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Catalog Number: (CAAAJ60257-MC)
Supplier: Thermo Scientific Chemicals
Description: Nicotinyl acetylcholine receptor antagonist

Catalog Number: (CAAAJ64902-MC)
Supplier: Thermo Scientific Chemicals
Description: Labeling reagents with enhanced water solubility and amine reactivity as the activated NHS ester

Catalog Number: (CAAAH60014-MD)
Supplier: Thermo Scientific Chemicals

Catalog Number: (CAAAH60569-MD)
Supplier: Thermo Scientific Chemicals

Catalog Number: (TCS0944-100MG)
Supplier: TCI America
Description: Solifenacin Succinate, Purity: >98.0%(HPLC), Cas number: 242478-38-2, Molecular Formula: C23H26N2O2.C4H6O4, Molecular Weight: 480.56, Appearance: White - Almost white solid crystal powder, Size: 100MG

SDS


Supplier: Wards
Description: Individual iron masses with hexagonal bodies stamped with mass value, cone-shaped tops, and bottom bar and slot to hang additional weights.

Catalog Number: (CAAAJ62174-MD)
Supplier: Thermo Scientific Chemicals
Description: Crystalline powder

Catalog Number: (CA200062-754)
Supplier: Enzo Life Sciences
Description: The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.


Supplier: Thermo Scientific Chemicals
Description: Synthetic retinoid analog with specific affinity for the retinoid X receptor
Catalog Number: (CA200062-774)
Supplier: Enzo Life Sciences
Description: Grp94 (Glucose-regulated protein 94) is an abundant resident endoplasmic reticulum (ER) lumenal stress protein, which together with cytosolic Hsp90 belongs to the Hsp90 family of molecular chaperones. Grp94 expression is upregulated by stress conditions such as glucose starvation and heat shock, which promote protein misfolding or unfolding. In addition to a homeostatic role in protein folding and assembly, Grp94 can function in the intracellular trafficking of peptides from the extracellular space to the MHC class I antigen processing pathway of antigen presentation cells.


Catalog Number: (CA95045-172)
Supplier: Enzo Life Sciences
Description: The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

SDS


Catalog Number: (CAAAJ61410-MD)
Supplier: Thermo Scientific Chemicals
Description: A heterobifunctional coupling reagent useful for forming enzyme immunoconjugates

Catalog Number: (CAAAJ62528-MD)
Supplier: Thermo Scientific Chemicals
Description: Inhibits intracellular calcium mobilization

Catalog Number: (CAPI29810)
Supplier: Thermo Scientific
Description: Thermo Scientific Pierce Ethylene Glycol Solution provides exceptional antifreeze protection and storage stability for antibody-enzyme conjugates because it is purified to remove impurities commonly found traditional glycerol stocks.

Catalog Number: (CAAAJ60026-MC)
Supplier: Thermo Scientific Chemicals
Description: Peroxidase, Horseradish

Catalog Number: (CAAAJ61666-ME)
Supplier: Thermo Scientific Chemicals
Description: A vitamin A analog that inhibits cell proliferation and induces cell differentiation

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