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Product Image-10088-310

Anti-HLA-E Rabbit Polyclonal Antibody

Catalog Number: (10088-310)
Supplier: Proteintech
Description: Human major histocompatibility complex (MHC) antigens, also referred to as human leukocyte antigens (HLA), are encoded by genes located on the short arm of chromosome 6 (6p21.3). There are two classes of HLA antigens: class I and class II. This class I molecules are membrane glycoproteins composed of a heavy (alpha) chain which is encoded by a HLA class I gene, and β2-microglobulin light (beta) chain. The most extensively characterized members of the HLA class I gene family are the genes encoding the major transplantation antigenes, HLA-A, B and C. HLA-E is a non-classical MHC class I molecule.
Product Image-10102-592

Anti-CLEC4M Rabbit Polyclonal Antibody

Catalog Number: (10102-592)
Supplier: Prosci
Description: CLEC4M is a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.This gene encodes a type II integral membrane protein that is 77% identical to CD209 antigen, a HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
Product Image-10822-214

Mouse Recombinant IL-27/P28 (from E. coli)

Catalog Number: (10822-214)
Supplier: FUJIFILM IRVINE SCIENTIFIC, INC
Description: The p28 subunit of interleukin 27 (IL-27), also known as interleukin 30 (IL-30), is a member of the interleukin 12 (IL-12) family of cytokines. p28 is a secreted polypeptide that associates with the Epstein-Barr virus induced gene 3 (EBI3) to form the IL-27 cytokine heterodimer complex. IL-27 functions as a proinflammatory cytokine that induces immunomodulatory effects in naïve CD4+ T cells, mast cells, and monocytes. p28 can also form a complex with cytokine-like factor 1 (CLF), that is secreted by dendritic cells, to regulate natural killer (NK) and T cell functions.
Product Image-10672-014

Anti-RNF17 Rabbit Polyclonal Antibody

Catalog Number: (10672-014)
Supplier: Bioss
Description: The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF17 (ring finger protein 17) or tudor domain-containing protein 4, TDRD4, SPATA23, Mmip-2 or FLJ11045, is a testis-specific protein and and novel key regulator of spermiogenesis containing 1,623 amino acids. By distributing Mad proteins to the cytoplasm, RNF17 regulates the transcriptional activity of c-Myc. Although showing localization in the nucleus, RNF17 is predominantly observed in cytoplasm and is a component of a novel nuage found in male germ cells. The gene encoding RNF17 maps to human chromosome 13q12.12 and encodes one RING-type zinc finger and four tudor domains. As a result of alternative splice events, five RNF17 isoforms exisit.
Product Image-CAJTF781-5

Dithiothreitol (DTT, Cleland's reagent) ≥99.0%, Biotech Reagent, J.T.Baker®

Catalog Number: (CAJTF781-5)
Supplier: VWR International
Description: White crystals. Keep material refrigerated between 2 to 8°C.

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Product Image-10822-216

Mouse Recombinant IL-27/P28 (from E. coli)

Catalog Number: (10822-216)
Supplier: FUJIFILM IRVINE SCIENTIFIC, INC
Description: The p28 subunit of interleukin 27 (IL-27), also known as interleukin 30 (IL-30), is a member of the interleukin 12 (IL-12) family of cytokines. p28 is a secreted polypeptide that associates with the Epstein-Barr virus induced gene 3 (EBI3) to form the IL-27 cytokine heterodimer complex. IL-27 functions as a proinflammatory cytokine that induces immunomodulatory effects in naïve CD4+ T cells, mast cells, and monocytes. p28 can also form a complex with cytokine-like factor 1 (CLF), that is secreted by dendritic cells, to regulate natural killer (NK) and T cell functions.
Image Unavailable-10092-412

Anti-PLA2G12A Rabbit Polyclonal Antibody

Catalog Number: (10092-412)
Supplier: Proteintech
Description: PLA2G12A (or PLA2G12) gene encodes group XII secreted phospholipase A2 (sPLA2) which catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Cellular arachidonate (AA) release and prostaglandin (PG) production is regulated by sPLA(2)s, groups III and XII. Group XII sPLA2 have relatively low specific activity and are structurally and functionally distinct from other sPLA2s. Cells transfected with group XII sPLA(2) exhibited abnormal morphology, suggesting a unique functional aspect of this enzyme. Role of sPLA2s as potential tumour biomarkers and therapeutic targets for various cancers have been reported.
Product Image-77001-228

DNA Clean and Concentrator™ Kits, Zymo Research

Supplier: Zymo Research
Description: Clean and concentrate up to 5 μg DNA with ≥6 μL elution in as little as 2 minutes with 0 μL wash residue carryover.

