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Image Unavailable-10423-660

Anti-ITGAV Polyclonal Antibody (Cy7®)

Catalog Number: (10423-660)
Supplier: Bioss
Description: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha-v beta-6 is upregulated in cancers and during tissue remodelling but is absent from resting adult tissues. Integrin alpha-v beta-6 promotes invasion and correlates with poor survival and therefore makes a promising therapeutic target.
Image Unavailable-10486-214

Anti-POLB Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10486-214)
Supplier: Bioss
Description: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.
Image Unavailable-10487-100

Anti-PSMB3 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10487-100)
Supplier: Bioss
Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring shaped 20S core structure. The core structure is composed of 4 rings of 28 non identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin dependent process in a non lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.
Image Unavailable-10487-126

Anti-PSMB6 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10487-126)
Supplier: Bioss
Description: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the peptidyl glutamyl-like activity. May catalyze basal processing of intracellular antigens.
Image Unavailable-10471-078

Anti-TBCD Rabbit Polyclonal Antibody

Catalog Number: (10471-078)
Supplier: Bioss
Description: Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Acts as a GTPase-activating protein (GAP) for ARL2. Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane.
Image Unavailable-75843-666

Anti-TCRB Armenian Hamster Monoclonal Antibody (PerCP (Peridinin-Chlorophyll Protein Complex)-Cy5.5®) [clone: H57-597]

Catalog Number: (75843-666)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The H57-597 monoclonal antibody is specific for the beta chain of the mouse T cell Receptor (TCR). The crosslinking induces activation and proliferation of T cells, as a plate-bound or a soluble H57-597, or the plate-bound antibody can induce apoptosis, based on assay conditions. The beta chain of the TCR can combine with the alpha chain of the receptor to produce the alpha-beta TCR, which is expressed by the NKT cells, by the NK1.1+ thymocytes and most of the T cells. The beta chain does not react with the gamma-delta TCR-bearing cells, expressed by a small number of T cells. This antibody can be used as a phenotypic marker for the TCR beta expressing cells or for the functional purpose of TCR-mediated cell activation or apoptosis.
Image Unavailable-75950-160

Anti-CGB Mouse Monoclonal Antibody (CF640R) [clone: hCGb/459]

Supplier: Biotium
Description: HCG-beta, Monoclonal antibody, Clone: hCGb/459, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: CF640R, Immunogen: Recombinant hCG beta protein (HCGb/54 and HCGb/459), Synonyms: CG-beta; CGB3; CGB5; CGB7; CGB8, Application: Immunofluorescence, Size: 100uL

Image Unavailable-75951-826

Anti-CGB Mouse Monoclonal Antibody (CF647) [clone: HCGb/54 HCGb/459]

Supplier: Biotium
Description: HCG-beta, Monoclonal antibody, Clone: HCGb/54+ HCGb/459, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: CF647, Immunogen: Recombinant hCG beta protein (HCGb/54 and HCGb/459), Synonyms: CG-beta; CGB3; CGB5; CGB7; CGB8, Application: IHC, Size: 100uL

Image Unavailable-75952-538

Anti-CGB Mouse Monoclonal Antibody (CF660R) [clone: HCGb/211]

Supplier: Biotium
Description: This MAb reacts with a protein of 22 kDa, identified as β sub-unit of HCG. It does not cross react with the α sub-unit. HCG is a glycoprotein, which is secreted in large quantities by normal trophoblasts. It is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG is composed of two non-identical, non-covalently linked polypeptide chains designated as the alpha and beta subunits. The beta subunit is identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH). hCG MAb detects cells and tumors of trophoblastic origin such as choriocarcinoma. Large cell carcinoma and adenocarcinoma of the lung demonstrate anti-hCG positivity in 90% and 60% of cases respectively. 20% of lung squamous cell carcinomas are positive. hCG expression by non-trophoblastic tumors may indicate aggressive behavior.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®660R is a far-red fluorescent dye (Ex/Em 663/682 nm) with superior brightness and unrivaled photostability among spectrally similar dyes.

