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Supplier: TCI America
Description: CAS Number: 7440-05-3
Molecular Formula: Pd
Molecular Weight: 106.42
Form: Crystals
Color: Black
Supplier: AVANTOR PERFORMANCE MATERIAL LLC
Description: Powder. Lot analysis on label.
Catalog Number: (10752-260)
Supplier: Prosci
Description: ORAI3 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry t hrough Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE; these may represent post-translationally modified ORAI 3.


Catalog Number: (10752-258)
Supplier: Prosci
Description: ORAI3 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry t hrough Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE; these may represent post-translationally modified ORAI 3.


Catalog Number: (10749-952)
Supplier: Prosci
Description: ORAI1 Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor.


Catalog Number: (10486-432)
Supplier: Bioss
Description: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.


Catalog Number: (10486-430)
Supplier: Bioss
Description: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.


Supplier: VWR International
Description: These performance glass door refrigerators offer top-quality features in laboratory cold storage with advanced data logging and superior temperature control.

Environmentally Preferable

Supplier: VWR International
Description: These are the cleanest and most durable coveralls available within the VWR® Protection line. Manufactured from a specially formulated breathable microporous fabric, these garments are distinguished by their exceptional comfort benefits and superior barrier protection capabilities.

Catalog Number: (CA1.09196.0025)
Supplier: MilliporeSigma
Description: Cas Number 1324-76-1, Indicator, Cas Number 1324-76-1

Catalog Number: (10748-674)
Supplier: Prosci
Description: STIM2 Antibody: In T lymphocytes, the sole pathway for Ca++ entry following antigen-receptor binding is through store-operated Ca++-release-activated Ca++ (CRAC) channels. These channels are made up of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca++ sensor and activates the CRAC channels, migrating to the plasma membrane from endoplasmic reticulum (ER)-like sites which act as the Ca++ store. A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca++ entry, and can form complexes with STIM1, suggesting they may play a coordinated role in controlling Ca++ entry. At least three isoforms of STIM2 are known to exist. This STIM2 antibody is predicted to have no cross-reactivity to STIM1.


Supplier: TCI America
Description: 4-Bromocarbazole, Purity: 98.0% CAS 3652-89-9, Cas no. 3652-89-9, Molecular formula: C12H8BrN, Form: Crystal- Powder, Colour: White - Slightly pale yellow green, Size: 1G
Catalog Number: (470301-298)
Supplier: Ward's Science
Description: CAS Number: 860-22-0
Formula Weight: 466.36
Formula: C16H8N2Na2O8S2
Solubility: Water and Alcohol
Synonyms: Acid Blue 74, C.I. No. 73015
Shelf Life (months): 36
Storage: Green

SDS


Supplier: Ward's Science
Description: CAS Number: 7782-42-5
Formula Weight: 12.01
Formula: C
Density (g/mL): 2.26
Freezing Point (°C): Sublimes
Synonyms: Carbon, Black Lead
Shelf Life (months): 36
Storage: Green

SDS

Supplier: TCI America
Description: CAS Number: 7440-05-3
Molecular Formula: Pd
Molecular Weight: 106.42
Form: Powder
Color: Black
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