Product Image-76020-604

RNA Clean & Concentrator™ Kits, Zymo Research

Supplier: Zymo Research
Description: The RNA Clean & Concentrator™ (RCC™) kits facilitate the efficient removal of RNA polymerases, ligases, and RNA modifying enzymes.

Product Image-10018-870

VWR® Basic Reach-In Freezers with Natural Refrigerant

Catalog Number: (10018-870)
Supplier: VWR International
Description: Upright freezers with 1-, 2-, or 3-doors, these freezers maintain –10 °F (–23.3 °C).
Product Image-10750-158

Anti-RGPD5 Rabbit Polyclonal Antibody

Catalog Number: (10750-158)
Supplier: Prosci
Description: RGPD5 Antibody: The RANBP2-like and GRIP domain containing 5 protein (RGPD5) has high similarity to RANBP2, a large RAN-binding protein localized at the cytoplasmic side of the nuclear pore complex. The gene coding for RGPD5 is thought to have arisen from a gene duplication event of RANBP2 as these highly homologous genes are located close to each other at chromosome 2q11-q12. RGPD5 was identified as an HIV dependency factor (HDF), suggesting that RGPD5 may be an important drug target in HIV treatment. At least two isoforms of RGPD5 are known to exist, of which the shorter isoform is expressed primarily in testis, while the longer of the two is expressed at low levels in a number of somatic tissues.
Product Image-89239-086

Accessories for VWR® Chromatography Refrigerators with Glass Doors

Supplier: VWR International
Description: Full shelf kit for 651 L refrigerators, 22.56×23.25", 10 lbs, additional full white wire shelf can be ordered for any GDM-23 model

Image Unavailable-TCA0528-025G

L-Arginine hydrochloride ≥98.0% (by HPLC, titration analysis)

Supplier: TCI America
Description: CAS Number: 1119-34-2
MDL Number: MFCD00064550
Molecular Formula: C6H14N4O2
Molecular Weight: 210.66
Purity/Analysis Method: >98.0% (HPLC,T)
Form: Crystal
Melting point (°C): 235
Specific rotation [a]20/D: 23 deg (C=8, HCl(1+1))

SDS Certificates

Product Image-77001-330

Oligo Clean & Concentrator™, Zymo Research

Supplier: Zymo Research
Description: Quick (2 minute) recovery of ultra-pure DNA and RNA oligonucleotides.

Product Image-76457-500

VWR® Disposable Scalpels with Measurements

Catalog Number: (76457-500)
Supplier: VWR International
Description: VWR® Sterile Disposable Scalpels are mounted on plastic handles with fluted finger-grips.
Product Image-10088-334

Anti-HMGB1 Rabbit Polyclonal Antibody

Catalog Number: (10088-334)
Supplier: Proteintech
Description: The HMG (high mobility group) proteins are nonhistone chromosomal proteins that is present in almost all eukaryotic cells, and it functions to stabilize NUCLEOSOME formation and acts as a transcription-factor-like protein that regulates the expression of several genes. Once injury, infection or other inflammatory stimuli, activated macrophages, mature dendritic cells and natural killer cells can secret HMGB1, which act as a crucial cytokine. HMGB1 also involved in V(D)J recombination by acting as a cofactor of the RAG complex, stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Act as a Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. HMGB1 (high mobility group box 1) modulates gene expression in the nucleus, but certain immune cells secrete HMGB1 as an extracellular Alarmin to signal tissue damage.The nuclear HMGB1 relocalizes to the extracellular milieu in senescent human and mouse cells in culture and in vivo, which stimulated cytokine secretion through TLR-4 signaling (23649808).This antibody is a rabbit polyclonal antibody raised against full length HMGB1 of human origin.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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