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Supplier: Enzo Life Sciences
Description: Retinoic acid analog which acts as a selective RARα agonist with no affinity for RXRs. Induces differentiation in leukemia cell lines and inhibits angiogenesis in chick embryos.

Catalog Number: (89141-424)
Supplier: Enzo Life Sciences
Description: Glycogen Synthase Kinase 3β (GSK-3β) is a unique serine/threonine kinase that is inactivated by phosphorylation. In response to insulin binding, PKB/AKT phosphorylates GSK-3β on serine 9, which prevents GSK-3β from phosphorylating glycogen synthase. Unphosphorylated glycogen synthase is active and able to synthesize glycogen. GSK-3β is also unique in that it requires a substrate that has been phosphorylated by a distinct kinase before it can phosphorylate the substrate. This phosphate priming mechanism explains why phosphorylation of serine 9 inactivates GSK-3β. The phosphorylated serine binds to the GSK-3β priming phosphate position and prevents binding of alternative substrates. In addition to insulin signaling, GSK-3β participates in the Wnt signaling pathway, where it forms a complex with axin, beta-catenin and adenomatous polyposis coli (APC) protein. In the presence of Wnts, GSK-3β is unable to phosphorylate beta-catenin, which leads to stabilization of beta-catenin. The Wnt pathway inactivates GSK-3β via the proteins, Dishevelled and FRAT, which disrupt the interaction of GSK-3β with axin, beta-catenin, and APC. Clinically, there is considerable interest in GSK-3β inhibitors because they may mimic the effect of insulin or reduce the hyperphosphorylation of Tau that is observed in Alzheimer's Disease.


Catalog Number: (89160-142)
Supplier: Enzo Life Sciences
Description: Host: Mouse, Isotype: IgG1


Catalog Number: (89151-408)
Supplier: Enzo Life Sciences


Catalog Number: (89166-034)
Supplier: Enzo Life Sciences
Description: DNA dye


Catalog Number: (89155-144)
Supplier: Enzo Life Sciences
Description: Host: Mouse, Isotype: IgG2a lambda


Catalog Number: (89144-066)
Supplier: Enzo Life Sciences
Description: Active form of SUMO-2


Supplier: Enzo Life Sciences
Description: Cathepsin-L inhibitor

Supplier: Enzo Life Sciences
Description: Topoisomerase inhibitor

Catalog Number: (89166-008)
Supplier: Enzo Life Sciences
Description: Neuronal detection


Catalog Number: (89155-104)
Supplier: Enzo Life Sciences
Description: Host: Mouse, Isotype: IgG1


Supplier: Enzo Life Sciences
Description: Neprilysin inhibitor

Catalog Number: (89160-970)
Supplier: Enzo Life Sciences
Description: Fluorogenic substrate for several matrix metalloproteinases (MMPs). It is cleaved by MMP-1, MMP-3, MMP-7, MMP-8, MMP-9, MMP-11, MMP-12, MMP-13, and ADAM9/MDC9, but only slightly by MMP-2 and not at all by ADAM17/TACE. Ex/Em= 340nm/440nm, although 365/450 is also appropriate. Highly quenched, with strong fluorescence by Nma at 440nm once cleavage separates it from the aromatic Dnp moiety. Compatible with most fluorometers.


Catalog Number: (89158-360)
Supplier: Enzo Life Sciences
Description: Endogenous cannabinoid. Weak ligand of CB1 (Ki=23.8µM) and CB2 (Ki=13.9µM) receptor. Inhibits fatty acid amide hydrolase (FAAH) (IC50=5.1µM). Immunosuppressant, anti-inflammatory, anti-nociceptive and anti-convulsant in vivo. The exact mode of action has not yet been revealed. It has been suggested that PEA: i) binds to a yet to be discovered cannabinoid receptor similar to CB2; ii) administered in vivo elicits the synthesis of endogenous agonists of CB2; iii) acts as an "entourage" compound by enhancing the activity and/or by influencing the turnover of endogenous agonists of CB2, possibly but not uniquely, by inhibiting their degradation.


Catalog Number: (89163-058)
Supplier: Enzo Life Sciences
Description: Host: Rabbit


Catalog Number: (89164-436)
Supplier: Enzo Life Sciences
Description: Produced in insect cells. Full length active enzyme fused at the N-terminus to a GST-tag.


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