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You Searched For: PARKER HANNIFIN TE


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Image Unavailable-10447-824

Anti-CPE Rabbit Polyclonal Antibody (Cy5®)

Description: Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.
Catalog Number: 10447-824
Supplier: Bioss
Image Unavailable-76101-378

Anti-KLK1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Description: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
Catalog Number: 76101-378
Supplier: Bioss
Image Unavailable-76116-394

Anti-Carboxypeptidase H Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Description: Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.
Catalog Number: 76116-394
Supplier: Bioss
Image Unavailable-103009-600

[Arg(Me2s)26]-Histone H3 (15-36)-GGK,Biotin

Description: This peptide is Histone H3 amino acid residues 15-36 with a C-terminal GG linker followed by a biotinylated lysine. It is symmetrically dimethylated at arginine 26 with a methyl group added to each nitrogen of the guanidinium group.
Sequence:APRKQLATKAA-R(Me2s)-KSAPATGGVK-GGK(biotin)
MW:2704.2 Da
% peak area by HPLC:95
Storage condition:-20° C
Catalog Number: 103009-600
Supplier: Anaspec Inc
Image Unavailable-M-1895.0005BA

Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH₂ Trifluoroacetate

Description: Mca-PLGL-Dpa-AR-amide is a very sensitive FRET substrate for continuous assays and in situ determination of the matrix metalloproteinase activity. Cleavage at the Gly-Leu bond separates the highly fluorescent Mca group from the efficient 2,4-dinitrophenyl quencher, resulting in an increase in fluorescence intensity. The kcat/Km values for the punctuated metalloproteinase (MMP-7) and for gelatinase (MMP-2), e.g., are 1.7·10⁵ and 6.3·10⁵ M⁻¹s⁻¹, respectively.
Catalog Number: M-1895.0005BA
Supplier: Bachem Americas
Image Unavailable-102996-074

Human Atrial Natriuretic Peptide (1-28)

Description: One of the three mammalian Natriuretic peptides, A-type is the Atrial natriuretic peptide (ANP) also called Cardiodilatin (CDD). ANP (1-28) peptide hormone constitutes the first 28 amino acids of the ANP synthesized in the heart of different vertebrates. It plays an important role in the regulation of blood pressure and natriuresis/diuresis. Residues Phe8, Arg14 and the C-terminal sequence of ANP are known to bind to human NPR-A (Natriuretic peptide receptor type A).
Sequence:SLRRSSCFGGRMDRIGAQSGLGCNSFRY (Disulfide bridge: 7-23)
MW:3080.5 Da
%Peak area by HPLC:≥95%
Storage condition: -20°C
Catalog Number: 102996-074
Supplier: Anaspec Inc
Image Unavailable-I-1400.0025BA

Boc-Phe-Ser-Arg-AMC Acetate

Description: The fluorogenic substrate Boc-FSR-AMC is preferentially hydrolyzed by coagulation factor XIa. Boc-FSR-AMC is also highly susceptible to the proteases in yeast mitochondrial matrix as well as to tryptase from rat mast cells. In addition, the substrate is cleaved by acrosin from the ascidian Halocynthia roretzi.
Catalog Number: I-1400.0025BA
Supplier: Bachem Americas
Image Unavailable-N-1325.0005BA

H-Glu-Gly-Arg-chloromethylketone Trifluoroacetate

Description: Peptide and amino acid chloromethyl ketones (CMK's) are irreversible inhibitors of cysteine proteases, but they also react with serine proteases. For our amino acid CMK's (e.g. TPCK, TLCK) see the corresponding product family in the 'Amino acid' section.
Catalog Number: N-1325.0005BA
Supplier: Bachem Americas
Image Unavailable-10394-594

Anti-CARM1 Rabbit Polyclonal Antibody (Cy3®)

Description: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.
Catalog Number: 10394-594
Supplier: Bioss
Image Unavailable-H-3276.0025BA

(D-Ala²)-Leu-Enkephalin-Arg Trifluoroacetate

Description: For other opioid peptides see, the product families ‘Deltorphins and Dermorphins’, ‘Endorphins, MPF, Neoendorphins’, and ‘Opioid Peptides'.
Catalog Number: H-3276.0025BA
Supplier: Bachem Americas
Image Unavailable-M-2105.0005BA

Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH₂ Trifluoroacetate

Description: The FRET substrate Mca-RPKPYA-Nva-WMK(Dnp)-amide was hydrolyzed 60 times more rapidly by stromelysin 1 (MMP-3) (kcat/Km= 59400 M⁻¹s⁻¹) than by interstitial collagenase (MMP-1). However, it showed little discrimination between MMP-3, gelatinase A (MMP-2) (kcat/Km= 54000 M⁻¹s⁻¹), and gelatinase B (MMP-9) (kcat/Km= 55300 M⁻¹s⁻¹). Metalloelastase (MMP-12) digested this fluorogenic substrate with a kcat/Km of 243000 M⁻¹s⁻¹. For a fluorescent standard see M-2250.
Catalog Number: M-2105.0005BA
Supplier: Bachem Americas
Image Unavailable-76077-560

Anti-CARM1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Description: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.
Catalog Number: 76077-560
Supplier: Bioss
Image Unavailable-76119-660

Anti-DCTN6 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Description: DCTN6 belongs to the pointed end complex of the dynactin shoulder complex tpgether with the DCTN4, DCTN5 and DCTN6 subunits and ACTR10. DCTN6 contains an RGD (Arg-Gly-Asp) motif in the N terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. The exact function of this gene is not known.
Catalog Number: 76119-660
Supplier: Bioss
Image Unavailable-H-4766.0500BA

Human GLP-2 (1-34) Trifluoroacetate

Description: For the long-acting GLP-1 analog liraglutide see H-6724.
Catalog Number: H-4766.0500BA
Supplier: Bachem Americas
Image Unavailable-J-1120.0050BA

Z-Gly-Pro-Arg-4MbetaNA Acetate

Description: Z-GPR-MNA, a thrombin substrate which has been modeled after a thrombin cleavage site in human fibrinogen, can be used for a sensitive assay of antithrombin III activity. Z-GPR-MNA is also cleaved by cathepsin K and granzyme A and, according to Valchanov et al., a most efficient substrate for the demonstration of rat mast cell tryptase in histochemistry.
Catalog Number: J-1120.0050BA
Supplier: Bachem Americas
Image Unavailable-10344-006

Anti-IBSP Rabbit Polyclonal Antibody (Cy5.5®)

Description: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
Catalog Number: 10344-006
Supplier: Bioss
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