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You Searched For: 1,2-Dichloroethane-[D4]


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Mouse Recombinant LAG3

Catalog Number: (75791-664)
Supplier: Prosci
Description: Lymphocyte-activation gene 3 (LAG3), also known as CD223, is a type I transmembrane protein with four extracellular Ig-like domains, designated D1 to D4 and belongs to the immunoglobulin superfamily. The gene for LAG3 lies adjacent to the gene for CD4 on human chromosome 12p13.32 and shares approximately 20% identical to the CD4 gene. LAG3 is expressed on activated T cells, natural killer cells, B cells and plasmacytoid dendritic cells. LAG3 binds with high affinity to MHC class II molecules, and it interferes competitively with the binding of CD4 to MHC class II and thereby blocks the transduction of stimulatory signals mediated by this interaction. LAG3 negatively regulates cellular proliferation, activation, and homeostasis of T cells, and plays an important role in Treg suppressive function. LAG3 is the target of various drug development programs to develop new treatments for cancer and autoimmune disorders. The soluble form, sLAG-3, is being developed as a cancer drug.
Image Unavailable-75793-998

Human Recombinant LAG3 (from CHO cells)

Catalog Number: (75793-998)
Supplier: Prosci
Description: Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
Image Unavailable-75793-988

Human Recombinant LAG3 (from CHO cells)

Catalog Number: (75793-988)
Supplier: Prosci
Description: Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
Image Unavailable-CAAA22980-03

Ammonia-D3 23.0 - 27.0% (w/w) in D₂O , 99% (Isotopic)

Catalog Number: (CAAA22980-03)
Supplier: Thermo Scientific Chemicals
Description: Ammonia-D3 23.0 - 27.0% (w/w) in D₂O , 99% (Isotopic)

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Product Image-89141-442

Anti-DopamineR D1 Rabbit Polyclonal Antibody

Catalog Number: (89141-442)
Supplier: Enzo Life Sciences
Description: Dopamine is the predominant catecholamine neurotransmitter in the mammalian brain, where it regulates locomotor, emotional, memory, and dietary intake functions, as well as peripheral roles such as hormone secretion and renal function. Dopamine receptors (D1-D5) are members of the seven transmembrane domain containing G-protein coupled receptor (GPCR) family A, and are the target of several anti-psychosis and anti-Parkinsonian drugs. The D2, D3, and D4 dopamine receptors are encoded by homologous intron-containing genes, and signal via coupling of Gi/Go alpha G-protein subunits to inhibit adenylyl cyclase activity, as well as modulate cellular ion channel conductance of K+ and Ca2+. This is in contrast to D1 and D5 dopamine receptors, which signal via Gs alpha subunits to activate adenylyl cyclase activity. Coactivation of D1 and D2 receptors has been shown to activate a Gq mediated pathway, stimulating phospholipase C (PLC) and mobilizing intracellular calcium stores. D1 receptors were initially characterized in the striatum and retina and are expressed throughout the brain in the olfactory tubercle, islands of Calleja, entopeduncular nucleus, neocortex, hippocampus, and amygdala. Expression of the D2 receptor is found primarily in the brain (striatum, olfactory tubercle, and nucleus accumbens) and in the anterior and intermediate lobes of the pituitary.
Product Image-BDH4566-4L

(±)-1,2-Propanediol ≥99.5% ACS, VWR Chemicals BDH®

Catalog Number: (BDH4566-4L)
Supplier: VWR International
Description: (±)-1,2-Propanediol ≥99.5% ACS, VWR Chemicals BDH®

SDS Certificates


Product Image-93000-044

VWR® Sample Library Tubes and Closures, 1.2 ml

Supplier: VWR International
Description: These 1.2 ml Library and Cluster Tubes are ideal for storage, dilution, mixing, harvesting, culture assays and screening based assays.

Certificates Environmentally Preferable

Product Image-76358-584

VWR® 12-Channel Reagent Reservoirs

Supplier: VWR International
Description: These 12-channel reservoirs are made from high-quality, chemical resistant PP.

Image Unavailable-VF-ALS12L60

Accessories for VWR® Modular Workstations for 60×30×30' and 60×30×36'

Supplier: VWR International
Description: Powerstrip with 12 outlets

Product Image-83009-678

Accessories for VWR® 1.2 ml Sample Library Tubes and Closures

Supplier: VWR International
Description: Immunology Tubes, 12-Well Closure Strips, Sterile

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Accessories for VWR® Modular Workstations for 72×30×30" and 72×30×36"

Supplier: VWR International
Description: Powerstrip with 12 outlets

Product Image-77752-186

Mouse Recombinant IL-12 (from HEK293 cells)

Supplier: VWR International
Description: <p>Interleukin 12 (IL-12) is an inducer of cell-mediated immunity and is produced by dendritic cells, macrophages, and B cells after antigen stimulation. IL-12 functions to promote naïve T cell differentiation into the type 1 T helper cell (Th1) lineage. IL-12 also stimulates the production of interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α) from T cells and natural killer cells. Mouse IL-12 is active on human and mouse cells.</p>

New Product

Product Image-MFLX98305-32

Masterflex® Particle Tolerant Solenoid Valves, Avantor®

Supplier: VWR International
Description: Particles will not cause damage.

Product Image-10144-840

Accessories for VWR® Shaking Water Baths

Supplier: VWR International
Description: Shaking Bath, VWR® Tray Universal for 12 L Unit

Product Image-97008-282

VWR®, Accessories for VWR® CryoPro® Auto-Fill Vapor Phase Systems AF-VPS

Catalog Number: (97008-282)
Supplier: VWR International
Description: Cryopreservation system, 1.2 m (4') Stainless Steel Armor Plated Hose

Small Business Enterprise


Product Image-77575-254

VWR® 12-Channel Polypropylene Reagent Reservoirs

Supplier: VWR International
Description: These 12-channel reservoirs are made from high-quality, chemical resistant PP. Designed for serial dilutions or pipetting individual reagents using up to 12-channel pipetters.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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