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Product Image-10750-584

Anti-HAAO Rabbit Polyclonal Antibody

Catalog Number: (10750-584)
Supplier: Prosci
Description: HAAO Antibody: HAAO (3-Hydroxyanthranilate 3, 4-dioxygenase) is a monomeric cytosolic protein of the family of intramolecular dioxygenases containing non-heme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is present in low amounts in the central nervous system. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurological and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. Furthermore, recent study shows that HAAO are excellent candidate biomarkers for detecting ovarian cancer.
Product Image-89417-782

Anti-GLS2 Rabbit Polyclonal Antibody

Catalog Number: (89417-782)
Supplier: Prosci
Description: GLS2 Antibody: Phosphate-activated glutaminase, also known as Glutaminase 2 (GLS2), was initially isolated from rat liver, although it has been shown to be expressed in other tissues. Like the functionally similar, larger kidney glutaminase, GLS2 catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Expression of GLS2 is increased by p53 under both stressed and nonstressed conditions, resulting in increased levels of glutamate and alpha-ketoglutarate, which in turn results in enhanced mitochondrial respiration and ATP generation. GLS2 also regulates antioxidant defense function in cells by increasing reduced glutathione levels and decreasing ROS-levels, suggesting that GLS2 acts as a mediator of p53's role in antioxidant defense in addition to its role in energy metabolism.
Image Unavailable-CAAAH60455-AA

Methyl (±)-lactate 99%

Supplier: Thermo Scientific Chemicals

Certificates

Image Unavailable-N-1555.0005BA

Z-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-Fluoromethylketone

Supplier: Bachem Americas
Description: This specific caspase-3 inhibitor reduces vulnerability to the neuronal death that occurs in the aftermath of kainic acid-evoked status epilepticus (SE).

Image Unavailable-B-2500.0005BA

Fmoc-L-Glu(2-phenylisopropyloxy)-OH

Supplier: Bachem Americas
Description: Sequence: Fmoc-Glu(2-phenylisopropyl ester)-OH

Image Unavailable-TCC0017-025G

Sodium (+/-)-10-camphorsulfonate ≥98.0% (by titrimetric analysis)

Catalog Number: (TCC0017-025G)
Supplier: TCI America
Description: CAS Number: 34850-66-3
MDL Number: MFCD00135623
Molecular Formula: C10H16O4S
Molecular Weight: 254.28
Purity/Analysis Method: >98.0% (T)
Form: Crystal

SDS Certificates


Product Image-10091-260

Anti-NQO2 Rabbit Polyclonal Antibody

Catalog Number: (10091-260)
Supplier: Proteintech
Description: NQO2, also named as QR2 and NMOR2, belongs to the NAD(P)H dehydrogenase (quinone) family. It serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. The cytosolic quinone oxidoreductases NQO1 and NQO2 protect cells against oxidative stress by detoxifying quinones and preventing redox cycling. NQO1 and NQO2 are important endogenous factors in regulation of immune response and autoimmunity.
Product Image-10075-376

Anti-GRIN1 Rabbit Polyclonal Antibody

Catalog Number: (10075-376)
Supplier: Prosci
Description: The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s disease, epilepsy and ischemic neuronal cell death. Increased membrane surface expression of the NR1 subunit of the receptor has been associated with synaptic plasticity. There are a number of different splice variants of the NR1. Differential splicing of three exons in the NR1 subunit generates up to eight NR1 splice variants and 7 of these have been identified in cDNA libraries. These exons encode a 21 amino acid N-terminal domain (N1) and adjacent sequences in the C-terminus (C1 and C2). Splicing out the C2 cassette eliminates the first stop codon and produces a new reading frame that generates a new sequence of 22 amino acids (C2'). Considerable attention has been focused on the distribution and expression of these splice variants that may affect the functional properties and regulation of the NMDAR.
Product Image-10075-378

