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Supplier: Brandtech
Description: BRANDplates® inertGrade™ plates are sterile plates treated for the cultivation of non-adherent cell lines and suspension cultures

Catalog Number: (103007-252)
Supplier: Anaspec Inc
Description: This peptide is a C-terminal surface sorting signal with a conserved LPXTG motif, labeled with the Dabcyl/Edans FRET pair. Sortase cleaves surface proteins at the LPXTG motif and catalyzes the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Sortases are a family of Gram-positive transpeptidases responsible for anchoring surface protein virulence factors to the peptidoglycan cell wall layer. Surface proteins of Staphylococcus aureus are anchored to the bacterial cell wall by a mechanism requiring this C-terminal sorting signal. Cell wall sorting is the covalent attachment of surface proteins to the peptidoglycan via a C-terminal sorting signal that contains a consensus LPXTG sequence. Cleavage of this FRET substrate by sortase reveals the fluorescent signal that may be measured to study sortase activity. Inhibition of the sortase activity is a potential way of treatment of the staphylococcal infection. The LPXTG motif is conserved in more than 100 surface proteins of Gram-positive pathogens.
Sequence:Dabcyl-QALPETGEE-Edans
MW:1472.6 Da
% peak area by HPLC:95
Storage condition:-20° C


Supplier: Corning
Description: Poly-D-Lysine (PDL) and Poly-L-Lysine (PLL) are synthetic compounds that enhance cell adhesion and protein absorption by altering surface charges on the culture substrate. In addition to promoting cell adhesion, poly-lysine surface treatments support neurite outgrowth and improve the survival of many central nervous system (CNS) primary cells in culture. As PDL and PLL are synthetic molecules, they do not stimulate biological activity in the cells cultured on them, and they do not introduce impurities carried by natural polymers.
Catalog Number: (CACB354086)
Supplier: Corning
Description: Poly-D-Lysine (PDL) and Poly-L-Lysine (PLL) are synthetic compounds that enhance cell adhesion and protein absorption by altering surface charges on the culture substrate. In addition to promoting cell adhesion, poly-lysine surface treatments support neurite outgrowth and improve the survival of many central nervous system (CNS) primary cells in culture. As PDL and PLL are synthetic molecules, they do not stimulate biological activity in the cells cultured on them, and they do not introduce impurities carried by natural polymers.

Supplier: MicroSolv Technology Corp
Description: Reduced surface activity, non treated clear and amber glass vials. Convenient kits are packaged with high purity caps for low adsorbance.

Catalog Number: (89360-968)
Supplier: Genetex
Description: Cancer antigen 125 (CA125) is a protein found on the surface of many ovarian cancer cells. It also can be found in other cancers and in small amounts within normal tissue. CA125 is used as a tumor marker an indicator of some types of cancer, especially ovarian cancer. Studies are being done to determine whether CA125 can be used as a screening test for ovarian cancer. Most often, the CA125 test is used to help determine the effectiveness of treatment for ovarian cancer or to help diagnose the recurrence of ovarian cancer.


Catalog Number: (77007-620)
Supplier: Genscript
Description: Omalizumab with trade name Xolair, is an FDA-approved drug for the treatment of moderate to severe persistent asthma in adults and adolescents (12 years of age and above). It is a recombinant humanized monoclonal antibody. It selectively binds to human immunoglobulin E (IgE). Omalizumab inhibits the binding of IgE to the high-affinity IgE receptor (FcεRI) on the surface of mast cells and basophils. Anti-Omalizumab Antibody (10G3), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Omalizumab.


Supplier: Corning
Description: Poly-D-Lysine (PDL) and Poly-L-Lysine (PLL) are synthetic compounds that enhance cell adhesion and protein absorption by altering surface charges on the culture substrate. In addition to promoting cell adhesion, poly-lysine surface treatments support neurite outgrowth and improve the survival of many central nervous system (CNS) primary cells in culture. As PDL and PLL are synthetic molecules, they do not stimulate biological activity in the cells cultured on them, and they do not introduce impurities carried by natural polymers.
Supplier: Azer Scientific Inc.
Description: Azer Scientific’s ExacTip™ pipette tip line is the ideal choice for a universal pipette tip or universal filtered pipette tip. The surface and material of the filter tips utilize special processes and polypropylene resins to ensure the low retention qualities for ensuring they are one of the most accurate pipette tips in the market.
Catalog Number: (10797-156)
Supplier: Prosci
Description: T-cell surface glycoprotein CD4 is also known as T-cell surface antigen T4/Leu-3. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is accessory protein for MHC class-II antigen/T-cell receptor interaction. CD4 induces the aggregation of lipid rafts. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors. Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.


