You Searched For: O-Benzyl-L-tyrosine

Catalog Number: (10352-106)

Supplier: Bioss

Description: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.

Catalog Number: (10352-110)

Supplier: Bioss

Description: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.

Catalog Number: (89320-184)

Supplier: Genetex

Description: Rabbit Polyclonal antibody to AXL (AXL receptor tyrosine kinase)

Supplier: TCI America

Description: CAS Number: 54117-37-2
Molecular Formula: C20H15NO
Molecular Weight: 285.35
Purity/Analysis Method: >97.0% (N)
Form: Crystal
Melting point (°C): 134

SDS

Catalog Number: (10109-790)

Supplier: Prosci

Description: Neuregulin 1 (NRG1) interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues.Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells.

Supplier: TCI America

Description: 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Bromide, Purity: >98.0%(GC)(T), Cas number: 138500-85-3, Molecular Formula: C13H18BBrO2, Molecular Weight: 297, Synonyms: 4-(Bromomethyl)phenylboronic Acid Pinacol Ester, Size: 1G

SDS

Catalog Number: (75791-188)

Supplier: Prosci

Description: neuregulin-1 (heregulin-1，NRG1) is a member of neuregulin family, which is comprised of four genes that encode a large number of secreted or membrane-bound isoforms. All family members share an EGF-like domain that interacts with the ErbB family of tyrosine kinase receptors. NRG1 isoforms can be classified into type I, type II and type III isoforms. NRG1 directs ligand for ERBB3 and ERBB4 tyrosine kinase receptors, concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG proteins show distinct spatial and temporal expression patterns and play important roles during development of both the nervous system and the heart.

Catalog Number: (89318-680)

Supplier: Genetex

Description: Rabbit Polyclonal antibody to 14-3-3 theta (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide)

Supplier: TCI America

Description: CAS Number: 622-08-2
MDL Number: MFCD00002868
Molecular Formula: C9H12O2
Molecular Weight: 152.19
Purity/Analysis Method: >98.0% (GC)
Form: Clear Liquid
Boiling point (°C): 256
Flash Point (°C): 130
Specific Gravity (20/20): 1.07

SDS Certificates

Catalog Number: (89357-444)

Supplier: Genetex

Description: Rabbit Polyclonal antibody to 14-3-3 gamma (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide)

Catalog Number: (10457-674)

Supplier: Bioss

Description: Tyrosine kinase of the non-receptor type. Probably performs an important function, perhaps in regulatory processes such as cell cycle control.Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. [provided by RefSeq, Jul 2008].

Catalog Number: (10457-654)

Supplier: Bioss

Description: Tyrosine kinase of the non-receptor type. Probably performs an important function, perhaps in regulatory processes such as cell cycle control.Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. [provided by RefSeq, Jul 2008].

Supplier: TCI America

Description: CAS Number: 17400-34-9
MDL Number: MFCD00270153
Molecular Formula: C11H16N2O2
Molecular Weight: 244.72
Purity/Analysis Method: >98.0% (T)
Form: Crystal
Melting point (°C): 186

SDS

Supplier: Bachem Americas

Description: Sequence: H-Tyr-AMC

Catalog Number: (76107-564)

Supplier: Bioss

Description: May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.

Catalog Number: (10410-270)

Supplier: Bioss

Description: Vital cellular functions such as cell proliferation and signal transduction are regulated in part by the balance between the activities of protein tyrosine kinases (PTK) and protein tyrosine phosphatases (PTPs). The protein contains a 121 residue extracellular domain, a single transmembrane segment, and 2 tandem intracytoplasmic catalytic domains. The PTP alpha protein is ubiquitously expressed and may play a fundamental role in the physiology of all cells.