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Anti-TP53 Mouse Monoclonal Antibody (Biotin) [clone: DO-7]

Supplier: Biotium
Description: This antibody recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. Its epitope maps within the N-terminus (aa 37-45) of p53. Monoclonal antibody PAb1801 does not block the binding of DO-7 MAb to p53 in an ELISA test. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

Image Unavailable-75969-118

Anti-TP53 Mouse Monoclonal Antibody [clone: DO-7]

Supplier: Biotium
Description: This antibody recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. Its epitope maps within the N-terminus (aa 37-45) of p53. Monoclonal antibody PAb1801 does not block the binding of DO-7 MAb to p53 in an ELISA test. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

Image Unavailable-77564-434

Human Recombinant Tau-441, CAMK2-phosphorylated (from E. coli)

Supplier: Sino Biological
Description: Recombinant human tag-free Tau-441 was co-expressed with CAMK2 in <i>E. coli</i> cells. The Tau-441 protein was phosphorylated by CAMK2<i> in vivo</i> and <i>in vitro</i> prior to the final chromatography purification.

New Product

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Human Recombinant Tau-441, PHKG2-phosphorylated (from E. coli)

Supplier: Sino Biological
Description: Recombinant human tag-free Tau-441 was co-expressed with PHKG2 in<i> E. coli </i>cells. The Tau-441 protein was phosphorylated by PHKG2<i> in vivo</i> and<i> in vitro</i> prior to the final chromatography purification.

New Product

Image Unavailable-75967-570

Anti-TP53 Mouse Monoclonal Antibody [clone: BP53-12 DO-7]

Supplier: Biotium
Description: This antibody recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. Its epitope maps within the N-terminus (aa 20-25) of p53 oncoprotein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

Image Unavailable-76477-178

Hypersil GOLD™ PFP HPLC Column

Catalog Number: (76477-178)
Supplier: Thermo Scientific
Description: Analyze difficult-to-solve mixtures of halogenated compounds and non-halogenated polar compounds with Thermo Scientific™ Hypersil GOLD™ PFP (pentafluorophenyl) HPLC columns.
Image Unavailable-77564-442

Human Recombinant Tau-441, GSK3beta-phosphorylated (from E. coli)

Supplier: Sino Biological
Description: Recombinant human tag-free Tau-441 was co-expressed with GSK3beta in <i>E. coli</i> cells. The Tau-441 protein was phosphorylated by GSK3beta<i> in vivo</i> and <i>in vitro</i> prior to the final chromatography purification.

New Product

Image Unavailable-77561-472

Human Recombinant PI3K (p110 beta/p85 alpha, His tag), Active (from Baculovirus-Insect Cells)

Supplier: Sino Biological
Description: Recombinant full length human p110 beta and human p85 alpha were co-expressed by baculovirus in Sf9 insect cells using an N-terminal His tag on both proteins.

New Product

Product Image-10058-580

Drilled Uniliner® Inlet Liner with Hole near Bottom and Top Taper for Agilent GCs Equipped with Split/Splitless Inlets, Restek

Catalog Number: (10058-580)
Supplier: Restek
Description: Use of these liners helps ensure an inert GC flow path for higher sensitivity, accuracy, and reproducibility.
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Human Recombinant PI3K (p110 beta/p85 beta, His tag), Active (from Baculovirus-Insect Cells)

Supplier: Sino Biological
Description: Recombinant full length human p110 beta and human p85 beta were co-expressed by baculovirus in Sf9 insect cells using an N-terminal His tag on both proteins.

New Product

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Anti-TP53 Mouse Monoclonal Antibody (CF568) [clone: TRP/817]

Supplier: Biotium
Description: This antibody recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 protein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

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Anti-TP53 Mouse Monoclonal Antibody (CF405S) [clone: DO-7]

Supplier: Biotium
Description: This antibody recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. Its epitope maps within the N-terminus (aa 37-45) of p53. Monoclonal antibody PAb1801 does not block the binding of DO-7 MAb to p53 in an ELISA test. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Image-10041-464

Hypersil GOLD™ PFP HPLC Columns, Thermo Scientific

Supplier: Thermo Scientific
Description: Analyze difficult-to-resolve mixtures of halogenated compounds and non-halogenated polar compounds with Thermo Scientific™ Hypersil GOLD™ PFP (pentafluorophenyl) HPLC columns.

Product Image-10851-524

MXT®-1701 Columns (Siltek®-treated stainless steel), Restek

Supplier: Restek
Description: MXT®-1701 columns are good for general-purpose applications involving alcohols, oxygenates, PCB congeners, and pesticides.

Image Unavailable-H-6935.0005BA

(D-Arg¹,D-Phe⁵,D-Trp⁷·⁹,Leu¹¹)-Substance P

Supplier: Bachem Americas
Description: Small synthetic molecules called growth-hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary through a G protein-coupled receptor (GHS-R). Recently, ghrelin ("ghre" is the Proto-Indo-European root of the word "grow") has been identified as an endogenous ligand for GHS-R. These peptides consist of 28 amino acids with an octanoyl-residue at Ser³, which is essential for expressing activity. Ghrelin stimulates GH release from rat primary culture pituitary cells in a dose-dependent manner and induces an increase in intracellular Ca²⁺ in GHS-R-expressing cells with an EC₅₀ value of 2.5 nM. Human ghrelin is homologous to rat ghrelin apart from two amino acids. The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelin. In future, ghrelin might be used in the treatment of aging patients as well as in patients with idiopathic GH deficiency, obesity, osteoporosis or cardiovascular diseases.

Product Image-10500-172

GsBP®-Tubing PEG Deactivated GC Column, GS-Tek

Supplier: General Separation Technologies, Inc.
Description: GC tubing.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email CMD_NA@vwr.com or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:

  • issued document with your organization's Federal Tax ID Number
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