Catalog Number: (10797-786)
Supplier: Prosci
Description: Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-?. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-? by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-? secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.


Catalog Number: (77436-908)
Supplier: Bioss
Description: Angiotensin II (Ang II) is an important physiological effector of blood pressure and volume regulation through vasoconstriction, aldosterone release, sodium uptake and thirst stimulation. Although Ang II interacts with two types of cell surface receptors, AT1 and AT2, most of the major cardiovascular effects seem to be mediated through AT1. Molecular cloning of the AT1 protein has shown it to be a member of the G protein-associated seven transmembrane protein receptor family. Ang II treatment of cells results in activation of several signal transduction pathways as evidenced by tyrosine phosphorylation of several proteins and induction of others. PLC?is phosphorylated after 30 seconds of treatment with Angiotensin II, indicating this as an early signal transduction event. Ang II treatment also stimulates phosphorylation of Shc, FAK and MAP kinases, and induces MKP-1, indicating stimulation of growth factor pathways. Ang II stimulation through AT1 has been shown to activate the JAK/Stat pathway involving a direct interaction between JAK2 and AT1 as demonstrated by coimmunoprecipitation. The AT1 receptor has no cytoplasmic kinase domain, but is able to function as a substrate for Src kinases and has several putative phosphorylation sites.


Catalog Number: (77007-520)
Supplier: Genscript
Description: Omalizumab with trade name Xolair, is an FDA-approved drug for the treatment of moderate to severe persistent asthma in adults and adolescents (12 years of age and above). It is a recombinant humanized monoclonal antibody. It selectively binds to human immunoglobulin E (IgE). Omalizumab inhibits the binding of IgE to the high-affinity IgE receptor (FcεRI) on the surface of mast cells and basophils. Anti-Omalizumab Antibody (7G11), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with omalizumab.


Supplier: Diagnostic Biosystems
Description: The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer types express PD-L1 and evade immune recognition via the PD-1/PD-L1 interaction. Precision therapies targeting the PD-1/PD-L1 pathway have the potential to improve response and thereby offer a novel treatment avenue to some patients with cancer.

Catalog Number: (76121-230)
Supplier: Bioss
Description: Hepatitis B e-antigen (HBeAg) is a viral protein associated with HBV infections. Unlike the surface antigen, the e-antigen is found in the blood only when there are viruses also present. When the virus goes into hiding,? the e-antigen will no longer be present in the blood. HBeAg is often used as a marker of ability to spread the virus to other people (infectivity). Measurement of e-antigen may also be used to monitor the effectiveness of HBV treatment; successful treatment will usually eliminate HBeAg from the blood and lead to development of against e-antigen (anti-HBe). There are some types (strains) of HBV that do not make e-antigen; these are especially common in the Middle East and Asia. In areas where these strains of HBV are common, testing for HBeAg is not very useful.

Catalog Number: (76121-232)
Supplier: Bioss
Description: Hepatitis B e-antigen (HBeAg) is a viral protein associated with HBV infections. Unlike the surface antigen, the e-antigen is found in the blood only when there are viruses also present. When the virus goes into hiding,? the e-antigen will no longer be present in the blood. HBeAg is often used as a marker of ability to spread the virus to other people (infectivity). Measurement of e-antigen may also be used to monitor the effectiveness of HBV treatment; successful treatment will usually eliminate HBeAg from the blood and lead to development of against e-antigen (anti-HBe). There are some types (strains) of HBV that do not make e-antigen; these are especially common in the Middle East and Asia. In areas where these strains of HBV are common, testing for HBeAg is not very useful.


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