You Searched For: trans-4-Fluoro-L-proline


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Catalog Number: (10371-898)
Supplier: Bioss
Description: Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferencially recognized via a LXXLAP motif.


Supplier: TCI America
Description: CAS Number: 14473-91-7
MDL Number: MFCD00004382
Molecular Formula: C9H7BrO2
Molecular Weight: 227.06
Purity/Analysis Method: >99.0% (GC,T)
Form: Crystal
Melting point (°C): 180

SDS

Catalog Number: (CAAAAL00441-06)
Supplier: Thermo Scientific Chemicals
Description: Fieser: 1,153

Supplier: Thermo Scientific Chemicals
Supplier: TCI America
Description: CAS Number: 3685-26-5
Molecular Formula: C7H12O3
Molecular Weight: 144.17
Purity/Analysis Method: >97.0% (GC,T)
Form: Crystal
Melting point (°C): 145
Supplier: TCI America
Description: CAS Number: 20595-47-5
MDL Number: MFCD03002786
Molecular Formula: C9H6Cl2O2
Molecular Weight: 217.05
Purity/Analysis Method: >96.0% (GC,T)
Form: Crystal
Melting point (°C): 192

SDS

Supplier: TCI America
Description: CAS Number: 134412-17-2
MDL Number: MFCD09839000
Molecular Formula: C23H28F2
Molecular Weight: 342.47
Purity/Analysis Method: >98.0% (GC)
Form: Crystal
Melting point (°C): 58

SDS

Supplier: TCI America
Description: CAS Number: 29275-88-5
MDL Number: MFCD00797465
Molecular Formula: C9H17NO2
Molecular Weight: 207.70
Purity/Analysis Method: >98.0% (GC,T)
Form: Crystal
Catalog Number: (TCA0877-025ML)
Supplier: TCI America
Description: CAS Number: 2497-18-9
MDL Number: MFCD00009474
Molecular Formula: C8H14O2
Molecular Weight: 142.20
Purity/Analysis Method: >97.0% (GC)
Form: Clear Liquid
Boiling point (°C): 165
Flash Point (°C): 64
Specific Gravity (20/20): 0.90

Supplier: TCI America
Description: CAS Number: 27687-14-5
Molecular Formula: C13H23NO4
Molecular Weight: 257.33
Purity/Analysis Method: >98.0% (GC,T)
Form: Crystal
Melting point (°C): 135

SDS

Supplier: TCI America
Description: CAS Number: 133261-33-3
Molecular Formula: C8H11F3O2
Molecular Weight: 196.17
Purity/Analysis Method: >98.0% (GC,T)
Form: Crystal
Color: White
Melting point (°C): 154
Supplier: Thermo Scientific Chemicals
Description: 4-tert-Butylcyclohexanecarboxylic acid (cis and trans mixture) predominantly trans ≥98%

Supplier: Thermo Scientific Chemicals
Description: MDL: MFCD00066429 Beilstein Registry No.: 3222748
Supplier: TCI America
Description: CAS Number: 201861-91-8
Molecular Formula: C14H10I2
Molecular Weight: 432.04
Purity/Analysis Method: >97.0% (GC)
Form: Crystal

SDS

Supplier: TCI America
Description: CAS Number: 2548-87-0
MDL Number: MFCD00007011
Molecular Formula: C8H14O
Molecular Weight: 126.20
Purity/Analysis Method: >96.0% (GC)
Form: Clear Liquid
Boiling point (°C): 78
Flash Point (°C): 65
Specific Gravity (20/20): 0.85
Supplier: TCI America
Description: 1-Butoxy-2,3-difluoro-4-(trans-4-propylcyclohexyl)benzene, Purity: >98.0%(GC), CAS number: 208709-55-1, Molecular Formula: C19H28F2O, Molecular Weight: 310.43, Form: Clear, Colorless - Almost colorless, Size: 5G

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