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Catalog Number: (CAPIPA5-16847)

Supplier: Thermo Scientific

Description: This Antibody targets MUC-1 in IHC (P) applications and shows reactivity with Human and mouse samples. The immunogen is a synthetic peptide from cytoplasmic tail of human MUC-1 protein. MUC-1 is a heavily O-glycosylated transmembrane protein expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC-1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands.

Catalog Number: (CAPIPA5-18500)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with canine and mouse based on sequence homology. The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif . Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.

Catalog Number: (CAPIPA5-18547)

Supplier: Thermo Scientific

Description: The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine , a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified.

Catalog Number: (CAPIPA5-18051)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with canine, mouse and rat based on sequence homology. The prompt clearance of cells undergoing apoptosis is critical during embryonic development, normal tissue turnover, inflammation, and autoimmunity. CED6 is an evolutionarily conserved adaptor protein required for efficient engulfment of apoptotic cells by phagocytes.

Catalog Number: (CAPIPA5-13467)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine, chicken, canine, equine, hamster, mouse, porcine, non-human primate, rat, rabbit and Xenopus, yeast and zebrafish based on sequence homology. Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, is a cytoplasmic actin found in nonmuscle cells.

Catalog Number: (CAPIPA5-18254)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine, canine, mouse and porcine based on sequence homology. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.

Catalog Number: (CAPIPA5-13663)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with rat based on sequence homology. KRT10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in its gene are associated with epidermolytic hyperkeratosis.

Catalog Number: (CAPIPA5-13523)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with mouse and rat based on sequence homology. Annexin 5 belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII.

Catalog Number: (CAPIPA525989)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with mouse, non-human primate and rat based on sequence homology. HCK is a member of the Srcfamily of tyrosine kinases. This protein is primarily hemopoietic,particularly in cells of the myeloid and B-lymphoid lineages. Itmay help couple the Fc receptor to the activation of therespiratory burst. In addition, it may play a role in neutrophilmigration and in the degranulation of neutrophils. Multipleisoforms with different subcellular distributions are produced dueto both alternative splicing and the use of alternative translationinitiation codons, including a non-AUG (CUG) codon.

Catalog Number: (CAPIPA5-18786)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with mouse based on sequence homology.

Catalog Number: (CAPIPA5-18390)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with canine, human, mouse and porcine based on sequence homology. This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen.

Catalog Number: (CAPIPA525931)

Supplier: Thermo Scientific

Description: PDK3 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.

Catalog Number: (CAPIPA5-18092)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with mouse and rat based on sequence homology. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S27E family of ribosomal proteins. It contains a C4-type zinc finger domain that can bind to zinc. The encoded protein has been shown to be able to bind to nucleic acid. It is located in the cytoplasm as a ribosomal component, but it has also been detected in the nucleus. Studies in rat indicate that ribosomal protein S27 is located near ribosomal protein S18 in the 40S subunit and is covalently linked to translation initiation factor eIF3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Catalog Number: (CAPIPA5-14672)

Supplier: Thermo Scientific

Description: Alpha-L-fucosidase catalyzes the hydrolysis of terminal alpha-L-fucosidase linkages in glycosphingolipids and glycoproteins. At least 2 separate polymorphic alpha-L-fucosidases are recognized in man. The FUCA2 locus regulates the level of alpha-fucosidase in plasma and fibroblasts but not in leukocytes. In fucosidosis, deficiency of alpha-L-fucosidase is found in both plasma and leukocytes.

Catalog Number: (CAPIPA5-18809)

Supplier: Thermo Scientific

Description: Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targetted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Catalog Number: (CAPIPA526128)

Supplier: Thermo Scientific

Description: ADAMDEC1 may play an important role in the control of the immune response and during pregnancy.