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Anti-TP53 Mouse Monoclonal Antibody (CF405S) [clone: BP53-12 DO-7]

Supplier: Biotium
Description: This antibody recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. Its epitope maps within the N-terminus (aa 20-25) of p53 oncoprotein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Image-470201-490

Tergazyme® Enzyme-Active Powdered Detergent

Catalog Number: (470201-490)
Supplier: Alconox
Description: Tergazyme is a concentrated, anionic detergent with protease enzyme for manual and ultrasonic cleaning. Excellent for removal of proteinaceous soils, tissue, blood and body fluids from glassware, metals, plastic, ceramic, porcelain, rubber and fiberglass with no interfering residues. Ideal as a cleaning agent in hospital instruments, dairy equipment, laboratory ware, reverse osmosis and ultrafiltration membranes and units, sampling apparatus, pharmaceutical apparatus, cosmetics manufacturing equipment, tubing, pipes, optical parts, process equipment, industrial parts, desalination plants, tanks and reactors.

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Image Unavailable-10333-080

Anti-MAPT Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10333-080)
Supplier: Bioss
Description: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Product Image-10070-326

Anti-MAPT Rabbit Polyclonal Antibody

Catalog Number: (10070-326)
Supplier: Prosci
Description: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Product Image-10070-334

Anti-MAPT Rabbit Polyclonal Antibody

Catalog Number: (10070-334)
Supplier: Prosci
Description: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Product Image-10070-240

Anti-MAPT Rabbit Polyclonal Antibody

Catalog Number: (10070-240)
Supplier: Prosci
Description: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Product Image-CA100-401-A05

Anti-CUL5 Rabbit Monoclonal Antibody [clone: 14C5]

Catalog Number: (CA100-401-A05)
Supplier: Rockland Immunochemical
Description: This antibody reacts with human Cul5 by western blot and immunoprecipitation.  The antibody immunoprecipitates Protein from cell lysates (using 293T, U2OS and others).  This antibody also co-immunoprecipitates associated Proteins.
Product Image-10813-714

Anti-MAPT Rabbit Polyclonal Antibody

Catalog Number: (10813-714)
Supplier: Prosci
Description: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Image Unavailable-75967-656

Anti-TP53 Mouse Monoclonal Antibody (CF488A) [clone: TRP/816]

Supplier: Biotium
Description: This antibody recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Product Image-76337-244

BRAND® Inserts 2 in 1 for Cell Culture, BrandTech® Scientific, Inc.

Supplier: Brandtech
Description: BRAND® insert 2 in 1 offers unlimited flexibility for 2D and 3D cell culture. Inserts can be used as a free standing or hanging insert for co-culture, air-lift cultures, migration assays and more.

Image Unavailable-89266-640

Anti-LOC51057 Rabbit Polyclonal Antibody

Catalog Number: (89266-640)
Supplier: Genetex
Description: Rabbit polyclonal antibody to LOC51057 (N-terminal)
Image Unavailable-10794-958

Anti-IL10 Rat Monoclonal Antibody [clone: 9D7]

Catalog Number: (10794-958)
Supplier: Genetex
Description: Rat monoclonal antibody [9D7] to IL10
Image Unavailable-77565-074

Human Recombinant SAE1/UBA2 Complex (GST tag), Active (from Baculovirus-Insect Cells)

Supplier: Sino Biological
Description: Recombinant full length human SAE1 (UBLE1A) and human UBA2 (SAE2) were co-expressed by baculovirus in Sf9 insect cells using an N-terminal His tag on SAE1 and GST tag on UBA2.

New Product

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Human Recombinant Tau-441, PKA-phosphorylated (from E. coli)

Supplier: Sino Biological
Description: Recombinant human tag-free Tau-441 was co-expressed with PKAc alpha in <i>E. coli</i> cells. The Tau-441 protein was phosphorylated by PKAc alpha <i>in vivo </i>and<i> in vitro</i> prior to the final chromatography purification.

New Product

Image Unavailable-10369-770

Anti-MAPT Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10369-770)
Supplier: Bioss
Description: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Image Unavailable-76084-760

Anti-P53 Ser20 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76084-760)
Supplier: Bioss
Description: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email CMD_NA@vwr.com or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:

  • issued document with your organization's Federal Tax ID Number
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  • Any other Government ID that includes the business name and address


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