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Product Image-10830-258

Avantor Single-Use Tubing Assemblies, Avantor Fluid Handling

Catalog Number: (10830-258)
Supplier: VWR International
Description: Unique features make these tubing assemblies a superior alternative to others.
Product Image-MFLX40331-12

Masterflex® Single-Use Bag Port Disc Opposing Barb, Avantor®

Supplier: VWR International
Description: Designed for sample port and dip tube applications.

Product Image-76449-304

EZBio® Bioprocess, Single-Use, Double Bagged, Sterile Carboys, Foxx Life Sciences

Supplier: VWR International
Description: EZBio® single use carboys are available in amber HDPE, dark amber polypropylene, HDPE, polyethylene terephthalate glycol-modified (PETG), and polycarbonate (PC).

Image Unavailable-10490-338

Anti-INIP Rabbit Polyclonal Antibody

Catalog Number: (10490-338)
Supplier: Bioss
Description: The SOSS (Sensor of single-strand DNA) complex consists of multiple proteins that promote DNA repair and G2/M checkpoint downstream of the MRN (Mre11, Rad50 and Nbs1) complex. The complex is composed of SSBP1, INTS3 and C9orf80. Specifically, the SOSS complex binds to ssDNA at DNA lesions that influences diverse endpoints in the cellular DNA damage response. The complex is required for efficient homologous recombination-dependent repair of double-stranded breaks and ATM-dependent signaling pathways. C9orf80, also known as SOSS complex subunit C and Single-stranded DNA-binding protein-interacting protein 1 (SSBIP1), is a 104 amino acid nuclear protein that is a component of the SOSS complex. Upon DNA damage, C9orf80 along with other components of the SOSS complex migrate to the nucleus. There are two isoforms of C9orf80 that are produced as a result of alternative splicing events.
Image Unavailable-10495-514

Anti-INIP Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10495-514)
Supplier: Bioss
Description: The SOSS (Sensor of single-strand DNA) complex consists of multiple proteins that promote DNA repair and G2/M checkpoint downstream of the MRN (Mre11, Rad50 and Nbs1) complex. The complex is composed of SSBP1, INTS3 and C9orf80. Specifically, the SOSS complex binds to ssDNA at DNA lesions that influences diverse endpoints in the cellular DNA damage response. The complex is required for efficient homologous recombination-dependent repair of double-stranded breaks and ATM-dependent signaling pathways. C9orf80, also known as SOSS complex subunit C and Single-stranded DNA-binding protein-interacting protein 1 (SSBIP1), is a 104 amino acid nuclear protein that is a component of the SOSS complex. Upon DNA damage, C9orf80 along with other components of the SOSS complex migrate to the nucleus. There are two isoforms of C9orf80 that are produced as a result of alternative splicing events.
Product Image-82023-826

VWR® Gas Cylinder Wall Mounts and Supports

Supplier: VWR International
Description: Cylinder wall brackets secure 10.2 – 30.5 cm (4 – 12") diameter cylinders using 137.2L x 3.8Wcm (54 x 1<sup>1</sup>/<sub>2</sub>") polypropylene straps that can withstand up to 1200psi.

Product Image-89087-696

VWR® White Films for Luminescence and Microscopy

Catalog Number: (89087-696)
Supplier: VWR International
Description: These films are 240 µm thick white vinyl with adhesive, for use with white microplates.

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Product Image-MFLX07539-20

Masterflex® Single-Use Pump Head Systems, Avantor®

Catalog Number: (MFLX07539-20)
Supplier: VWR International
Description: Pulseless head mounts easily on Masterflex® L/S® drives.
Product Image-76470-786

VWR® SMS Sleeves, Made in USA

Catalog Number: (76470-786)
Supplier: VWR International
Description: VWR® Made in USA SMS Sleeves are an ideal option for single-use needs.
Product Image-CA89501-104

IntelliCAL™ ISEF121 Fluoride Ion Selective Electrode (ISE), Hach

Catalog Number: (CA89501-104)
Supplier: Hach
Description: IntelliCAL™ ISEF121 is a digital, combination fluoride ion selective electrode (ISE) with a non-refillable, single junction reference and built-in temperature sensor
Image Unavailable-76470-736

VWR® Disposable Short Sleeve Scrub Shirts

Supplier: VWR International
Description: VWR® Disposable short sleeve scrub shirts are an ideal option for single-use needs.

Product Image-36934-158

VWR® Traceable® Big-Digit See-Thru™ Thermometers

Supplier: VWR International
Description: Use outdoors and in storerooms, fume hoods, labs, cleanrooms, refrigerators, and plant areas.

Image Unavailable-MFLX75955-13

Masterflex® Single-Use Forceps, Avantor®

Supplier: VWR International
Description: No more cross-contamination.

Image Unavailable-MFLX40331-05

Masterflex® Single-Use Bag Port 1 Bottle Cap Thread", Avantor®

Catalog Number: (MFLX40331-05)
Supplier: VWR International
Description: Large opening makes it suitable for high viscosity liquid and powder applications.
Image Unavailable-10451-502

Anti-XPC Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog Number: (10451-502)
Supplier: Bioss
Description: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
Image Unavailable-10451-510

Anti-XPC Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10451-510)
Supplier: Bioss
Description: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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