You Searched For: Diphenyldiazomethane+resin,+polymer-supported

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Diphenyldiazomethane resin, polymer-supported 200-400 mesh

Supplier: Bachem Americas

Description: Diphenyldiazomethane was used industrially for producing benzhydryl esters (diphenylmethyl esters) of β-lactam antibiotics. This "polymeric diphenyldiazomethane" readily reacts with carboxylic acids, e.g. Fmoc-amino acids, which need not to be activated. Products can be cleaved from this very acid-sensitive resin derivative with 1-5 % TFA in dichloromethane.

2-Chlorotrityl chloride, polymer supported

Supplier: Bachem Americas

Description: 2-ClTrt resin, 2-CTC resin Synonyms 2-ClTrt resin, 2-CTC resin Substitution 1.00-2.50 mmol/g Storage Conditions -20 +/- 5 Deg C 25g

4-Methylbenzhydrylamine hydrochloride, polymer supported 100-200 mesh

Supplier: Bachem Americas

Description: Sequence: 4-Methyl-benzhydrylamine resin (100-200 mesh) · HCl
Synonym(s): MBHA resin · HCl#4-CH₃-Ph-CH(NH₂)-Ph-polymer · HCl

SASRIN™ resin (100-200 mesh, 0.7-1.0 mmol/g)

Supplier: Bachem Americas

Description: SASRIN™ (=Super Acid Sensitive ResIN) was developed in our own laboratories especially for Fmoc solid phase synthesis (EP 0 292 729, US 4,831,084 and US 4,914,151). Its high acid lability enables the cleavage and isolation of the protected peptide fragment.

2-Chlorotrityl chloride, polymer supported 200-400 mesh

Supplier: Bachem Americas

Description: A very acid sensitive resin suitable for the synthesis of protected peptide fragments by the Fmoc-strategy. ClTrt resin is in particular suitable for the preparation of C-terminal prolyl and cysteinyl peptides (please see 2-Chlorotrityl Chloride Resin-Linked Amino Acids). Release from this resin is achieved by using 1-50 % TFA in CH₂Cl₂ containing 8 % triisopropylsilane, AcOH/CF₃CH₂OH/CH₂Cl₂, 0.5 % TFA or hexafluoroisopropanol/CH₂Cl₂. ClTrt resin has been used in cyclization reactions under Heck reaction conditions, the solid phase synthesis of β-peptides via the Arndt-Eistert homologation of Fmoc-protected amino acid diazoketones and in Mannich reactions of alkynes, secondary amines and aldehydes in the presence of a copper (I) salt affording the corresponding aminomethylalkynyl adducts. 2-Chlorotrityl resin is highly suitable for the synthesis of peptide alcohols, e.g., peptaibols, and peptide ω-aminoalkylamides.

SASRIN™ resin (200-400 mesh, 0.80-1.20 mmol/g)

Supplier: Bachem Americas

Trityl chloride resin 0.5 - 2.5 mmol/g on poly(styrene-divinylbenzene), cross-linked with 1% DVB 100-200 mesh

Supplier: Thermo Scientific Chemicals

Description: Beads

Certificates

Benzyl mercaptan, polymer supported 2.0-4.0 mmol/g on poly(styrene-divinylbenzene), cross-linked with 1% DVB 100-200 mesh

Supplier: Thermo Scientific Chemicals

Description: Beads

Certificates

Wang resin 200-400 mesh

Supplier: Bachem Americas

Description: The Wang support, p-benzyloxybenzyl alcohol resin, is the most widely used resin for attaching carboxylic acids for further functionalization. Cleavage conditions for the ester anchor involve concentrated TFA or TFA/CH₂Cl₂ to provide carboxylic acids or cyclization-cleavage under acidic or basic conditions. Release of an amide function by treatment with an amine in the presence of a Lewis acid was also reported. Wang resin was used to add vinyl and iodobenzoic acids via carbodiimide coupling and the products subjected to Heck conditions with alkenes or with alkynes or to Suzuki coupling with boron reagents. The Ugi multicomponent condensation reaction was conducted on Wang resin with the carboxylic acid, amine or isonitrile as the anchored functional group. Solid-phase lactam syntheses were also achieved by reaction of the resin-bound isonitrile with an amine and an ω-keto-acid as well as other synthetic transformations such as the Biginelli reaction and construction of heterocycles such as quinolones, imidazoles, hydantoins, and 1,4-benzodiazepine-2,5-diones. On a Wang resin primary, secondary, and tertiary alcohols have been converted to 4-methoxybenzyl ethers. As well as anchoring carboxylic acids to Wang resin, phenols were attached under Mitsunobu conditions, subjected to further transformations and cleaved under acidic conditions.