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LabExact® Hydroblokr™ Serological Pipette Controller Protection Devices

Supplier: I.W. TREMONT CO., INC.
Description: LabExact® HydroBlokr™ is a novel filter technology which reduces serological pipette controller sample cross contamination and device failure with a check-valve effect when wet and blocks further passage of over aspirated aqueous solutions.

New Product

Product Image-89200-820

Accessories for VWR® Advanced Programmable Controller Refrigerated/Heated Circulating Baths

Supplier: VWR International

Image Unavailable-102979-196

ODN 2137 (Control for ODN 2006) endotoxin-free, sterile

Catalog Number: (102979-196)
Supplier: Adipogen
Description: Unmethylated CG dinucleotides within particular sequence contexts are responsible for the immunostimulatory activity of bacterial DNA. Synthetic oligonucleotides (ODN) that contain such CpG motifs (CpG ODNs) mimic microbial DNA. The innate immune system of vertebrates has the ability to recognize CpG motifs in microbial DNA via the Toll-like receptor (TLR) 9 if the CpG ODN were free of additional immune stimulatory contaminants often present in synthetic commercial CpG ODN preparations designed for molecular biology applications (i.e. PCR). Given that high quality CpG ODNs were used, a close link has been established between the expression of TLR9 on certain immune cell subsets and the modulation of the immune system by CpG DNA. Different types of CpG ODNs were identified based on their differing biological effects on different cell types: ODN Type A is a potent inducer of IFN-alpha in human PDC, (i.e. ODN 1585 or 2216) leading to antigen presenting cell (APC) maturation, whereas ODN Type B (i.e. ODN 2006 or ODN 1668 / ODN 1826) is a weak inducer of IFN-alpha but rather stimulates IL-8 production and increasing costimulatory and Ag-presenting molecules and triggers proliferation of B-cells and IgM and IL-6 production. A third type of CpG ODN has been identified, termed ODN Type C, with both high induction of INF-alpha in PDC and activation of B-cells. The sequence of CpG Type C (also called K) (i.e. ODN 2395 or M362) combines elements of both Type A and Type B and contains a central palindromic sequence with CG dinucleotides, a characteristic feature of Type A, and a TCGTCG motif at the 5' end, present in Type B CpG ODNs. Although the CpG motifs are thought to differ between mice and humans, in both species the recognition of CpG ODNs is mediated by TLR9. The optimal CpG motif in humans is GTCGTT and GACGTT for the murine sequence. However, recent evidence suggests that this sequence specificity is restricted to phosphorothioate (PS)-modified ODN and is not observed when a natural phosphodiester backbone is used. In recent years sequence requirements, specificity, signalling pathways and kinetics of the TLR9 suppression by inhibitory ODNs (iODNs) have been investigated.
Image Unavailable-102979-194

ODN 2243 (Control for ODN 2216) endotoxin-free, sterile

Catalog Number: (102979-194)
Supplier: Adipogen
Description: Unmethylated CG dinucleotides within particular sequence contexts are responsible for the immunostimulatory activity of bacterial DNA. Synthetic oligonucleotides (ODN) that contain such CpG motifs (CpG ODNs) mimic microbial DNA. The innate immune system of vertebrates has the ability to recognize CpG motifs in microbial DNA via the Toll-like receptor (TLR) 9 if the CpG ODN were free of additional immune stimulatory contaminants often present in synthetic commercial CpG ODN preparations designed for molecular biology applications (i.e. PCR). Given that high quality CpG ODNs were used, a close link has been established between the expression of TLR9 on certain immune cell subsets and the modulation of the immune system by CpG DNA. Different types of CpG ODNs were identified based on their differing biological effects on different cell types: ODN Type A is a potent inducer of IFN-alpha in human PDC, (i.e. ODN 1585 or 2216) leading to antigen presenting cell (APC) maturation, whereas ODN Type B (i.e. ODN 2006 or ODN 1668 / ODN 1826) is a weak inducer of IFN-alpha but rather stimulates IL-8 production and increasing costimulatory and Ag-presenting molecules and triggers proliferation of B-cells and IgM and IL-6 production. A third type of CpG ODN has been identified, termed ODN Type C, with both high induction of INF-alpha in PDC and activation of B-cells. The sequence of CpG Type C (also called K) (i.e. ODN 2395 or M362) combines elements of both Type A and Type B and contains a central palindromic sequence with CG dinucleotides, a characteristic feature of Type A, and a TCGTCG motif at the 5' end, present in Type B CpG ODNs. Although the CpG motifs are thought to differ between mice and humans, in both species the recognition of CpG ODNs is mediated by TLR9. The optimal CpG motif in humans is GTCGTT and GACGTT for the murine sequence. However, recent evidence suggests that this sequence specificity is restricted to phosphorothioate (PS)-modified ODN and is not observed when a natural phosphodiester backbone is used. In recent years sequence requirements, specificity, signalling pathways and kinetics of the TLR9 suppression by inhibitory ODNs (iODNs) have been investigated.
Product Image-75836-040

