You Searched For: FUJIFILM IRVINE SCIENTIFIC, INC

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Description: Interleukin 5 (IL-5) is a hematopoietic growth factor that is expressed in type 2 T helper (Th2) cells, mast cells, and eosinophils. IL-5 acts through the IL-5 receptor (IL-5R), stimulates B cell growth, and mediates eosinophil activation. IL-5 expression is regulated by the GATA binding protein 3 (GATA3) transcription factor. Human and mouse IL-5 show cross-reactivity.

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Description: Ciliary neurotrophic factor (CNTF) is a neurotrophic factor that promotes the survival of neuronal cell populations, neurite outgrowth, and neurotransmitter synthesis. CNTF also plays an important protective role during nervous system injury.

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Description: Growth hormone (GH) is an important mitogenic growth factor that is synthesized, stored, and secreted by somatotropic cells of the anterior pituitary gland. GH stimulates growth, cell reproduction, and cell regeneration. In children, GH deficiencies can cause short stature, growth failure, and delayed sexual maturity. Adult GH deficiency presents with reduced lean body mass, increased adiposity, reduced muscle strength, and ultimately premature mortality. GH replacement therapy is used to treat many growth disorders, including Turner syndrome, chronic renal failure, and Prader–Willi syndrome.

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Description: Interferon gamma (IFNγ) is a type II interferon that is critical during adaptive and innate immune responses to infection. IFNγ is produced by T cells and natural killer cells following antigen-specific activation. IFNγ binds IFNγ receptors (IFNγR1 and IFNγR2), which are expressed on most immune cells, to activate the JAK-STAT pathway. IFNγ-induced signaling increases the expression of class 1 major histocompatibility complex (MHC) molecules. Human IFNγ is not cross-reactive with mouse IFNγ.

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Description: Interleukin 29 (IL-29), also known as IFN-λ, is a type III interferon produced by virally infected cells. IL-29 plays an important role in host defenses against microbes and antiviral activity. IL-29 shares homology with interleukin 28 (IL-28) and binds the class II cytokine receptor IL-28R.

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Description: Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes.  IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Description: SCF is a multipotent factor which affects cells of the myeloid, erythroid, mast, and lymphoid lineages.

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Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Description: CTGrade GMP rh IL-7 is a recombinant human protein that is produced from <i>E. coli</i> and is designed to support basic, translational, and clinical research, as well as commercial applications.

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Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Description: Persephin is a neurotrophic factor of the glial cell line-derived neurotrophic factor (GDNF) family. Persephin promotes survival and growth of dopaminergic and motor neurons, but not peripheral neurons. Persephin is a ligand for the RET receptor tyrosine kinase.

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Description: Prolactin is a hormone that is produced and secreted by the pituitary gland. Prolactin acts in an endocrine, paracrine, and autocrine manner. The prolactin receptor (PRLR) is expressed on many cell types, including cells of the reproductive organs, central nervous system, and breast cancer. Prolactin signal transduction occurs via JAK kinase signaling pathways. The primary function of prolactin is to regulate lactation, but prolactin also plays functional roles in the immune system and during cell growth, apoptosis, and differentiation.

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Description: Interleukin 36 gamma (IL-36 ɣ) is a member of the interleukin 1 (IL-1) cytokine family and protects against pathogens in the skin, lung, and stomach epithelial barriers. IL-36 ɣ binds the interleukin-1 receptor accessory protein (IL-1RAcP) and the orphan IL-1R-related protein 2 (IL-1Rrp2) receptors to activate NF-kB and MAP kinase signaling pathways, resulting in the induced production of inflammatory cytokines and chemokines.

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Description: Stromal cell-derived factor-1 beta (SDF-1 β), also called CXCL12b, is one of two SDF-1 splice variants made by a wide variety of cells upon stimulation by inflammatory cytokines such as TNF, IL-1, and LPS. SDF-1 β signals through the G protein-coupled receptor CXCR4 to recruit activated leukocytes.

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Description: Thrombopoietin (TPO) is a growth factor that is produced by liver and kidney tissues. TPO binds the TPO receptor (CD110) to promote megakaryocyte maturation, differentiation, and the production of platelets. Human TPO (CHO) contains a C-terminal 6x-polyhistidine (6xHis) tag.

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Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Description: Macrophage inflammatory protein-3 beta (MIP-3 β), also called CCL19, is a chemokine that is expressed in the thymus, lymph nodes, and activated bone marrow stromal cells. MIP-3 β signals through the G protein-coupled receptor CCR7 to regulate normal lymphocyte recirculation. MIP-3 β also functions during T cell trafficking to the thymus, and in T cell and B cell homing to the lymph nodes and secondary lymphoid organs. Human MIP-3 β shows activity on mouse cells.

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Description: Interferon-inducible T cell alpha chemoattractant (I-TAC), or CXCL11, is expressed at high levels in leukocytes, pancreas, and liver cells. I-TAC gene expression is induced by interferons alpha (IFN-α), beta (IFN-β), and gamma (IFN-ɣ). I-TAC is the dominant ligand known to bind the chemokine receptor CXCR3, thus acting as a stronge agonist. I-TAC functions as a chemoattractant for interleukin 2 (IL-2)-activated T cells.

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Description: Tumor necrosis factor alpha (TNF-α) is an inflammatory cytokine secreted by macrophages, monocytes, neutrophils, T cells, and NK-cells following stimulation by bacterial lipopolysaccharide (LPS). TNF-α signal activation occurs through two receptors, TNFR1 and TNFR2. TNFR1 is expressed on most cell types, unlike TNFR2, which is expressed mainly on immune cells. TNF-α functions to stimulate phagocytosis in macrophages, chemoattract neutrophils, increase insulin resistance, and induce fever.

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