Product Image-10788-516

Rat Recombinant IL-1 B (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC
Description: Interleukin 1 beta (IL-1β) is a pro-inflammatory cytokine that is produced by monocytes, macrophages, and dendritic cells (DCs). IL-1β signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic Toll/IL-1 receptor (TIR) domain adapter. IL-1β and the independently regulated IL-1α protein have overlapping proinflammatory activities to induce adhesion molecule expression on epithelial cells, control fever induction, initiate rheumatoid arthritis, and promote septic shock.

Image Unavailable-75950-116

Anti-CGB Mouse Monoclonal Antibody (CF640R) [clone: HCGb/211]

Supplier: Biotium
Description: This MAb reacts with a protein of 22 kDa, identified as β sub-unit of HCG. It does not cross react with the α sub-unit. HCG is a glycoprotein, which is secreted in large quantities by normal trophoblasts. It is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG is composed of two non-identical, non-covalently linked polypeptide chains designated as the alpha and beta subunits. The beta subunit is identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH). hCG MAb detects cells and tumors of trophoblastic origin such as choriocarcinoma. Large cell carcinoma and adenocarcinoma of the lung demonstrate anti-hCG positivity in 90% and 60% of cases respectively. 20% of lung squamous cell carcinomas are positive. hCG expression by non-trophoblastic tumors may indicate aggressive behavior.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Product Image-10797-010

Recombinant Betalobulin (from HEK293 cells)

Catalog Number: (10797-010)
Supplier: Prosci
Description: ?2 microglobulin is also known as Beta-2-microglobulin (B2M), is a component of MHC class I molecules which belongs to the beta-2-microglobulin family. B2M is present on all nucleated cells (excludes red blood cells). B2M associates not only with the alpha chain of MHC class I molecules, but also with class I-like molecules such as CD1 and Qa. An additional function of B2M is association with the HFE protein, together regulating the expression of hepcidin in the liver which targets the iron transporter ferroportin on the cytoplasmic membrane of enterocytes and macrophages for degradation resulting in decreased iron uptake from food and iron release from recycled red blood cells respectively. Loss of this function causes iron excess and hemochromatosis. Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP).
Image Unavailable-TCF0185-1G

2-Fluoro-β-alanine hydrochloride ≥99.0% (by total nitrogen basis)

Catalog Number: (TCF0185-1G)
Supplier: TCI America
Description: CAS Number: 867-84-5
MDL Number: MFCD00060202
Molecular Formula: C3H6FNO2
Molecular Weight: 143.54
Purity/Analysis Method: >99.0% (N)
Form: Crystal

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Image Unavailable-TCM1482-5G

4-Methoxyphenyl-3-O-allyl-β-D-galactopyranoside ≥98.0% (by HPLC)

Catalog Number: (TCM1482-5G)
Supplier: TCI America
Description: CAS Number: 144985-19-3
MDL Number: MFCD06797127
Molecular Formula: C16H22O7
Molecular Weight: 326.35
Purity/Analysis Method: >98.0% (HPLC)
Form: Crystal
Melting point (°C): 143
Specific rotation [a]20/D: -10 deg (C=1, MeOH)
Storage Temperature: <0°C

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Product Image-77975-380

EDTA (Ethylenediamine tetraacetic acid) solution 0.526 mM (Versene 1:5000)

Catalog Number: (77975-380)
Supplier: FUJIFILM IRVINE SCIENTIFIC INC.
Description: <p>EDTA (Versene) Solution 0.526 mM (1:5000) is a chelating agent used to life some cell types from the culture vessel surface into suspension.</p>

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Product Image-97061-020

EDTA disodium salt dihydrate for biotechnology

Supplier: VWR
Description: A reversible metalloprotease inhibitor useful for chelating metal ions.

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