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Supplier: Enzo Life Sciences
Description: Inhibitor of PP1 and PP2A

Supplier: Enzo Life Sciences
Description: Inhibitor of PP1 and PP2A

Supplier: Enzo Life Sciences
Description: Inhibitor of PP1 and PP2A

Supplier: Enzo Life Sciences
Description: Inhibitor of PP1 and PP2A

Catalog Number: (ABCA_AB2897-200UL)
Supplier: Abcam
Description: Anti-Okadaic Acid Rabbit Polyclonal Antibody

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Catalog Number: (ABCA_AB82716-100UL)
Supplier: Abcam
Description: Anti-Okadaic Acid Mouse Monoclonal Antibody [clone: 70]

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Supplier: Enzo Life Sciences
Description: Cell permeable inhibitor of the 26S proteasome (MCP; multicatalytic proteinase complex) in HT4 cells. Causes accumulation of ubiquitinylated proteins in neuronal cells. Prevents the activation of NF-κB in response to TNF-α or okadaic acid through inhibition of IκBα degradation.

Catalog Number: (10092-672)
Supplier: Proteintech
Description: PPM1L(Protein phosphatase 1L) is also named as PP2CE.It belongs to the PP2C group of serine/threonine phosphatases, which are distinguished from other phosphatases by their structure, absolute requirement for Mg(2+) or Mn(2+), and insensitivity to okadaic acid. It has 4 isoforms produced by alternative splicing.This antibody is specific to PPM1L.


Catalog Number: (77439-764)
Supplier: Bioss
Description: PPM1D (Wip) is a serine/threonine phosphatase implicated in cell cycle control, spermatogenesis, and lymphoid cell function. The predicted 605-amino acid PPM1D protein contains 2 putative nuclear localization signals and 3 regions conserved in serine/threonine PP2C phosphatases, as well as characteristics of a type 2C phosphatase, including magnesium dependence and relative insensitivity to okadaic acid. PPM1D expression is induced in response to ionizing radiation in a p53-dependent manner. The accumulation of PPM1D mRNA following ionizing radiation is rapid and transient, and PPM1D protein is localized to the nucleus. PPM1D may contribute to growth inhibitory pathways activated in response to DNA damage in a p53-dependent manner. PPM1D inhibits phosphorylation of the p38 mitogen-activated (MAP)kinase protein. Through p38 MAPK, PPM1D modulates the CDKN2A tumor-suppressor locus. This gene is located in a chromosomal region known to be amplified in breast cancer, (located at 17q22-q23), is amplified in human breast tumor cell lines and in approximately 11% of primary breast tumors, and appears to lead to cell transformation by abrogating p53 tumor suppressor activity. Inactivation of the p38 MAPK through PPM1D overexpression resulting from PPM1D amplification may contributes to the development of human cancers by suppressing p53 activation. PPM1D null mice have increased susceptibility to pathogens and reduced male fertility and longevity.
Function : Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins.
Subunit : Interacts with CHEK1 and CHEK2; dephosphorylates them.
Similarity : Belongs to the PP2C family. Contains 1 PP2C-like domain.


Catalog Number: (10100-364)
Supplier: Prosci
Description: CENPP is the component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. CENPP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.CENPP is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).


Catalog Number: (BDH7923-2)
Supplier: VWR International
Description: L(+)-Tartaric acid solution 10% (w/v) analytical reagent, VWR Chemicals BDH®

Catalog Number: (BDH4554-500ML)
Supplier: VWR International
Description: Formic acid ≥88.0% ACS, VWR Chemicals BDH®

Catalog Number: (BDH7346-1)
Supplier: VWR International
Description: Per liter formula:
100mLs ACS Phosphoric Acid minimum 85% W/W
900mLs Deionized Water

Catalog Number: (BDH7339-1)
Supplier: VWR International
Description: Per liter formula:
250mLs ACS Sulfuric Acid 95-98% W/W
750mLs Deionized Water

Supplier: VWR International
Description: Made with high purity acid and deionized water. Suitable as a titrant.
Supplier: VWR International
Description: Made with high purity acid and deionized water. Suitable as a titrant.
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