Anti-GRIN1 Rabbit Polyclonal Antibody

Catalog Number: (10075-378)
Supplier: Prosci
Description: The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s disease, epilepsy and ischemic neuronal cell death. Increased membrane surface expression of the NR1 subunit of the receptor has been associated with synaptic plasticity. There are a number of different splice variants of the NR1. Differential splicing of three exons in the NR1 subunit generates up to eight NR1 splice variants and 7 of these have been identified in cDNA libraries. These exons encode a 21 amino acid N-terminal domain (N1) and adjacent sequences in the C-terminus (C1 and C2). Splicing out the C2 cassette eliminates the first stop codon and produces a new reading frame that generates a new sequence of 22 amino acids (C2'). Considerable attention has been focused on the distribution and expression of these splice variants that may affect the functional properties and regulation of the NMDAR.
Image Unavailable-TCT0954-005G

L-Theanine ≥98.0% (by titrimetric analysis)

Supplier: TCI America
Description: CAS Number: 3081-61-6
MDL Number: MFCD00059653
Molecular Formula: C7H14N2O3
Molecular Weight: 174.20
Purity/Analysis Method: >98.0% (T)
Form: Crystal
Color: White
Melting point (°C): 207
Specific rotation [a]20/D: 8 deg (C=5, H2O)

SDS Certificates

Image Unavailable-TCB3376-5G

1-Boc-piperidine-3-carboxylic acid ≥97.0% (by GC, titration analysis)

Supplier: TCI America
Description: CAS Number: 84358-12-3
MDL Number: MFCD00673775
Molecular Formula: C11H19NO4
Molecular Weight: 229.28
Purity/Analysis Method: >97.0% (GC,T)
Form: Crystal
Melting point (°C): 160

SDS Certificates

Image Unavailable-10092-886

Anti-PSMA/GCPII Rabbit Polyclonal Antibody

Catalog Number: (10092-886)
Supplier: Proteintech
Description: PSMA(Prostate-specific membrane antigen) is also named as FOLH1, FOLH, NAALAD1, PSM and belongs to the peptidase M28 family. PSMA is a 100-120 kDa integral transmembrane glycoprotein, considered to be a highly specific marker of the prostate gland, and has successfully been used as a marker of circulating prostatic epithelial cells. It is involved in conversion of the major neurotransmitter (NAAG) to NAA and free glutamate. It has 8 isoforms produced by alternative splicing.
Image Unavailable-89360-084

Anti-PICK1 Rabbit Polyclonal Antibody

Catalog Number: (89360-084)
Supplier: Genetex
Description: PSD-95/DLG/ZO-1 (PDZ) domain-containing proteins play a central role in synaptic membrane protein localization. The protein interacting with protein kinase C (PICK 1) is a synaptic PDZ domain protein that also contains a coiled-coil and acidic domain. Studies indicate that PICK 1 functions as a targeting and transport protein and has been shown to interact with protein kinase C alpha (PKC alpha), AMPA-type glutamate receptors, and several other membrane receptors via its PDZ domain. The interaction of PICK 1 with PKC alpha is highly dependent on the activation of the kinase. It appears that PICK 1 directs the activated form of PKC alpha to membrane anchored GluR2. Once phosphorylated by PKC alpha, GluR2 is released from the synaptic anchor proteins. Once released, GluR2 is transported from the synaptic membrane in a PICK 1-dependent manner.
Image Unavailable-CAAAA15606-14

1-Acetylpiperidine-4-carboxylic acid 98+%

Supplier: Thermo Scientific Chemicals
Description: 1-Acetylpiperidine-4-carboxylic acid 98+%

Certificates

Image Unavailable-TCB4368-25G

N-(tert-Butoxycarbonyl)iminodiacetic acid ≥98.0% (by HPLC, titration analysis)

Supplier: TCI America
Description: CAS Number: 56074-20-5
MDL Number: MFCD00800351
Molecular Formula: C9H15NO6
Molecular Weight: 233.22
Purity/Analysis Method: >98.0% (HPLC,T)
Form: Crystal
Melting point (°C): 126
Storage Temperature: 0-10°C

SDS

Image Unavailable-10662-794

Anti-GABRB3 Rabbit Polyclonal Antibody

Catalog Number: (10662-794)
Supplier: Bioss
Description: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel..GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct.
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