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Image Unavailable-10349-234

Anti-HPV33 E6 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10349-234)
Supplier: Bioss
Description: Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro. Human papillomaviruses (HPV) are small DNA viruses which infect epithelia of the skin and mucosa. Over 90 types have been identified and they mostly cause a variety of benign lesions such as warts and verrucae. However, some subtypes, notably types 16 and 18, 31 and 33, have been confirmed as agents which cause cervical cancer. The E6 protein is a transcriptional transactivator. Binds double-stranded DNA. This protein may be involved in the oncogenic potential of this virus (cervical neoplasia-associated virus).
Image Unavailable-10430-498

Anti-RSRC2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10430-498)
Supplier: Bioss
Description: RSRC2 (arginine/serine-rich coiled-coil 2) possibly plays a role in cell proliferation and may be a novel tumor suppressor of esophageal cancer cell growth.
Image Unavailable-CA90001-742

Diagnostic Tests—Adjuvant Complete to Neisseria meningitidis Antiserum, BD Diagnostics

Supplier: BD
Description: Antigens and antisera used for slide agglutination tests and immunofluorescence. BD Difco Listeria O Antigens Types 1 and 4 (Slide) are suspensions of appropriate<i> </i>serotypes containing 0.3% formaldehyde as a preservative

SDS Certificates

Product Image-10097-908

Anti-IGFBP7 Rabbit Polyclonal Antibody (Biotin)

Catalog Number: (10097-908)
Supplier: Prosci
Description: IGF-BPs form high affinity complexes with both IGF-I and IGF-II and act to control of the distribution, function and activity of IGFs in various cell tissues and body fluids. There are seven named IGF-BPs. IGF-BP7 plays a role in skeletal myogenesis by binding to IGF in a manner that inhibits IGF induced differentiation of skeletal myoblasts, without affecting IGF induced proliferation. Additionally, IGF-BP7 suppresses growth and colony formation of prostate and breast cancer cell lines through an IGF independent mechanism, which causes a delay in the G1 phase of the cell cycle, and increased apoptosis. IGF-BP7 is expressed in a wide range of normal human tissues and it usually shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin.
Product Image-10092-598

Anti-POPDC3 Rabbit Polyclonal Antibody

Catalog Number: (10092-598)
Supplier: Proteintech
Description: The Popeye domain-containing (POPDC) gene family includes BVES/POPDC1, POPDC2 and POPDC3. POPDC proteins are highly evolutionarily conserved transmembrane proteins expressed in embryonic epithelium, heart and muscle. POPDC3 is a 291-amino acid protein containing three putative transmembrane domains. It has been reported that POPDC3 expression is reduced in gastric cancer, suggesting it might play an important role in the progression and metastases of gastric cancer.
Image Unavailable-CAAA35589-K2

Potassium dichromate standardised solution 0.025 N in aqueous solution

Catalog Number: (CAAA35589-K2)
Supplier: Thermo Scientific Chemicals
Description: 0.025N Standardized Solution.Liquid,DANGER: Cancer risk, irritates skin, eyes & mucous membranes,500ml,1L.

Certificates


Image Unavailable-10434-482

Anti-HPN Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10434-482)
Supplier: Bioss
Description: This gene encodes a type II transmembrane serine protease. The encoded protein has an extracellular region that consists of two domains, a catalytic serine protease domain and a non-catalytic scavenger receptor cysteine-rich domain. This protein may be involved in diverse cellular functions including blood coagulation, maintenance of cell morphology and the growth and progression of certain cancers, particularly prostate cancer. Alternative splicing results in multiple transcript variants.
Product Image-10090-182

Anti-MGAT4C Rabbit Polyclonal Antibody

Catalog Number: (10090-182)
Supplier: Proteintech
Description: MGAT4C is predicted to be a glycosyltransferase that catalyzes a GlcNAc β1-4 linkage to the core mannose residues of N-glycans, resulting in N-glycans with tri- or tetraantennary structures.Recently MGAT4C has been found to get involved in processing complex N-glycan structures on CD133 and CD133 has been identified as a substrate of MGAT4C. Given to the fact that CD133 is widely used as a marker of numerous stem cell and cancer stem cell types, MGAT4C may have an important role in certain cancers.(21937449)
Product Image-10085-604

Anti-DYX1C1 Rabbit Polyclonal Antibody

Catalog Number: (10085-604)
Supplier: Proteintech
Description: DYX1C1 initially was described as the first candidate gene for developmental dyslexia. The protein contains three TPR motifs and one p23 domain, all commonly known for their protein-protein interactions. It also has been linked to neuronal migration. Recently it has been reported that the expression of DYX1C1 protein is lost in breast cancer and patients who have lost DYX1C1 expression have a poor overall survival,indicating that DYX1C1 is a potential prognostic biomarker in breast cancer.
Product Image-89416-344

Anti-STEAP1 Rabbit Polyclonal Antibody

Catalog Number: (89416-344)
Supplier: Prosci
Description: STEAP1 Antibody: The six-transmembrane epithelial antigen of prostate 1 (STEAP1) was the first member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. The normal function of STEAP is still uncertain; unlike other members of the STEAP family, STEAP1 does not promote iron or copper reduction or uptake and lacks the FNO-like reductase domain critical for activity. However, its expression is highly increased in multiple cancer cell lines, including prostate, bladder, colon, and ovarian cancers. Supporting this is evidence that STEAP1 peptides can be used to stimulate CD8+ T cells from healthy donors, enabling them to recognize STEAP1-positive human tumor cells, suggesting that STEAP1 may a potential target for cancer immunotherapy. At least three isoforms of STEAP1 are known to exist.
Image Unavailable-10426-968

Anti-PBOV1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10426-968)
Supplier: Bioss
Description: This gene is overexpressed in prostate and breast cancer.
Image Unavailable-75789-342

Human Recombinant Kallikrein 13 (from Cells)

Catalog Number: (75789-342)
Supplier: Prosci
Description: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.
Image Unavailable-75789-338

Human Recombinant Kallikrein 10 (from Cells)

Catalog Number: (75789-338)
Supplier: Prosci
Description: Kallikreins are a subgroup of Serine Proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.
Image Unavailable-75789-352

Human Recombinant Kallikrein 8 (from Cells)

Catalog Number: (75789-352)
Supplier: Prosci
Description: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.
Image Unavailable-75789-344

Human Recombinant Kallikrein 4 (from Cells)

Catalog Number: (75789-344)
Supplier: Prosci
Description: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen members of the Kallikrein subfamily located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.
Product Image-77590-192

Crystal Digital PCR® Assay for BRCA1 Methylation

Supplier: STILLA TECHNOLOGIES, INC.
Description: Assay-specific Crystal Flex Probes and primers for the detection of BRCA1 Methylation and its Positive Control. The BRCA1 Methylation Crystal Digital PCR® Assay is a 10X assay designed to detect and quantify methylation of the BRCA1 promoter using the Ruby Chip. BRCA1 is crucial for maintaining genomic stability by repairing DNA damage, regulating the cell cycle, and acting as a tumor suppressor to prevent cancer.

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