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Image Unavailable-10402-724

Anti-BUB1 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10402-724)
Supplier: Bioss
Description: Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGOL1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.
Product Image-CAAGG366667045

CrossLab ORS (Octopole Reaction System) Supplies for ICP-MS, Agilent Technologies

Supplier: AGILENT TECHNOLOGIES, INC (CSD) CA
Description: ICP-MS Octopole Reaction System (ORS) cell components for Agilent 7700, 7800, 7900, 8800, 8900.

Product Image-10400-064

Anti-BUB1 Rabbit Polyclonal Antibody

Catalog Number: (10400-064)
Supplier: Bioss
Description: Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGOL1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.
Product Image-KT953855-1047

KIMBLE® ULTRA-WARE® 47 mm Microfiltration Assembly with Stainless Steel Support, DWK Life Sciences

Catalog Number: (KT953855-1047)
Supplier: DWK Life Sciences (KIMBLE)
Description: This 47 mm vacuum microfiltration assembly is designed to handle up to 500 ml of sample liquids for the analysis of particulate or microbiological contamination. It has a stainless steel support and is used for filtering viscous or proteinaceous solutions or to produce ultra-clean filtrate.
Product Image-CAAG210164100

CrossLab Burners and Supplies for Agilent Instruments, Agilent Technologies

Supplier: AGILENT TECHNOLOGIES, INC (CSD) CA
Description: Mark 7 burner used with Mark 7 flame atomization system for current Agilent flame AA instruments.

Product Image-76533-516

Sentinel XL® CBRN Butyl Hood Assembly, ILC Dover

Catalog Number: (76533-516)
Supplier: ILC DOVER LP
Description: The only CBRN loose-fitting powered air purifying respirator (PAPR) hood designed to deliver a CAP 2 protection rating when used with the Sentinel XL® blower.
Product Image-CAG1958-67098

CrossLab LC/MSD Supplies for HPLC, Agilent Technologies

Supplier: AGILENT TECHNOLOGIES, INC (CSD) CA
Description: A range of high-quality supplies for LC/MSD to ensure continued high levels of system performance.

Product Image-89084-708

Labjaws Lab Frame Set, Extra Large, Ace Glass

Catalog Number: (89084-708)
Supplier: Ace Glass
Description: This wall-type Lab Frame Set can be built into assemblies as large as 1.2 x 1.8 meters

Small Business Enterprise Product available on GSA Advantage®


Product Image-76018-418

EZBio® Single-Use Media Bottle, PETG, Closed Cap, Sterile

Supplier: Foxx Life Sciences
Description: EZBio® single-use PETG bottle assemblies are an innovative and cost efficient option for single-use applications.

Product Image-76018-438

EZBio® Vent Filter, 0.22 µm, Nonsterile, Foxx Life Sciences

Supplier: Foxx Life Sciences
Description: EZBio® PTFE vent filters are used with EZBio® Single-Use bottle assemblies, which are perfect for fluid transfer and storage.

Product Image-77581-222

SteriPlast® Detectable Spatulas

Catalog Number: (77581-222)
Supplier: BURKLE INC
Description: These detectable SteriPlast® spatulas, made of blue PS, are produced and assembled in a class seven cleanroom (10,000), individually packaged for disposable use and then sterilized by gamma rays. Ideal for sampling powders, granulates and pastes.

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Image Unavailable-75789-212

Human Recombinant p27 (from E. coli)

Catalog Number: (75789-212)
Supplier: Prosci
Description: Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an activator of Cyclin Type D-CDK4 complexes depending on its phosphorylation state and stoichometry.
Product Image-77392-728

Nanodisc MSP1D1 dH5 DMPC

Catalog Number: (77392-728)
Supplier: CUBE BIOTECH
Description: This product is a pre-assembled nanodisc. Its intended purpose is to stabilize a cell-free expressed membrane protein.
Product Image-77392-804

Nanodisc Mouse MSP1E3D1-His DMPG

Catalog Number: (77392-804)
Supplier: CUBE BIOTECH
Description: This product is a pre-assembled nanodisc. Its intended purpose is to stabilize a cell-free expressed membrane protein.
Product Image-77392-724

Nanodisc MSP1D1 POPC

Catalog Number: (77392-724)
Supplier: CUBE BIOTECH
Description: This product is a pre-assembled nanodisc. Its intended purpose is to stabilize a cell-free expressed membrane protein.
Image Unavailable-10431-222

Anti-RBBP4 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10431-222)
Supplier: Bioss
Description: RbAp48 (Retinoblastoma-binding protein p48 or Rb-associated protein p48)is a WD repeat protein that is a core histone binding subunit common to several complexes involved in chromatin assembly, chromatin remodeling, and histone deacetylation. These complexes include Chromatin Assembly Factor 1 (CAF1), which is required for chromatin assembly following DNA replication and repair, the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and subsequent transcriptional repression, the nucleosome remodeling and histone deacetylation complex NuRD, the nucleosome remodeling factor (NURF) complex, and the PRC2 complex, which promotes repression of homeotic genes during development. RpAp48 also interacts with the retinoblastoma protein, and with SPEN/MINT and BRCA1. It is also a component of the DREAM complex, which represses cell cycle-dependent genes in quiescent cells.
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