brain from chemotherapy.


Catalog Number: (77436-882)
Supplier: Bioss
Description: An ABC transporter. Allows efflux of Hoechst dye, a property that has been used to separate bone marrow side population cells, which express BCRP/ABCG2. Appears to play a major role in the multidrug resistance phenotype of a specific MCF-7 breast cancer cell line. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.Breast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone.

New Product


Catalog Number: (CA80055-528)
Supplier: MilliporeSigma
Description: Trimethylated xanthine that acts as a potent central nervous system stimulant. At higher doses, produces tachycardia and interferes with the uptake and storage of Ca2+ by sarcoplasmic reticulum in skeletal muscle. Prevents apoptosis and cell cycle effects induced by camptothecin (80055-998) and topotecan in HL-60 cells. Heavy metals: <=10ppm.

Supplier: AVANTOR PERFORMANCE MATERIAL LLC
Description: L(+)-Arginine hydrochloride, 98.5-101.5% (dried basis), Usp grade, FCC, Multi-compendial, Synonyms: (S)-(+)-Arginine hydrochloride, L-Arginine, hydrochloride, L-(+)-Arginine Monohydrochloride, L-Arginine monohydrochloride, H-L-Arg-OH.HCl, H-Arg-OH.HCl, size: 12kg
Supplier: AVANTOR PERFORMANCE MATERIAL LLC
Description: Guanidinium hydrochloride 99.5-101.0%, GenAR* for biotechnology, Synonyms: Guanidinium chloride, Guanidine hydrochloride, Guanidine chloride, Guanadine hydrochloride, Packaging: Mall Polystormor Poly/Plastic Bottle, Size: 500g

Supplier: AVANTOR PERFORMANCE MATERIAL LLC
Description: Clear, colorless liquid. Suitable for use in biotechnology. GMP manufactured product.

Supplier: VWR
Description: Suited for purification of nucleic acids or polypeptides from cell sources and inhibition of both RNase and protease activity.
Catalog Number: (97062-038)
Supplier: VWR
Description: A protease inhibitor of arginine-selective enzymes like trypsin, kallikrein and thrombin.

Catalog Number: (97063-766)
Supplier: VWR

Supplier: AVANTOR PERFORMANCE MATERIAL LLC
Description: L-Arginine hydrochloride 98.5-101.0% USP, Multi-Compendial, meets analytical specification of ChP, BP, JP, Ph. Eur., Macron Fine Chemicals™

Supplier: VWR International
Description: Meets reagent specifications for testing USP/NF monographs.
Catalog Number: (97061-350)
Supplier: VWR
Description: Suited for purification of nucleic acids or polypeptides from cell sources and inhibition of both RNase and protease activity.

Supplier: AVANTOR PERFORMANCE MATERIAL LLC
Description: Tris Hydrochloride 50Kg
Catalog Number: (CAJT2067-9)
Supplier: AVANTOR PERFORMANCE MATERIAL LLC

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