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Image Unavailable-75977-362

Anti-TOP1MT Mouse Monoclonal Antibody (CF594) [clone: TOP1MT/488]

Supplier: Biotium
Description: DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Product Image-89417-830

Anti-ATP2C2 Rabbit Polyclonal Antibody

Catalog Number: (89417-830)
Supplier: Prosci
Description: ATP2C2 Antibody: ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.
Image Unavailable-CAAAA15744-0F

2-Ethylaminoethanol 98%

Catalog Number: (CAAAA15744-0F)
Supplier: Thermo Scientific Chemicals
Description: 2-Ethylaminoethanol 98%

Certificates


Image Unavailable-76110-648

Anti-FIGNL1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76110-648)
Supplier: Bioss
Description: FIGNL1 is a 674 amino acid protein belonging to the AAA ATPase family. FIGNL1 exists as a hexamer that undergoes alternative splicing to produce two isoforms. FIGNL1 utilizes magnesium as a cofactor and is phosphorylated upon DNA damage, probably by ATM or ATR. FIGNL1 is suggested to regulate osteoblast proliferation and differentiation. FIGNL1 is encoded by a gene located on human chromosome 7, which consists about 158 million bases, encodes over 1000 genes and makes up about 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterized by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance. Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders including cases of acute myelogenous leukemia and myelodysplasia.
Image Unavailable-TCT0851-500G

Tetrabromobisphenol A bis(2-hydroxyethyl)ether ≥93.0%

Supplier: TCI America
Description: CAS Number: 4162-45-2
MDL Number: MFCD00059603
Molecular Formula: C19H20Br4O4
Molecular Weight: 631.98
Purity/Analysis Method: >93.0% (GC)
Form: Crystal
Color: White
Melting point (°C): 119

SDS

Product Image-76307-446

VITsafe™ Safety Wash Bottles, Brandtech

Catalog Number: (76307-446)
Supplier: Brandtech
Description: Wide Mouth VITsafe™ safety wash bottles are made from low-density polyethylene (or Polypropylene for the Acetone bottle). Wash tubes are made of polypropylene.
Image Unavailable-TCC1382-010G

3-Chloro-α-methylbenzyl alcohol ≥98.0%

Catalog Number: (TCC1382-010G)
Supplier: TCI America
Description: CAS Number: 6939-95-3
MDL Number: MFCD00021864
Molecular Formula: C8H9ClO
Molecular Weight: 156.61
Purity/Analysis Method: >98.0% (GC)
Form: Clear Liquid
Boiling point (°C): 246
Flash Point (°C): 110
Specific Gravity (20/20): 1.17

SDS


Image Unavailable-76108-372

Anti-FAHD2A Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76108-372)
Supplier: Bioss
Description: The FAH family contains two highly homologous 314 amino acid proteins, designated FAHD2A (fumarylacetoacetate hydrolase domain-containing protein 2A) and FAHD2B (fumarylacetoacetate hydrolase domain-containing protein 2A). FAHD2A and B utilize calcium and magnesium as cofactors, and may possess hydrolase activity. The genes encoding FAHD2A/B map to human chromosome 2, the second largest human chromosome, which consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr syndrome, is also associated with mutations to chromosome 2.
Image Unavailable-76120-648

Anti-TSSK6 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76120-648)
Supplier: Bioss
Description: The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. TSSK 6 (testis-specific serine kinase 6), also known as SSTK, TSSK4, FKSG82 or CT72, is a 273 amino acid protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase family. Highly expressed in testis with lower expression in ovary, colon, thymus, small intestine and spleen, TSSK 6 catalyzes the ATP-dependent phosphorylation of proteins involved in sperm production and chromatin remodeling. TSSK 6 uses magnesium as a cofactor and is thought to be required for proper sperm development and function, as well as DNA condensation events. Defects in the gene encoding TSSK 6 are associated with male infertility characterized by low sperm count and decreased sperm motility.
Image Unavailable-10489-888

Anti-FIGNL1 Rabbit Polyclonal Antibody

Catalog Number: (10489-888)
Supplier: Bioss
Description: FIGNL1 is a 674 amino acid protein belonging to the AAA ATPase family. FIGNL1 exists as a hexamer that undergoes alternative splicing to produce two isoforms. FIGNL1 utilizes magnesium as a cofactor and is phosphorylated upon DNA damage, probably by ATM or ATR. FIGNL1 is suggested to regulate osteoblast proliferation and differentiation. FIGNL1 is encoded by a gene located on human chromosome 7, which consists about 158 milllion bases, encodes over 1000 genes and makes up about 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterized by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance. Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders including cases of acute myelogenous leukemia and myelodysplasia.
Product Image-102091-094

Wash Bottles, Permanently Labeled/Color-Coded, Electron Microscopy Sciences

Supplier: Electron Microscopy Sciences
Description: Permanently labeled/color-coded wash bottles.

Minority or Woman-Owned Business Enterprise

Image Unavailable-75977-346

Anti-TOP1MT Mouse Monoclonal Antibody (CF488A) [clone: TOP1MT/488]

Supplier: Biotium
Description: DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Image Unavailable-TCT0709-500ML

Triethylene glycol monomethyl ether ≥98.0%

Supplier: TCI America
Description: CAS Number: 112-35-6
MDL Number: MFCD00002875
Molecular Formula: C7H16O4
Molecular Weight: 164.20
Purity/Analysis Method: >98.0% (GC)
Form: Clear Liquid
Color: Colorless
Boiling point (°C): 248
Melting point (°C): -45
Flash Point (°C): 134
Specific Gravity (20/20): 1.05

SDS Certificates

Product Image-10128-796

ENZ-Free, Quality Biological

Catalog Number: (10128-796)
Supplier: QUALITY BIOLOGICAL, INC.
Description: Enz-Free Solution is a proprietary, non-enzymatic solution specially formulated for the non-destructive detachment of adherent cells from culture vessel surfaces. Enz-Free is a gentle dissociation of mammalian cells for studies requiring intact cell surface proteins such as ligand binding, flow cytometry, and immunohistochemistry.

Small Business Enterprise Minority or Woman-Owned Business Enterprise


Image Unavailable-89150-258

Piericidin A (from Streptomyces sp. MST-AS5364) ≥95% (by HPLC)

Catalog Number: (89150-258)
Supplier: Enzo Life Sciences
Description: Antibiotic. Specific and potent inhibitor of NADH-ubiquinone oxidoreductase (complex I) that binds to ubiquinone binding site(s). Inhibits both mitochondrial and bacterial NADH ubiquinone oxidoreductase. Anticancer agent that prevents up-regulation of GRP78, and exhibits cytotoxic activity for etoposide resistant cancer cells under glucose-deprived conditions.
Image Unavailable-10496-326

Anti-TSSK6 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10496-326)
Supplier: Bioss
Description: The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. TSSK 6 (testis-specific serine kinase 6), also known as SSTK, TSSK4, FKSG82 or CT72, is a 273 amino acid protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase family. Highly expressed in testis with lower expression in ovary, colon, thymus, small intestine and spleen, TSSK 6 catalyzes the ATP-dependent phosphorylation of proteins involved in sperm production and chromatin remodeling. TSSK 6 uses magnesium as a cofactor and is thought to be required for proper sperm development and function, as well as DNA condensation events. Defects in the gene encoding TSSK 6 are associated with male infertility characterized by low sperm count and decreased sperm motility.
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