Histology Control Slides, Amyloid, Springside Scientific

Supplier: SPRINGSIDE SCIENTIFIC, LLC.
Description: 100% Human Tissue.

Product Image-75836-112

Histology Control Slides, Trichrome, Springside Scientific

Supplier: SPRINGSIDE SCIENTIFIC, LLC.
Description: 100% Human Tissue.

Product Image-75836-120

Histology Control Slides, Helico Bacteria, Springside Scientific

Supplier: SPRINGSIDE SCIENTIFIC, LLC.
Description: 100% Human Tissue.

Product Image-68310-050

EliminatR® Spill Control Sock, Contec®

Catalog Number: (68310-050)
Supplier: Contec
Description: The EliminatR® Sock is a disposable cleanroom sorbent sock designed for large spill containment as well as pickup. The sock is performance engineered utilizing 100% polyester knitted fabric, which has excellent sorbency for aqueous spills and is resistant to acids.

Certificates Small Business Enterprise


Product Image-76218-696

Accessories for OmegaZen™ Pipette Controller, Argos Technologies®

Supplier: Antyila Scientific

Irregular Voltage

Image Unavailable-77394-828

Eppendorf® Pipette Controllers and Multi-Dispensers - Trade-In

Supplier: Eppendorf
Description: Take advantage and trade in ANY brand pipette for a NEW Eppendorf Easypet 3, Pipet Helper, Repeater M4, Repeater E3 or E3x at a reduced price. Trust Eppendorf's premium products for quality in your laboratory, backed by 75 years of liquid handling experience and green, cutting-edge manufacturing.

Product Image-75836-116

Histology Control Slides, Acid Fast Bacteria, Springside Scientific

Supplier: SPRINGSIDE SCIENTIFIC, LLC.
Description: 100% Human Tissue.

Product Image-46000-772

PIG® HazMat Chemical Absorbent Sock, New Pig

Supplier: New Pig
Description: Absorbs and retains most acids, bases, and unknown liquids

Product Image-MFLX32928-76

AW-Lake Gear Flow Sensor Flow Monitor Transmitters

Catalog Number: (MFLX32928-76)
Supplier: AW-LAKE COMPANY
Description: Easily control flow of your gear flow sensors.
Product Image-CAAGG711660013

CrossLab Column Thermostat Accessories for HPLC, Agilent Technologies

Supplier: AGILENT TECHNOLOGIES, INC (CSD) CA
Description: Supplies to ensure the performance of the thermostatted column compartment in HPLC systems.

Image Unavailable-CA11027-980

Eppendorf® Easypet® 3 Electronic Pipette Controller

Catalog Number: (CA11027-980)
Supplier: Eppendorf
Description: Electronic pipetting doesn't come any more advanced than the Easypet 3 from Eppendorf. Designed to work with Eppendorf serological pipettes, you get complete speed control and utmost precision in an extremely light and well-balanced body that fits comfortably in your hand, for fatigue-free pipetting.

Environmentally Preferable


Product Image-75836-042

Histology Control Slides, Alician Blue, Springside Scientific

Supplier: SPRINGSIDE SCIENTIFIC, LLC.
Description: 100% Human Tissue.

Inquire for Price
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email CMD_NA@vwr.com or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:

  • issued document with your organization's Federal Tax ID Number
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  • Any other Government ID that includes the business name and address


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-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
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