Anti-TOP1MT Mouse Monoclonal Antibody (CF488A) [clone: TOP1MT/488]

Supplier: Biotium

BNC880488-100 BNC880488-500

75977-344EA 325.12 CAD

75977-344 75977-346

Anti-TOP1MT Mouse Monoclonal Antibody (CF488A) [clone: TOP1MT/488]

Antibodies

DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Type: Primary
Antigen: TOP1MT
Clonality: Monoclonal
Clone: Clone TOP1MT/488
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG2b, kappa
Reactivity: Human

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